Chapter 220: Blood Transfusion Between Relatives
The problem on Dean Wu's side has been solved for the time being. But in the past three days, the most important and crucial event has not gone too smoothly - Hou Huiying's liver is rapidly failing. Her husband, Tang Xingde, and son, Tang Wen, are in stable condition. Tang Wen has even no breathing symptoms, and he seems to be in good spirits at present. He could even get out of the hospital bed and walk to his mother's bedside and look at her with a worried expression.
Hou Huiying's condition is not good, very bad. Although Wu Youqian made a quick decision, although Director Xiong successfully completed the extremely difficult percutaneous percutaneous thrift of the hepatic portal vein and gastric fundus vein embolization to stop bleeding. But the arrival of DIC still dealt a great blow to Hou Huiying's already weak body. Speaking of which, thanks to the independent departments of hematology and transfusion medicine in the four hospitals, it is possible to stabilize her vital signs for the time being.
In a tertiary hospital without these specialized departments and strengths, it is not a joke that the mortality rate of DIC exceeds 50%. In fact, the four hospitals have been able to respond to the occurrence of DIC in patients many times in a row, and have also been able to stabilize their vital signs, in fact, thanks to these specialized departments that have only recently begun to be gradually subdivided. They are able to respond accurately to severe fluctuations in the patient's vital signs, and accurately adjust anticoagulant drugs such as low-molecular-weight heparin to save the patient's life with the fewest side effects.
But even with the full assistance of the two departments, Hou Huiying only picked up a life - she is still far, far away from being completely safe.
The biggest trouble is the damage to her liver.
Yersinia pestis can damage every organ in the body, and the liver, as the largest detoxification organ in the human body, is undoubtedly one of the most damaged organs in this storm. Whether it was damaged and dead cells, or toxic substances secreted by bacteria, or even the various drugs used in large quantities by the four hospitals to treat her illness. Many factors are harming Hou Huiying's liver.
And what really broke her liver down was the numerous microthrombis caused by DIC.
A large number of micro-thrombs appeared in Hou's liver and lungs, and also caused multiple subcutaneous hemorrhages on Hou's body skin. Large purple subcutaneous bleeding marks look chilling.
After several consultations between the departments of hematology and transfusion medicine, the departments of hematology and transfusion medicine decided to send doctors to the clean room of the emergency room for treatment. Hou Huiying was given low-molecular-weight heparin, hemostatic sensitivity and fibrinogen supplementation. After two days of treatment, Hou Huiying's blood clotting function and blood in the urine improved slightly, but her liver function still showed no signs of improvement - her total bilirubin had been hovering around 400.
"Starting today, I'm going to give your mother artificial liver treatment. Sun Lien was wearing a P4 protective suit, and Tang Wendao, who was standing on the side, said, "How are you feeling today?"
Tang Wen was silent for a while and then sighed, "I'm still alive, that's enough." He looked worriedly at his unconscious mother and the bruises on her arms, "Will the artificial liver be useful?"
"As long as the machine is functioning, it will be useful. Sun Lien tried to cheer up this "big boy" who was about the same age as himself, "The artificial liver will replace your mother's liver to a certain extent, so that the situation in her body will gradually return to a relatively normal level......
"And then?" Tang Wen sat down on the side of his mother's bed and sighed, "According to you, her liver damage has reached the point where there is no way to recover on her own, right?
Sun Lien put down the work in his hand and gently patted Tang Wen's shoulder, "I fully understand how much pressure you have right now, but I must ask you to be strong." He pointed to the two beds next to him, "Your parents are not completely out of danger yet, and both of them are currently in a coma. There are a lot of decisions that you need to make for them โ I know you're running out of it, but all I can say is that you have to keep going. โ
"You're really bad at comforting people. Tang Wen pretended to rub his stomach, "I started to have a stomachache when you said a series of words. โ
Although he still spoke in a nasal voice, at least he seemed to be in good spirits.
"The level of your jokes is not too high. Sun Lien came over and pressed Tang Wen's stomach, pretending to be examined, "Don't lie to the doctor about your symptoms! Do you want to undergo hundreds of more tests?"
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"Dr. Sun, I have something I want to ask you. The doctors who specialize in intensive care medicine in the expert group and the intensive care doctors from the four hospitals worked together to attach the artificial liver to Hou Huiying's body. On the side, Sun Lien was marking Hou Huiying's current vital signs in the record book. After Sun Lien put down the pen, Tang Wen suddenly stopped Sun Lien, "My mother's current condition, if the condition of the liver does not improve, should I consider liver transplantation?"
Sun Lien nodded, "This is the worst-case scenario, but liver transplantation is indeed the last and most effective means." โ
"I just looked it up. Tang Wen showed Sun Lien the mobile phone in his hand, "Relatives can donate livers." โ
Sun Lien had already guessed what Tang Wen meant, and he shook his head at Tang Wen, "It's a pity that you can't." โ
"Why?" Tang Wen was anxious, "Why can't I?"
"Why did you forget why you were sent to the hospital?" Sun Lien pointed to the protective clothing on his body, "Plague, you are infected with plague." Infected patients should never donate organs. โ
People who are infected are absolutely not allowed to receive or donate organs. The reason for this is also simple and straightforward - in order to ensure the survival of the organ after transplantation, the patient who received the organ needs to take immunosuppressive drugs for a long time to prevent rejection from occurring. This is true even for living-donor liver transplants between mother and child.
The Yersinia pestisis in the soup has not been completely eradicated, and the same is true for Hou Huiying. Performing a transplant under such conditions would either waste Tang Wen's donated liver, or Hou Huiying would die of the plague due to a suppressed immune system. This kind of surgery, which is no different from murder, would not be done by any sane doctor.
Looking at Tang Wen, who suddenly stopped, Sun Lien sighed and persuaded, "Don't think so much now, it's true to cure your illness quickly - you want to donate your liver, at least you have to ensure that your donated liver won't make your mother sick again, right?"
Sun Lien also guessed that this was probably the only way Tang Wen could think of to save his mother's life under pressure. Regardless of whether this method is really useful or not, at least the thought itself represents Tang Wen's determination. This is also very important for doctors - not everyone has the guts to actively advise doctors to cut open their stomach and dig out half of their liver to donate to their mother.
This has nothing to do with filial piety or not, and to some extent it doesn't even have to do with guts. People are always in a state of worry and fear. Some people choose to confront these worries and fears, while others choose to avoid them. There is no shame in this, it is just the difference shown by different individuals in the human race. It's like different people react differently to atropine.
There is no shame in refusing it, but it is heroic to take the initiative. Sun Lien patted Tang Wen's shoulder and said seriously, "Now that things haven't come to this point, don't worry." โ
"Can you ...... then," Tang Wen suddenly put forward a new hypothesis, "Transfuse my mother's blood into my body, and then use my liver to filter waste for her? A living human liver is always better than an artificial liver, right?"
Sun Lien almost sprayed a mouthful of saliva on the mask of the P4 protective suit, "Where did you come up with this bad idea?"
"Bad idea?" Tang Wen looked a little puzzled and a little angry, "What's wrong with this idea? My mother and I are both ...... type O blood."
"First of all, you and your mother's blood must not be directly transfused into each other. Especially you can't give your mom a blood transfusion. Sun Lien sighed and began to popularize the relevant blood transfusion knowledge to Tang Wenpu. "You have lymphocytes in your blood. These lymphocytes in your body are not recognized as antigens by your mother's body's immune system. As a result, they will settle in your mother's body, then begin to multiply in large numbers, and eventually attack your mother's digestive and hematopoietic systems. Sun Lien made an analogy, "This process is a bit of a magpie's nest." But this result is much more dangerous. Graft-versus-host disease (GVHD) can be easily caused by blood transfusions between relatives. And once the disease is triggered, the mortality rate is around 90% โ which is much worse than liver failure and even more severe than the plague. โ
"But I often ......act like this on TV dramas," Tang Wen still wanted to argue, "It's just a blood transfusion, isn't there no such risk when other people's blood is transfused into the human body?"
Sun Lien sighed with a bitter face, "I love to act like this in the TV series, and I can't help it." They made a mistake and were scolded by our group of doctors. But if we follow them, we will die. He continued, "Graft-versus-host disease is one of the most serious complications of blood transfusion. Blood transfusions between unrelated people may also be triggered, but the probability is very low, only about 0.1%. For those who are related, the risk of blood transfusion will increase dramatically by more than ten or twenty times. Even if we have to transfuse blood between immediate family members for some special reason, we must first irradiate the blood with a radiation source to kill the lymphocytes inside before transfusing the blood. โ
Sun Lien looked at Tang Wen's face and said seriously, "We have many other methods that we haven't tried, don't be too anxious, things haven't come to this point yet." โ
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"It's not there yet. In the conference room, Wu Youqian, who heard Sun Lien's report, also made the same judgment, "Artificial liver replacement therapy is the best treatment method at present, and as for the family's willingness to donate liver, it is a good thing, but it has not yet reached this step." โ
"That's what I thought, too. Sun Lien nodded, and after getting out of the P4 protective suit, he felt that he was a lot more relaxed all over his body. "But after all, I was trapped in the clean room for three days in a row, and my parents fell into a coma, especially my mother...... I think we should do some psychological intervention for Tang Wen. If it goes on like this, he may not be able to bear it. โ
"This kid isn't very old. Wu Youqian nodded, "You should consider this aspect of the problem." He nodded to the table in front of him, "Put Hou Huiying on the liver transplant list, time can be grabbed a little bit - if her plague has not been completely eliminated by the time there is a liver source, then give up the transplant." โ