"Mr. Wu, I have read a report that 301 has started to study the treatment of Alzheimer's disease with microelectrodes at the hypothalamus/fornix nucleus location. I see that the location of your lower microelectrode is also in the hypothalamus/fornix nucleus......"

Sending the people who came to observe the operation away, several people from the Sword Association Hospital returned to the ward, and Zhou Guohui asked as he walked.

"Director Zhou, you are too polite. Wu Mian was stunned for a moment and said with a smile, "Don't call you a teacher, you're joking with me." ”

"Alas. Zhou Guohui sighed, "Those who reach it are respected, and they should be." After reading the results of your surgery, I have a feeling that patients can recover at least 70% of their function and memory after the anesthetic has completely passed. ”

"When I was in school, Mr. Zhuang, who taught me, was a classmate with you, and you called me that, how can I go back to Concord in the future. Wu Mian scratched his head and said.

"It's all trivial. Zhou Guohui asked, "Do you have any connection with 301?"

"Yes, there has always been a connection. Wu Mian nodded, "In 1985, Professor Turnbull used basal nuclear power stimulation to treat dementia, the study performed left basal nuclear power stimulation on a 74-year-old patient, and found that deep brain stimulation treatment of the basal nucleus could improve the glucose metabolism function of the ipsilateral temporal and parietal lobes, but could not improve the cognitive function of the patients, so this study was delayed for a while. ”

It took 23 years until 2008, when Dr. Hamani discovered by chance that electrical stimulation of the hypothalamus/fornix in a study of obese patients improved memory. After a series of experiments, it was preliminarily determined that the effective target of deep brain stimulation in the treatment of dementia was the hypothalamus/fornix nucleus. ”

"In the phase I clinical trial, electrical stimulation of the hypothalamus/fornix nucleus in patients with mild to moderate dementia for six months to one year showed that electrical stimulation of this area can alleviate or improve the degree of cognitive decline and improve brain glucose metabolism. ”

Later, in 2011, Dr. Ponce conducted a phase II clinical trial study on 42 patients with dementia, and the results of the early safety study showed that the implantation of DBS electrodes into the hypothalamus/fornix nucleus is safe and reliable for the treatment of dementia. ”

"The reason why it has not developed is that there are two difficulties that cannot be solved. The first is that the target of the hypothalamus/fornix nucleus is located below the lateral ventricle, anterior to the third ventricle, through which the implanted electrode must pass.

Since the tip of the implanted electrode is coarser and blunt than the microelectrode, the tip of the implanted electrode is prone to slide along the lateral ventricular wall when passing through the lateral ventricular wall after the microelectrode is recorded, which affects the accuracy of the target. ”

"The 2013 301 research group solved this problem with the trocar-assisted puncture technique. Two years ago, General Medical produced the SIGNA Pioneer 3.0T magnetic resonance system, and the DST surround matrix gradient system is a breakthrough technological innovation in the field of magnetic resonance in the past decade, making accurate positioning possible. ”

"Every technology is built from scratch, and countless people have studied and built it little by little. Wu Mian smiled and said, "I'm just part of solving the last puzzle, nothing." ”

It's nothing, these three words are light, but Zhou Guohui knows how heavy the portions are.

"Teacher Wu, amazing!" Zhou Guohui praised sincerely.

Wu Mian didn't continue to talk to Zhou Guohui about him calling himself a teacher, and he was a little greasy and boring when he talked too much.

Back in the ward, Gao Baixiang squatted in the ward, always observing the patient's postoperative state.

Because the ward of the neurology department has not yet been established, it can only be dealt with here by Gao Baixiang.

The overall diagnosis and treatment process of Jianxie Hospital is not formal, the old driver drives a new car, and Wu Mian does not care very much about the fact that the patient must be hospitalized in neurosurgery.

No, Zhou Guohui "threw himself into the net" and took refuge from the imperial capital.

It's easy to come, but it's hard to leave.

Wu Mian, a chief physician and department director like Zhou Guohui, who is full of professional expertise, and the vice chairman of the Neurology Society, will never let him go. And now, after seeing the patients treated for Alzheimer's disease, he will not leave even if he is chased away in the short term.

"Teacher Wu. When Gao Baixiang saw Wu Mian coming back, he immediately stood up and said hello.

"Well, go and rest. Wu Mian smiled, "I'll watch it here." ”

The patient's postoperative magnetic resonance showed that the current conduction of the cranial nerve bundle had spread widely, and Zhou Guohui said that at least 70% of the function was not untargeted.

It's just that the patient has been sleeping after general anesthesia, and the person has not woken up yet. What is the specific effect, Wu Mian does not want to miss the first-hand information.

Gao Baixiang also knows that he is not a professional neurologist, and with the spread of free surgery for congenital heart disease recently, more and more patients come to consult and be hospitalized.

Cardiac surgery is Gao Baixiang's main battlefield, and with the thoracic surgery department to do mitral valve clipping, Gao Baixiang is also very busy.

Sending off unrelated people, Wu Mian sat beside Chu Zhixi, looking through the glass at the sleeping old man inside.

Yuan Wei was a little nervous, the muscles on his face were very tense in the deep city of the city, there was no trace of a smile, his eyes narrowed into a slit, staring at the grandma in the private room.

"Mr. Yuan, don't be so nervous. Wu Mian said, "The vital signs are stable, and I will be able to wake up soon." ”

"Dr. Wu. Yuan Wei wiped his pants with his hand, and the two water stains were clear, "I also saw the MRI image, although I don't understand medicine, but I know that it can be done by looking at the image." ”

"Hmm. ”

"I'm worried that when my grandma wakes up and sees me, what will happen if she cries? Will it cause arrhythmias? Not long after the heart surgery...... I kind of regretted staying here for 20 more days and letting Grandma get used to it......"

Yuan Wei chattered, completely losing the gloomy and ruthless energy of the former underground chief. Like a family member of an ordinary patient, he expects the results of the surgery to exceed his expectations.

In this regard, people are the same and universal.

"The heart is fine. Wu Mian said, "Relevant examinations have been done before the operation, and the chance of complications is not large." It's not that you said you want to have surgery, but I don't have principled consent on my side. The patient's condition is not good, and you can't be in a hurry. ”

"Huh. Yuan Wei rubbed his hands, and the calluses rubbed against each other, making a rustling sound, like the wind blowing through the sand and stones on the seaside.

"My grandma can remember me. Yuan Wei looked at his grandmother and said, "I don't have any relatives in this world, and I am used to cheating, thinking that I am invulnerable." Grandma gradually didn't know me during that time...... Dr. Goh, you don't know how much I regretted it at the time. ”

"I originally wanted to work hard outside to make Grandma live a good life. I suffered a lot in the first half of my life, but I can't do it in the future. But now life is good, but Grandma doesn't remember anything, and my heart is empty. ”

Yuan Wei revealed his thoughts, and as he was talking, Wu Mian suddenly stood up and strode into the ward.