In an enthusiastic tone, Hirohiro Takahashi wrote an e-mail suggesting a "technical exchange" with Katani to the Nissui headquarters.

In the email, Takahashi Hiroyu talked about the importance of Kaya's special moss, arguing that Kaya had not even realized its full value, and if he didn't take advantage of Kagu's request to take it, they would definitely open their mouths in the future.

On the day Hirohiro Takahashi's email arrived, it was taken seriously by the Nissui headquarters, and he called one after another to inquire about the authenticity.

The next day, Nissui sent a negotiation team and began to contact Kaya and began to bargain.

The proposal for a patent buyout and patent assignment was quickly rejected by Qi Zheng, and the derivative rights of the patent were also restricted, and Jiagu only accepted the patent license.

Correspondingly, Qi Zheng asked Rishui to provide a full set of salmon feed production technology, including high-efficiency attractants, high-energy and low-protein feed, compound enzyme preparations, neutral phytase and other core formula technologies for domestic shortcomings, including but not limited to rapid diagnosis, detection and prevention of salmon diseases......

Hiroyu Takahashi almost jumped up, yes, isn't this called a lion's big mouth?

But Qi Zheng is very stable.

After all, Jiagu's salmon farming is still on the experimental road, and the target is not only Nisui. If you are ruthless, it is not impossible to get the relevant technology from Norway. Moreover, even if Niksui technology is obtained, Kaya cannot copy and use it, and it has to be improved accordingly, and some can only be used as a reference.

However, it is undeniable that even if it is only used as a reference, Jiagu agriculture and animal husbandry can be greatly strengthened in aquaculture technology. This is because it is not only the salmon category that benefits, but also extends to the entire aquaculture sector.

With one side having more options but the other having only one, and the importance of chips is out of sync, reaching a negotiation is easier than Qi Zheng imagined.

Jiagu agriculture and animal husbandry basically got what they wanted, and Rishui also got a full set of breeding technology and related development authorizations for special moss, including the most critical yew extract "inducer"!

Takahashi Hiroyu also learned after signing the contract that the growth rate of special moss is far higher than that of ordinary moss, but its reproduction is inseparable from the induction of yew extract.

——Different from a few years ago, Jiagu Laboratory has conducted more in-depth research on the components of special "inducers" of Turbidium, including which components in yew extract really work, and what is the optimal induction ratio......

Takahashi Hiroyu was taken aback at first, yew extract is not cheap, especially paclitaxel, which has always been a hot commodity in the international market, and the price of high-purity paclitaxel is more than 2 million yuan per kilogram.

Fortunately, after careful consideration, the demand for paclitaxel is low, and although the value of other taxine II., paclitaxin, and diterpenoids is not low, the cost of the "inducer" required for breeding an acre of special moss is more than 10,000 yuan, which is a relatively low cost compared to the tens of thousands or even hundreds of thousands of benefits that may be created by the average annual yield of 100 tons of special moss.

Takahashi Hiroyu is not only able to accept this cost, but also very excited - it is good to have this kind of "controllability", so that it will not pose a threat to the ecology and can get better breeding promotion results.

The "inducer" is also an authorized production, and of course the Rishui side hopes that the longer the authorization time, the better the agreement, but Qi Zheng only agreed to a ten-year licensing contract.

"Actually, instead of producing 'inducers' yourself, you should purchase from us, although our production capacity is limited, I am afraid that we will not be able to provide too much ...... this year," Qi Zheng suggested to Takahashi Hiroyu after signing the contract.

Takahashi Hiroyu shook his head and said proudly: "It's not that I underestimate Jiagu, but in terms of biological extraction technology, our island country has more advantages." ”

Takahashi Hiroyu knows that China's domestic yew industry still cannot fully grasp the purification technology of paclitaxel, and there are not many pharmaceutical manufacturers that have mastered the purification technology of paclitaxel, and many times can only carry out crude purification processing of paclitaxel, and a large number of refined purification must be shipped abroad for processing, such as island countries.

Therefore, he said "not to be underestimated", but in fact, what he thinks in his heart, who doesn't know?

Qi Zheng didn't argue with him either, and said with a smile: "Since that's the case, then I wish you all the best." ”

Qi Zheng's smile was a little strange, and he looked like he was watching a good show.

Takahashi Hiroyu was a little uneasy in his heart, but in the end, he still didn't change his original intention.

After returning to the island country, he took the special moss seedlings provided by Kagu and opened the first special moss breeding farm in the waters of Hokkaido.

Then, Takahashi Hiroyu realized that something was wrong.

Although the growth rate of special moss in the waters of Hokkaido is faster than that of ordinary moss, it is at least one-third slower than the Kagaya moss farm he saw.

This is not just a matter of growth rate, Jiagu can harvest a stubble in less than two weeks, but the daily water can not harvest a stubble in three weeks, and cumulatively, the average annual yield per mu is more than one-third lower.

He didn't know that Jiagu's farm had the "birth" of the "Green Bamboo Lark Array", but according to Jiagu's feedback, he felt that it was a problem with the sea environment.

——He found out that the sea water in the sea area where it is located was eutrophicated when he inspected the Jiagu Hu moss farm, and at that time he laughed at China's serious environmental pollution.

But that's not the most serious thing, the bigger problem now is that the Japanese water is in the supply of yew extract "inducers"!

......

After returning to China, Takahashi contacted a friend from the island country's biomedical company to establish a supply chain for yew extract.

But......

"Cell culture to produce yew extracts like paclitaxel is a good idea, but it's not that easy. His friend said bluntly.

"Is it technically unattainable?" asked Takahashi Hiroyu.

In his opinion, the idea of planting yew in large quantities to extract paclitaxel, for pharmaceuticals or as an "inducer", is wrong.

Paclitaxel is found in the roots, bark, twigs and needles of yew. However, the content is too low, the highest is only 2/10,000, and yew resources are so scarce, so it is urgent to efficiently obtain paclitaxel and other extracts through modern scientific and technological means in different ways.

For example, some large international pharmaceutical companies have found a lot of Chinese herbal medicines, and then extracted the chemical template of this Chinese herbal medicine that can cure diseases, and then synthesized them by industrial methods, so as to achieve large-scale industrial production.

"No, the chemical synthesis of paclitaxel, or the production of paclitaxel from yew cell culture, can be achieved in the laboratory, but many key technologies have not been solved, the cost is extremely high, and it will take a long ......time to apply them to the industrial production stage," his friend struck mercilessly.

Okay, the industrial production of yew extract can't be done for the time being, Takahashi Hiroyu has been mentally prepared, so let's rely on trade procurement.

However, "even if it is a purchase, it does not mean that it can be purchased immediately, and it is impossible to purchase in large quantities ......," his friend continued.

"As you know, the reason why yew extracts such as paclitaxel are rare is because they are difficult to produce on a large scale. Most of the paclitaxel is found in the bark of the tree. How many years does a tree have to grow? Ten or eight years old trees are very small, how much bark can there be, and when the bark is peeled, the yew tree will die. ”

"In this case, many yew companies can't stick to it. However, from the perspective of the international market, paclitaxel products have maintained a growth rate of 20% in recent years - the degree of supply tension can be imagined. The supply of extracts such as paclitaxel is either a long-term contract or an early ......"

Hiroyu Takahashi listened, and his heart began to grow cold.

- He underestimated the popularity of yew extract.

Don't look at the "inducer" needed to breed one acre of special moss, but if the breeding area of special moss rises to 10,000 mu, 100,000 mu, or even one million mu...... The amount of yew extract needed is terrifying.

Not to mention whether it can compete with the medical community, as an "inducer" of moss reproduction, the first thing is to consider the cost. What's the point if the cost is too high for the sake of snapping up?

Seeing this, his friend made a suggestion: "But now there is a good opportunity. Well, you know Jiagu Group, which is becoming a rising star in China's yew industry, with 20% of the area planted in China. It is reported that Jiagu has cultivated more excellent yew varieties, and the paclitaxel content is much higher than that of normal varieties, it is difficult to say whether it is true or false, but our company is planning to contact Jiagu for a while......"

Takahashi Hiroyu opened his mouth and suddenly remembered Qi Zheng's suggestion before returning to China - to purchase "inducers" from Jiagu.

Everyone knows that "inducers" are the key to the development of special moss. Takahashi Hiroyu didn't want the "life gate" to be controlled by Kaya, so he naturally rejected Qi Zheng's suggestion.

Now it seems that you still can't escape Jiagu's routine?

Yes, Hiroyu Takahashi feels that he has been tricked by Qi Zheng, and he has evidence!

The yield does not meet expectations, if you want to produce benefits, you must find a way to reduce costs, and the yew extract "inducer" occupies a considerable proportion of the cost, if you do not find Jiagu, the cost is difficult to come down; if you rely on Jiagu, you will be pinched by Jiagu.

Moreover, he has not forgotten that Qi Zheng said this - "The production capacity is limited, and I am afraid that I will not be able to provide too many ...... this year"

What does this mean?

The problem is that Jiagu is still clean - the formula is provided, the breeding method is provided, and the algae seedlings are also provided, and you can't reduce the cost, who is to blame?

If it is true that Jiagu has bred better yew varieties, then Jiagu is expected to become the world's largest supplier of yew extracts. In other words, at that time, whether the special moss industry can grow up depends purely on Jiagu's eyes - at least before the industrial synthesis of yew extract.

Ma's, it's scary to think about!

......