Chapter 091: Prions

Then Zhou Wen spent 200 points to learn the formula of biological anti-wrinkle cream.

Zhou Wen checked it, and sure enough, as expected, he also needed to buy a special biological enzyme additive from the system store.

Let's leave this one for now.

After calming down, Zhou Wen thought about it a little and upgraded the pathology to LV2.

Pathology and pharmacology are complementary to each other, and from the perspective of pharmaceutical science, only by understanding more about the causes, mechanisms, development laws and morphological structures of the body in the process of human diseases, can we better study drugs.

With the upgrading of [pathology], a large amount of knowledge poured into Zhou Wen's brain.

The pathological knowledge stored in the brain quickly became vivid.

In the past, I only knew one thing and didn't know the other, but now I have a deeper understanding.

Combined with pharmacology, he has now truly become a brilliant doctor.

And it's a general practitioner.

He understands the causes and treatment options for most routine diseases.

For example, inflammation, cardiovascular diseases, respiratory diseases, digestive diseases, lymphatic hematopoietic system diseases, immune diseases, urinary system diseases, etc.

Zhou Wen was so excited that he almost didn't jump.

It may be difficult for outsiders to understand how he is feeling right now.

It's like a scumbag, knowing the content of the college entrance examination in advance, and then memorizing all the knowledge points and solution answers in advance, waiting for life to counterattack, what is this feeling?

It's just refreshing?

And Zhou Wen "memorized" more than one answer for the college entrance examination, he even "memorized" the answer to the university exam.

This feeling of taking shortcuts in life made Zhou Wen's three hundred and sixty pores stretch.

He now wants to find someone to see them, such as orthopedics......

Sunday morning.

It may be because of the rain yesterday, but today the weather is exceptionally good, the fiery red sun rises from the sky early, scorching the earth, and the air gradually begins to heat up.

At eight o'clock in the morning, Zhou Wen took a bus to Tianhai Intellectual Property Agency Co., Ltd. on Jianghai Road.

I met the general manager Meng Xiang in the office.

Meng Xiang is very young, only in his early 30s, with a haircut, wearing a red striped shirt + black trousers, and a pair of gold-rimmed glasses on the bridge of his nose, with an elegant temperament, he looks like a Kochi.

"Hello Mr. Zhou~"

"Hello Manager Meng. ”

The two of them exchanged a brief greeting, and then sat down separately.

Zhou Wen took out the printed patent application specification from his computer bag, "Manager Meng, take a look." ”

"Okay. Meng Xiang took the thick stack of instructions, pushed down the frame on the bridge of his nose with his middle finger, and then turned to the first page to read.

Meng Xiang looked at it quickly, and he glanced at ten lines.

Like those process flow structure diagrams, formulas, etc., just skip it.

35,000 words, plus pictures and formulas, etc., a total of nearly 30 pages, Meng Xiang saw the end in five minutes.

Naturally, someone will review those things one by one, and what he needs to know is, what is it that comes out of such a long patent specification?

Where the hell is it?

"Product effect description: After the refining and improvement of this process, the effect of the powerful version of sildenafil tablets will be increased by 200%~300% on the original basis. ”

Meng Xiang: "............"

Meng Xiang felt speechless.

He didn't know what to say anymore.

For the sake of the other party's classmate, who is the chairman's baby daughter, he ran to the company on Sunday and waited for the other party for more than an hour, but what he was waiting for was this fantastical prescription...... Process.

What international jokes?

What do you think you are, and you still improve sildenafil?

Since the discovery of the effect of sildenafil in the treatment of ED in the early 90s, hundreds of pharmaceutical engineers have devoted themselves to research and development.

The process has been tested for a long time.

You casually say that you have improved the process of others, and the effect has been increased by 200%~300%.

Do you think too highly of yourself, or do you look down on Pfizer's pharmaceutical engineers too much?

"Ahem~" Meng Xiang coughed and said, "That, Mr. Zhou...... I don't think there is a need to apply for this patent. ”

Zhou Wen was puzzled: "Why?"

Meng Xiang stretched out his hand and pushed down the frame, and said euphemistically: "I don't think it's possible to have this process patent."

You must know that sildenafil took Pfizer nearly 10 years to develop, and the post-marketing process has undergone 20 years of continuous improvement, and it is not casual to surpass them. ”

Zhou Wen smiled.

Without the results of clinical trials, anyone who sees the specification of this patent application will think that it is fantastical.

He didn't argue, and said with a smile: "What Manager Meng said is true, but I still want to register a patent." ”

Meng Xiang knew that a person who could write a 35,000-word patent application specification could not dispel the idea of registering a patent with just three or two sentences, so he did not persuade him again.

"Since you insist, then do as you say. ”

Zhou Wen asked, "What about the cost?"

Meng Xiang thought about it for a while and said: "To be honest, if it is calculated according to the value in your patent specification, the agency fee is very expensive, but you ......

In this way, all the expenses are added together, and you can give a total of 150,000. ”

"150,000 ...... It's still a friendly price, these top agencies, the price is really expensive. ”

Zhou Wen said secretly in his heart and asked, "Do you think this will work, I will pay 10,000 yuan first, and then give the rest later?"

Meng Xiang nodded, "Yes." ”

Then the two parties signed an agency agreement, and Zhou Wen gave a copy of his ID card to Meng Xiang.

After that, Alipay transferred 10,000 yuan to Tianhai's company account.

Even if the agency is done.

The rest is handled by Tianhai Law Firm, and he just needs to wait to get the patent certificate.

Zhou Wen got up and said goodbye.

Meng Xiang sent him to the elevator all the way, and only turned around and went back to the office after watching the elevator go down.

On the way, I picked up the phone and dialed out.

"Hey, miss, it's done...... He's patented...... A total of 150,000 ......"

As soon as Meng Xiang said the price, a roar suddenly came from the phone, "What, 150,000, so much?"

Meng Xiang smiled bitterly: "This price is already very cheap, if it is calculated according to the market price, at least 1 million agency fees." ”

"Don't be so black-hearted, okay? How can he have so much money? And you said that it is impossible to succeed, why do you have to cheat other people's money...... That's 10,000. ”

"I didn't cheat him on his money...... And the contract has already been signed, and it's hard to change. ”

"Then I don't care, you can do it yourself. ”

"I ...... ......"Meng Xiang was just about to speak, but the phone was hung up.

Meng Xiang looked at the mobile phone that hung up, and said depressedly: "It's really true that the girl's elbow is turned outward. You must not have a daughter in the future. ”

……

As soon as Zhou Wen arrived downstairs, he received a call from Yang Liqun, asking him to go to the testing center.

Zhou Wen hurried to the testing center.

Yang Liqun handed over an electrophoresis test report, "Take a look." ”

"What's wrong?" Zhou Wen took it and looked at it, and found that it was a very rare "prion".

Zhou Wen's brain quickly appeared with knowledge about prions.

Strictly speaking, a "prion" is not a virus, it is a toxic biomolecule that contains only proteins and no "nucleic acids", so it is also called a "prion protein".

Prions, which are currently recognized worldwide as a misfolded protein, have no accepted three-dimensional structure.

As a self-replicating peptide chain, prion proteins may be older and more primitive biomolecules than nucleic acid chains.

At first, it may have been an accidental "combination of amino acids" that gave it the initial characteristics of life such as "replication".

However, although it is not a virus, prions are no less terrible than viruses, and even more so.

The famous "mad cow disease" (Creutzfeldt-Jakob disease) is caused by prions.

A variety of neurological diseases, such as "Alzheimer's disease" and "Parkinson's disease", are inextricably linked to prions.

The clinical manifestations of these disorders are generally central nervous system disorders such as motor disorders, tremor (shaking of the hands), postural instability, dementia, hyperesthesia, and behavioral abnormalities.

Yang Liqun said: "The clinical manifestations of this case are very special, and he will often laugh uncontrollably......

——

ps: I'm sorry, please......