"Huanyu is said to have completed the development of the active compound and is currently undergoing pharmacological evaluation. ”

Lang Yongfeng, executive director of Tianfeng Zhengda, looked at the paper data on the table and said.

As a pharmaceutical company that started with generic drugs, Tianfeng Zhengda has also invested a lot of money in new drug research in the past two years.

However, the development of new drugs does not produce results in a short period of time, nor does it necessarily lead to results.

Even in the clinical trial stage, as drug evaluation becomes more and more difficult, there are fewer and fewer new drugs that can pass all phase 3 clinical evaluations and go on the market.

Part of the reason is that it is becoming more and more difficult to develop new drugs that are better than the comprehensive evaluation of existing drugs on the market, such as the FDA (Food and Drug Administration) approved only 35 new drugs last year.

For example, a second-class new drug that Tianfeng Zhengda invested heavily in research and development has entered the second phase of clinical trials, but it died, and all the $75 million invested in the early stage was lost, which is very miserable.

Of course, drug R&D is also an industry with high investment and high returns.

Once a drug is successfully marketed, the rewards are staggering.

There's a term in the industry called "blockbuster", which refers to drugs that sell more than $1 billion a year.

An extreme example is Pfizer's patent-protected lipid-lowering drug Lipitor, which had global sales of a staggering $10.133 billion in 2010.

Hearing Lang Yongfeng's words, a four-eyed middle-aged man pushed the frame on the bridge of his nose and said: "This company's R&D capabilities are very strong, and it is almost a sure fact that it has entered the clinical trial stage;

Another man with a three-fold beard, smoking a cigarette, said: "I think you are all unfounded, where is this, and the clinical trial has not even started, what is there to worry about." ”

Lang Yongfeng shook his head and said: "You are wrong, I am not unfounded, He Junfeng, the chief scientist of Type B of the Academy of Sciences, has joined their team, do you know what this means?"

You may not know He Junfeng, he is very arrogant, when Mr. Xie wanted to invite him to be the chief expert consultant of our company, and even offered an annual salary of 10 million + reward equity, but he didn't look at it and refused directly.

The fact that he was able to join Cosmos Creatures only meant that there must be something that he couldn't refuse. ”

The four-eyed middle-aged man said, "What Mr. Lang means...... Has Oneworld made a breakthrough discovery in the treatment of hepatitis B?"

Lang Yongfeng nodded affirmatively: "Yes!"

……

Kapok City, Sichuan Province, Ruiyang Pharmaceutical Factory, Science and Technology Park Avenue.

Ruiyang is only a very small pharmaceutical factory, mainly engaged in preparation processing plants, with a total of more than 30 employees, and four technicians.

In addition to being responsible for the daily production of the factory, these technicians will also conduct some drug research.

Mainly analgesics.

And the reason why they will study painkillers is mainly because of the boss and technical director Fu Le.

Fu Le, a former anesthesiologist, left his job seven years ago due to some things, entered the pharmaceutical industry by chance, and then began to study painkillers out of personal interest outside of work.

However, today, Ruiyang Pharmaceutical Factory is about to close down, because the OEM business continues to shrink, the factory can no longer continue to support, and has to close.

At this time, the four technicians in the laboratory looked at the experimental equipment packed on the ground, all with reluctant expressions, but it was useless to be reluctant, they always had to live and had to find another way to make a living.

It's just a pity that the boss Fu Le, he is a person with ideals and sentiments, and he has paid practical actions for his dreams.

"Let's go, let's say goodbye to the old man. ”

"Go ......"

A few people looked at the experimental equipment on the ground again, sighed, and left the laboratory.

In the office, a man in his forties with a thin face was calculating the company's assets according to the documents given by the accountant.

After some accounting, after removing various expenses, after selling all the equipment, not only did not have a penny left, but also owed more than 100,000 yuan.

This man is naturally Fu Le, the owner of Ruiyang Pharmaceutical Factory.

Fu Le smiled bitterly, in May 2013, it has been 7 years since today, and he is still busy with nothing and nothing in the end.

Fortunately, his wife had already divorced him and took the children away, otherwise he would not even have a place to stand with him.

"Very good!"

Fu Le picked up his mobile phone and called the second-hand equipment recycler, "Hey Boss Zhang, come and pull the equipment......"

After making the call, Fu Le closed the computer and was about to leave, but at this moment, the phone on the desk rang.

"Hey, hello, who is it?"

A very infectious baritone voice came from the other end of the phone, "Are you Mr. Fu?"

Fu Le: "Yes, I am, who are you?"

Baritone: "I am Tong Miao, the evaluator of the Huanyu Biological Research Foundation, after we received your application, we evaluated your company and the experimental project, and now we have some questions I would like to ask you, is it convenient for you now?"

"Huanyu Foundation?" After listening to the other party's words, Fu Leleng paused for a moment, and then suddenly remembered that he seemed to have filled out some kind of application last month.

"That's right, the Global Research Grant. ”

Fu Le suddenly remembered.

Last month, he applied for a $1 million research grant from the Global Research Foundation.

Although I knew that there was little hope, I was desperate at that time, so I filled in some information with the hope of just in case.

I didn't expect the Foundation to call me.

"Well, you ask. Fu Le unconsciously, even his words became respectful.

There is no way, who makes the other party the God of Wealth, whether Ruiyang can continue to maintain it depends on whether the other party can loosen his mouth.

Tong Miao: "The whole phone call was recorded. ”

Fu Le: "Yes! ”

Tong Miao: "Okay, let's start now." I read in the application instructions, you have been an anesthesiologist for 11 years, why didn't you do it in the end?"

Fu Le: "Because of emotional problems." ”

Tong Miao: "Then why did you think of researching painkillers?"

Fu Le: "Because I believe that any true anesthesiologist wants to develop an analgesic that can effectively block pain without producing euphoria. ”

Tong Miao: "I don't understand too much, can you explain the reason in detail?"

Fu Le: "Okay! It sounds a bit nonsensical, analgesics are a matter of responsibility, wouldn't it be better to provide a sense of euphoria and refreshment?"

However, the countless problems in the world lie in this feeling of "making you cool".

Euphoria is a high-sounding word, but it's almost one with the words "smoking D", "D addiction", and "withdrawal reaction".

What you may not know is the sad fact that the analgesics that save hundreds of millions of patients with cancer and severe pain, and are also necessary for surgery, are being abused by pleasure-seeking addicts and become the "D product" of talking about it.

For example, the most commonly used analgesics are opioids, and opioids here are actually euphemisms for English translations, but the exact name is Y-tablets.

Opioids originally referred to resin exudate extracted from poppy capsule, and then transitioned to artificial semi-synthetic and fully synthetic anesthetic and analgesic drugs with the development of the chemical industry.

Morphine, buprenorphine, fentanyl, demerol, tramadol, methadone, etc., as well as various painkiller plasters and emulsions, many of which also contain opioids.

As a strong analgesic, opioids bind to opioid receptors after entering various parts of the nervous system, which can quickly increase the body's pain threshold, reduce the body's perception of pain, and produce a powerful analgesic effect.

But it also has the effect of inducing a special euphoria and a very pleasant, comfortable feeling in the user, which is the root cause of the abuse of these drugs.

Euphoria and addiction are almost inseparable, and supernormal pleasure is pleasure and hell.

Cool is not a problem, the problem is to be cool all the time.

The subjective human desire to seek intense stimuli is almost endless.

After experiencing a pleasure that is far beyond imagination, any ordinary stimulation is like tickling, and once the pleasure threshold is raised, it is difficult to be suppressed.

The so-called difficulty in making money from luxury to frugality, and wanting to be cool after being cool is addiction.

An addictive word has ruined countless people.

As an anesthesiologist, I am saddened to see that many of the drugs that were originally invented for the benefit of mankind are being abused as product D, which not only stigmatizes the drug, but also commits a serious crime against patients with extreme pain and legitimate need for analgesia.

For example, chloramine-tong, it is a very excellent short-acting analgesic in the field of pediatric anesthesia, with fast onset, fast metabolism, and the function of dissociative anesthesia, which is very suitable for pediatric short-acting and fast surgery.

But it's now called K-powder, and no one knows it used to be a good helper for anesthesiologists.

Because of this, I would like to be able to understand the entire pain signal as soon as possible and develop an analgesic that can effectively block pain without relying on opioid receptors......"