Chapter 156: Mutagenesis Breeding

Hearing Zhou Wen's words, Zhu Linqing secretly said "bad" in his heart.

Listening to the other party's meaning, it is clear that some companies have offered more favorable conditions.

After hanging up the phone, Zhu Linqing looked at the new version of the patented technical description of sildenafil granules on the computer, and his brows couldn't help frowning.

Although the conditions offered by Yaoming Kangde are harsh, they can be regarded as "conscience prices" in the industry, and ordinary enterprises really dare not say that they can be better than the conditions given by Yaoming Kangde.

Since this company dares to grab food from the tiger's mouth, it must also see the huge market potential of this drug.

Even, sildenafil granules have been made in advance according to the process flow, and preliminary clinical trials have been done, and the efficacy is very significant, so I can't wait to cooperate with Zhou Wen.

After some analysis, Zhu Linqing believes that his guess should not be far from the truth.

Thinking of this, he immediately picked up the phone and called the laboratory.

"Hey, Director Shao, I sent you a document to your mailbox, you follow the above technical process, make it for me as soon as possible, and within 48 hours, I will get the efficacy evaluation report." ”

Two days later......

Zhu Linqing got the efficacy test report.

Skim through the previous toxicology test data reports and look directly at the results.

Number of participants in internal testing: 6.

2 were mild, 2 were moderate, and 2 were severe.

According to the test, the new version of sildenafil granules has a particularly significant effect on the treatment of symptoms, and the 6 participants in the test have very bright data......

Zhu Linqing looked at the test report, and his intestines were repentant.

With such a drug effect, if the side effects are not too obvious in clinical trials, it is almost 100% to replace the old sildenafil tablets after returning to the market.

"No, you can't just give up......"

Zhu Linqing immediately decided to have a detailed interview with Zhou Wen.

No matter how bad it is, you have to find the company that cuts off the beard and get a piece of the pie.

......

On the other hand, Xu Yuting came to Jiangzhou City on the afternoon of the 30th.

At three o'clock in the afternoon of December 31, I met Zhou Wen in the office of Hengfeng Building, Jinhu District.

Exceptionally, Chen Zhiyuan and lawyers from both sides were also present.

"Hello Mr. Xu"

"Hehe, hello"

The two men shook hands and looked at each other closely.

In Zhou Wen's eyes, Xu Shuangyu, the sister-in-law, has an outstanding demeanor and elegant temperament, and is different from the so-called strong women, Xu Yuting is full of the personal charm of a female entrepreneur, which makes people feel very good.

In Xu Yuting's opinion, Zhou Wen looks much more real than the radiant genius boy on the podium.

This is Chen Zhiyuan, the general manager of Huanyu. ”

"Hello Mr. Chen. ”

"Hello Mr. Xu, please be seated. ”

"Well, okay......"

Xu Yuting is a standard businessman, and Zhou Wen is also thinking about how to maximize the benefits of patents.

So there was no too much politeness, and after a few simple greetings, I went straight to the point.

In fact, Xu Shuangyu had already roughly explained Long Kang's conditions before.

Zhou Wen authorized the new sildenafil granules to Longkang, and Longkang was responsible for the promotion and operation.

The money earned is divided into ninety.

Long Kang is ninety, Zhou Wen is one.

Don't get excited.

Zhou Wen: This one percent is one percent of total sales.

Remember, it's "sales".

In other words, if the new version of sildenafil granules reaches 1 billion in annual sales after being listed, Zhou Wen will get 100 million.

10 billion is a billion.

Although Longkang Group took ninety percent, they were all responsible for clinical trials, new drug marketing applications, and promotion and sales.

Secondly, the profit sharing of downstream dealers is also deducted from the ninety percent, so in fact, the profits obtained by Longkang are greatly diluted.

In addition, there is a guarantee agreement between the two parties.

After signing the agreement, regardless of whether sildenafil granules can be marketed or not, and how the sales after the market are made, the annual patent fee of 20 million must be paid to Zhou Wen included in the sales.

Because of this, after removing all the costs, Longkang basically couldn't make money in the first three years. And if you can't make money, it means losing money.

Therefore, Longkang is betting on the later market.

won the tender model of the club, and lost to work in the sea.

Xu Yuting and Zhou Wen negotiated some details of the contract, but the overall direction remained the same.

After half an hour of research and discussion, Chen Zhiyuan, on behalf of Zhou Wen, officially signed the authorization contract with Long Kang.

Zhou Wen's authorized subject is not him personally, but Huanyu Biotechnology Co., Ltd.

Because he is a technology shareholder, he has handed over the patent rights to Huanyu Biotechnology Co., Ltd. as a full agent, and then authorized by Huanyu to Longkang Group.

After the renegotiation of the return shares, the patent right will be changed to the main body of the company.

This can not only enhance the intangible assets and corporate image of the enterprise, but also involve the application for government projects, patent funding, and reasonable tax avoidance......

All in all, there are many benefits.

"Mr. Xu, happy cooperation. ”

"After the happy cooperation and New Year's Day, the 20 million guaranteed patent fee will be paid to the account of Huanyu Company first. ”

"Well, okay......"

Then Zhou Wen sent Xu Yuting downstairs.

When she arrived at the door of the company building, Xu Yuting suddenly smiled and said, "By the way, Pisces will return to China next week." ”

While speaking, Xu Yuting looked at Zhou Wen's expression.

Zhou Wen smiled and said, "Well, she told me, and I will invite her to dinner when I come back." ”

Xu Yuting didn't see anything on Zhou Wen's face, and said with a bright smile: "Then I'll go first." ”

"Okay, Mr. Xu, you go slowly......"

The Spinner that Zhou Wen sent Xu Yuting to ride slowly started, and then disappeared from sight.

He turned and went upstairs, grabbed some things, and prepared to leave.

Chen Zhiyuan came over and said with a smile: "Oh Lao Zhou, last time, that Xiao Min kept asking me why your phone couldn't get through, did you block her?"

Zhou Wen said: "No, I just just quoted a number." ”

Chen Zhiyuan bared his teeth and said: "Awesome, you have already mastered the essence of not taking the initiative, refusing, and not being responsible. ”

"Fuck off, it's because you're a fucking depraved guy. ”

"Don't say that. Everyone has a love for beauty, at most it is a little bit of fraternity, how can it be called degenerate?"

"Okay, okay, you go on to fraternity. I went to the lab."

Zhou Wen took the car keys and prepared to leave.

Chen Zhiyuan said: "Lend me your car, I'll wait to meet a customer, my car is too bad." ”

"Then give me your car. Saying that, Zhou Wen threw the key to Chen Zhiyuan.

Chen Zhiyuan spread his hands and said, "I lent my car to someone in the company to do business." ”

Zhou Wen was speechless and said, "Then what am I driving?"

Chen Zhiyuan smiled and said, "You drive a Ferrari." Tens of millions of cars, you can't throw them in the garage every day. ”

Zhou Wen: "So sassy bag, how can I drive to the laboratory?"

"Or ...... I'll borrow an electric car from Xiao Liu at the front desk to drive it for you?"

"Roll"

"Okay. Chen Zhiyuan took the key and left.

"Let's be sassy. Zhou Wen didn't bother to call Didi Che, so he took the key to the Ferrari 12 from the office and went downstairs.

......

No. 404, Jinhu District Industrial Park, Huanyu Institute of Biotechnology.

In the open office, seven or eight people, including Wang Hua, Sun Xin, Song Xuezhang, Bai Xuan, and Luo Chunlei, were studying and discussing together.

This is the person in charge of many doctors elected by themselves, and they are very good in character and academics, and they also have certain leadership skills.

Everyone agrees.

The technology they are discussing at this time is "mutagenesis breeding", which is one of the next key projects to be developed by Huanyu.

The so-called mutagenesis breeding technology is actually similar to the genetic modification technology of rice aphids that Zhou Wen studied before.

It is to use physical, chemical and other factors under artificial conditions to induce mutations in objects, and select from them to breed new varieties of animals, plants and microorganisms.

For example, chemical mutagenesis is more commonly used alkylating agents, such as ethyl methanesulfonate and diethyl sulfate.

The method of using it is simple, dilute it to a certain concentration, and then put the seeds that need to be mutagenesis in and soak them for a while.

The mutagenic seeds are then germinated, plants with the desired trait phenotype are selected, and mutants are selected for stable inheritance through self-breeding or hybridization.

Of course, the amount of sifting is huge, and in the case of tomatoes, it is sometimes necessary to sift through tens of thousands of seeds to find the desired trait.

There is also physical mutagenesis.

The principle is to use a variety of radiation to accelerate the mutation rate of plants, among which the commonly used are rays, rays, rays, rays, rays, ultraviolet radiation, etc., these operations require special equipment.

One of the more well-known is the laboratory of the Radiation Breeding Institute of Japanese Bene, which has built a tower for radiation treatment, surrounded by a test field.

After some discussion, two research targets were decided: grapes and strawberries.

These are two kinds of fruits that are commonly found in greenhouses in the province of Sudong.

Just when they were about to assign tasks, footsteps came from the door of the conference room, and everyone subconsciously turned their heads to look, it turned out to be Zhou Wen coming.

"Zhou is here. ”

"Good for the week. ”

"Hehe, everyone is here, sit and sit ......"

Zhou Wen stretched out his hand and motioned for everyone to sit down, and then sat down next to Wang Hua, "What are you discussing?"

As he spoke, he had already seen the research plan on the table, as well as the relevant materials about the mutagenesis technique.

Song Xuezhang, who was sitting opposite Zhou Wen, said: "We have just selected two goals......

As Song Xuezhang spoke, four or five task prompts suddenly sounded in Zhou Wen's ears one after another.

Zhou Wen: "......"

He'd never been given so many tasks at once.

Open the system tasks and look at it, there is a long row of new tasks on the list.

Task 1: Radiation breeding.

Requirements: Establishment of a grape radiation breeding research group.

Rewards: 2000 subject experience, 1000 points, and a bronze chance to draw

Task 2: Chemical Breeding.

Requirements: Establishment of a research group on chemical breeding of grapes.

Rewards: 2000 subject experience, 1000 points, and a bronze chance to draw

Task 3: Radiation Breeding 2

Requirements: Establish a strawberry radiation breeding research institute......

The requirements for mission 3 and mission 4 are similar, except that the requirements change from grapes to strawberries.

The first few tasks, in his opinion, are sent by the system.

But the latter ones are more exaggerated.

For example, task 5 requires the cultivation of grapes with an average of 50 grams per grain.

China's largest grape variety, the vine nim grape, has an average of only about 2,230 grams per grain and the largest is only 35 grams, which has nearly doubled.

Task 6 requires the cultivation of strawberries with a maximum of 500 grams per seed.

This is even more exaggerated, the world record is only 231, which has more than doubled, and the system really looks up to him......

ps: I'm sorry, please......