After answering the interview questions from the reporter of the People's Daily, Shen Qi accepted interviews with several other media, both domestic and foreign.

A media asked: "Professor Shen, you mentioned in the report just now that the research results of macrocyclic compounds are reflected in practical applications, and a new class of macrocyclic compounds triazaoctenes have been synthesized, and we have inquired in the official notice of the CFDA that triazaoctenes have been approved to enter phase I clinical trials." ”

Shen Qi: "Yes. ”

Media: "We also learned that your wife participated in the phase I clinical trial of triazaoctene as a subject, is this true?"

Shen Qi: "Yes. ”

Wow~

Yikes~

Huh?

The media friends at the scene made a variety of voices.

Soon, the news was launched.

On the second day of the IUPAC World Chemistry Congress, Academician Shen Qi publicly reported for the first time the research progress of "macrocyclic compounds, novel rearrangement reactions and related chemical drug applications", which aroused enthusiastic responses. ”

According to chemists at home and abroad, the research results of Shen Qi's team are expected to win this year's Nobel Prize in Chemistry. ”

"The actual product of "macrocyclic compounds, novel rearrangement reactions and related chemical drug applications" is a chemical drug called triazaoctene, which has entered phase I clinical trials in China, and Shen Qi's wife is participating in clinical trials as a subject. ”

The media reports were fairly objective, and they reported in a factual manner.

There are many kinds of comments.

"Take your wife for human experiments?"

"I can't afford to mess with it. ”

"I believe that Academician Shen must have enough confidence to do this. ”

"In fact, Academician Shen did this scientific research project in order to cure his wife's illness, and then accidentally won a Notional Award......"

"Don't make a fuss, although type R anemia is a rare disease, there is more than one patient, Mrs. Shen is not the only patient, Academician Shen is doing this to save patients all over the world. ”

"In any case, I wish Academician Shen success in his scientific research project and a recovery for patients all over the world. ”

……

At two o'clock in the afternoon, Shen Qi presided over a Q&A meeting on "Application of Macrocyclic Compounds, New Rearrangement Reactions and Related Chemical Drugs" in the No. 2 Conference Hall of the Capital International Conference Center.

Conference Hall 2, which can accommodate more than 80 people, was full, and some late scholars could only stand, and the total number of people present exceeded 100.

There are more than 1,000 participants at the IUPAC World Congress of Chemistry, and there are only about 100 scholars who are really famous and something, almost all of them are here.

"Everyone, you can ask questions. Shen Qi said.

The first person to ask the question was a white scholar: "Hello Professor Shen, I'm Charlie Manson from Caltech, the macrocyclic compound with the structure of triazaoctene conforms to the macrocyclic compound theory system you constructed, but we all know that there are many kinds of known and unknown macrocyclic compounds, how can you ensure that your theory can be adapted to all or most of the macrocyclic compounds?"

It was a very good question, it spoke to the minds of the majority of the participants, and it was a representative question.

Shen Qi replied: "The method I use is very traditional, I get the theory through experiments, and then put the theory into experiments to verify it. Mr. Manson is right, how can I prove that my theory can be adapted to all or most macrocyclic compounds? Experiments, yes, experiments. ”

"The paper "Macrocyclic Compounds, Novel Rearrangement Reactions and Related Chemical Drugs" has been published, and it can be said that our team has unreservedly demonstrated the theoretical system, reaction mechanism, and practical application cases that we know. It is not possible for all macrocyclic compounds to be validated in our lab, so please help us with the verification. ”

"If there is a research team that happens to be working on macrocyclic compounds, then I hope that our "Macrocyclic Compounds, Novel Rearrangement Reactions, and Related Chemical Drug Applications" will help your experiments, or prove it to be wrong. Thanks, next. ”

The participating scholars asked questions one after another, and Shen Qi answered them one by one.

The Q&A meeting went very smoothly, and everyone had friendly exchanges and harmonious discussions.

Two hours passed quickly, and Shen Qi's answers to various questions satisfied most scholars.

In fact, Shen Qi has been waiting for a question from one person, Mr. Tachibana.

However, Mr. Tachibana did not seem to be present at the Q&A session.

At the end of the five-day IUPAC World Chemistry Congress, "Macrocyclic Compounds, Novel Rearrangement Reactions and Applications of Related Chemical Drugs" was officially published in the conference proceedings for scholars from all over the world to study and verify.

Shen Qi's chemistry grade has still not been upgraded to level 14.

"Maybe I have to wait for scholars all over the world to verify that there is no problem before I can upgrade to level 14?" Shen Qi had a brief communication with the system.

The system did not respond.

Yanda People's Hospital.

The triazaoctenein clinical trial research team has begun to administer drugs to subjects, including Oye.

Typically, a drug is in a phase I clinical trial and does not expect any clinical efficacy. When conducting a phase I clinical trial, the safety, rights and health status of the subjects are mainly considered, as well as the scientific information that can be obtained from the clinical trial.

Phase I clinical trials are first done with a tolerance test, that is, to obtain the dosage range that the human body can tolerate the new drug.

In the tolerance test, Ou Ye's daily routine is to take medicine, do electrocardiogram, blood/urine routine, liver and kidney function biochemical tests, RBC, HCT, etc., every day, very regular.

Shen Qi's focus of work and life during this period was all in the hospital, and he paid close attention to all the data and details of the phase I clinical trial of triazaoctene.

Shen Qi carefully studied the test data of all subjects from the first day to today, and focused on the test data of Ou Ye.

"The routine examination is normal, RBC, HCT, hemoglobin concentration, and blood creatinine have not found any abnormalities, and if there is no abnormality, it is good news, wife, how do you feel about yourself?"

"I ...... I feel so empty......"

"This is a normal reaction, and if you are a healthy volunteer, you will be weak if you take medicine every day and do so many tests. I analyzed your test data, and your indicators are about the same as before, they are not getting worse or better. In fact, during the tolerability test phase, it was difficult for the study physician and me to judge the efficacy of triazaoctene on patients. All we can do is determine whether the drug is safe or not, what dose the patient can tolerate, and so on. Again, no anomalies are good news. ”

"Hmm...... I know...... I'll stick to it...... Nofi, Nofi is okay? Did Nofi miss me?"