The Nobel Prize recommendation period is from September to January 31 of the following year.

Eligible referees are former Nobel laureates, Nobel Prize committee members, or university professors specially designated by the Nobel Prize Committee.

Most of the winners of the promise who are still alive recommended Shen Qi to select the promise again.

The Nobel Prize Committee also voted for Shen Qi, and Academician Stinga voted anyway.

In the history of the Nobel Prize, there have been people who have refused to accept the Nobel Prize in the field of science.

As a two-time promise winner, Shen Qi prefers to leave the opportunity to others, and his attitude is: "Let it be." ”

On the one hand, Academician Stinga came to persuade Shen Qi to accept the award, and on the other hand, he did come to do academic exchanges.

"I regret that I didn't go to the LHC last year to participate in the great experiment on the information paradox of black holes, but I read the full paper published by Professor Shen on this experiment. The last LHC experiment proved that information does not disappear after entering a black hole. But I have a question, where does the information processed by the wave function go after it enters the black hole, and in what specific form?"

"Carl, do you really want to know?" Shen Qi smiled, calm and mysterious.

"There is a Chinese proverb that says that you can die at night. Yes, I would like to know. ”

"You learn Chinese well, follow me." ”

Shen Qi then showed an unpublished document.

Academician Stinga was stunned after reading it.

"Oh, alas, it's just a deduction model...... If it's true, how good it would be......" Academician Stinga muttered to himself, he really felt that Shen Qi went to receive the Nobel Prize to save face.

Subsequently, Shen Qi arranged for Sha Dongdong to take Academician Stinga to eat hot pot to suppress the shock.

Next, Shen Qi received Academician Alexander Nelson.

Academician Nelson, a medicinal chemist, and his assistants are very interested in the LPJK1 project at the Shen Qi Research Center.

The LPJK1 project is doing animal experiments, and the number of alternative active compounds is decreasing, and when there are still 5 active compounds left, major pharmaceutical companies, including GLK, have inquired about the relevant situation of Shen Qi Scientific Research Center.

Not only pharmaceutical companies, but also some academic institutions are also paying attention to the latest trends in Shen Qi Laboratory. For example, Academician Nelson of the Royal Swedish Academy of Sciences.

"Professor Shen, can we visit your medicinal chemistry experiment?" Academician Nelson asked.

"Of course. Shen Qi led his Swedish friend into the laboratory.

The central chemistry laboratory is currently on semi-vacation, and most of the researchers have gone home for the Chinese New Year, and only Cao Fan, a doctoral student, sticks to his post to clean up.

The active compounds of the LPJK1 project were sent to the Tongzhou Animal Experiment Base for animal experiments, and 22 active compounds were continuously eliminated in the animal experiments, and there are still 5 left.

The laboratory is not as busy as before, and it is quiet and peaceful.

If Academician Nelson and his group proposed to visit the laboratory two months ago, Shen Qi really wouldn't agree.

Now, feel free to visit.

Academician Nelson looked left and right, and said: "Professor Shen, we saw the relevant reports on the 22 macrocyclic compounds synthesized in your laboratory on the patent report, and we were very excited, so we immediately flew to China to have an in-depth exchange with you. ”

When applying for a compound patent, it is usually necessary to attach a general synthesis route, but the patent applicant often does not give a complete synthesis route at the time of the patent application.

Twenty-two compounds in the LPJK1 project of the Shen Qi Research Center have been patented, and like most patent inventors, they have not given a complete synthesis route.

The LPJK1 project innovates some important chemical methods in the process of preparing active compounds.

The 17 compounds that were eliminated caused certain side effects to animals, but these 17 compounds and the remaining 5 compounds were stable in terms of chemical structure and chemical properties.

The twenty-two compounds are all eight-membered heterocyclic compounds, which are macrocyclic compounds

In general, macrocyclic compounds are unstable and can exist in chemical reactions, but it is difficult to obtain stable end products. Because of the instability of macrocyclic compounds, very few organic reactions on macrocyclic compounds have been developed.

This is also the main purpose of Academician Nelson and his delegation's visit: "We all know that the five-membered ring and six-membered ring are the most stable, and most chemically synthesized drugs are also the structure of the five-membered ring and six-membered ring. When it comes to the HIV drug deresinavir, medicinal chemists naturally think of the Paterno-Buchi reaction, or the Aldol reaction, which plays a key role in another synthetic pathway. ”

"Uh-huh. Shen Qi nodded, agreeing with this.

Academician Nelson continued, "In the development of the prostate drug Suertan, Pfizer has designed a number of synthetic routes, each of which has a different core response. In the end, Pfizer chose the synthetic route with the Wittig reaction as the core, because this route has the cheapest raw materials. The drug synthesis of five-membered rings and six-membered rings has formed a very complete set of chemical synthesis systems, and a variety of name reactions have been developed. However, the synthetic route of the eight-membered ring drug and the core reactions involved are almost impossible to find. ”

Shen Qi: "Yes, that's right. ”

Compared with Shen Qi's calmness, Academician Nelson became more and more excited: "Your chemical drug R&D team seems to have given a new idea, and you have obtained 22 stable octa-membered heterocyclic active compounds with the newly developed rearrangement reaction as the core! I would like to know if there is a universal law for the synthesis of stable eight-membered cyclic compounds and even larger cyclic compounds with the new rearrangement reaction as the core?" In other words, can you share the complete synthesis route of the 22 macrocyclic compounds, and the whole set of theories that support this synthesis route?"

"Professor Shen, your synthetic route in the patent report is too simple, isn't it? Now that you have applied for a patent, can you give us a sneak peek and see more complete research results? Or can you publish the latest research results of macrocyclic compounds in professional academic journals as soon as possible? Oh, Professor Shen, in my opinion, your research results can be compared with 'the discovery and development of the diene synthesis method' and the 'development of the olefin metathesis method in organic synthesis'. ”

Academician Nelson spoke generously, and Shen Qi smiled noncommittally.

Cao Fan, a bystander, discovered and developed the diene synthesis method and the olefin metathesis method in organic synthesis...... These research results are all at the level of the Nobel Prize in Chemistry!

But it's not surprising to think about it, Director Shen has made a Nobel Prize-level achievement, which is also a routine operation.