"He Lin, you use chemical equations as a metaphor for life, and if you want to get the target product on the right side of the equal sign, you must sacrifice the original reactant on the left side of the equal sign. On a macro level, this metaphor holds water. ”

"But at the microscopic level, we all know that the number of atoms to the left and right of the equal sign remains the same, the total mass before and after the reaction remains the same, and the same atoms combine to form new molecules under specific conditions. Equivalent exchange is the principle of the permanence of chemical reactions, and if the desired result is not obtained, the process effort of equivalence is not enough. Shen Qi drew a circle on a certain part of He Lin's group's experiment log.

"You just say I'm not doing well. He Lin calmly accepted the leader's criticism.

Shen Qi nodded and said, "It's expected." ”

He Lin smiled dumbly: "It's really direct enough." ”

Shen Qi flipped to the blank page of the experiment log and wrote and drew on it: "How can a new type of chemical drug be in place at one time? As for the next step of your project, my opinion is that the cost of optimizing the lead compound from the high-throughput to obtain the isoindolone intermediate will be about 20%, and the chemical and optical purity will also be increased by about 20%, which is acceptable. The increased cost is within your project budget, so you don't have to add money. ”

He Lin stared intently at the abstract and concrete retrosynthesis route written by Shen Qi, and the target compounds were polycyclic structures, one of which was a large seven-membered ring. There is only one functional group, which is vinyl, at C5.

"This is ......" He Lin's body couldn't help but tremble slightly, from a professional point of view, Director Shen's brain is very vast.

"This is my idea. Shen Qi continued to explain his thinking, "Although compound 7 is a very weak FXa inhibitor, replacing its thiophene fragment with 5-chlorothiophene can theoretically obtain a lead compound with 200 times higher inhibitory activity. Then we not only solve the problem of chemical and optical purity, but also greatly improve the inhibitory activity. I think this should be the LPJK1 receptor blocker that we crave. ”

He Lin fell into deep thought, Director Shen's idea was to disassemble the C2/C3 and C3/C4 bonds, so as to further obtain the eight-membered ring compound on the basis of the seven-membered ring.

In any organic synthesis textbook in the world, there is a rule that in the design of synthetic routes, try to avoid the production of macrocyclic compounds with more than eight yuan (inclusive). Because chemical reactions in this area are rarely developed, the synthesis of macrocyclic compounds is also difficult and unstable.

Shen Qi ignored this iron law, and he suggested that He Lin initiate an exploration of the eight-membered ring compound in the next experiment.

Of course, He Lin has studied macrocyclic compounds, but his research is also very deep, and if he is not a scholar who focuses on theoretical development, few people will spend a lot of energy on such a thankless topic as macrocyclic compounds.

Of course, He Lin also had doubts, she asked: "Director Shen's idea is subversive, I guess Director Shen must have come prepared." The things you wrote on paper are relatively abstract and scattered, and based on the theoretical research of macrocyclic compounds, Director Shen has a systematic guidance document? I would love to learn about it. ”

"It's all here. Shen Qi pointed to his temple and said, "I have been studying macrocyclic compounds for a while, and this LPJK1 project is just right to verify my idea." It must be noted that my idea is not necessarily correct, and I have not fully constructed a theoretical system of self-consistent macrocyclic compounds, and currently only have semi-finished products. I'll send you an email later, and you can check out the attachments in the email. ”

"Wait for your email. He Lin originally wanted to refine their group's experimental design this morning, but Shen Qi's arrival opened a new door for her, and she was very interested in reading Shen Qi's masterpieces that only circulated internally.

"There is a scientific view that people come down to data, life is also algorithms, and the essence of medicine is mathematics. He Lin, your math is OK, right?" asked Shen Qi.

He Lin asked rhetorically: "People who are very bad at math can't read the chemistry articles you wrote?"

"Not really, it's just that it's easier for people who pass math to understand what I'm writing. ”

"When I was studying in England, I read your Riemann conjecture proof. ”

"Do you understand?"

"In order to understand it, I deliberately studied analytic number theory. But I really don't understand your recent mathematical works, about the local model of the unification of mathematics, because there is so much mathematical knowledge to learn, covering almost all branches of mathematics. ”

"You've studied analytic number theory, so you've passed the math, wait for my email, bye-bye." ”

Shen Qi took off his white coat and walked towards the door of the laboratory.

Looking at Shen Qi's back, He Lin suddenly said, "Director Shen, I have a question I want to confirm. ”

Shen Qi turned around and said, "Say." ”

He Lin winked curiously like a little girl: "The code name of the LPJK project is really the abbreviation of 'wife health'?"

Shen Qi asked rhetorically: "He Lin, you have been coming to our center for more than a year, so what do you think LPJK means?"

He Lin replied as a matter of course: "L is Logic, P is Period, J is Joule, which can be understood as energy in a chemical reaction, and K is Kinetics." In my opinion, the meaning of LPJK is that based on the logic of organic synthesis strategy and elemental period, the kinetic analysis and the law of conservation of energy are fully used to obtain a new type of chemical drug. ”

"You're a qualified science and engineering woman, and you've been identified. Shen Qi laughed and said: "But you made up your brain wrong, LPJK is not an abbreviation of English words, but an abbreviation of Chinese pinyin, it really means that my wife is healthy." ”

He Lin was a little moved: "So the legend is true, your wife is not in good health?"

Shen Qi's face suddenly darkened: "My wife is not in good health, she has risen to the height of legends?" This is not a secret, she works in our Yan University, her body is indeed relatively weak, and my friends around me know it." ”

"You have recruited so many returnee doctors, established the LPJK1 research project team, and even broke through the conventional challenge of macrocyclic compounds...... So Director Shen, your ultimate goal is to cure your wife's illness?" He Lin's mood changed significantly.

Shen Qi put away his gloomy look and regained his confident and resolute perseverance: "There are thousands of patients in the world, and my wife is just one of them. Healing and saving people is not just one person, but one type of disease. If we develop a new drug in our lab that can cure that type of patient, including my wife, I will be very grateful for the efforts of all the researchers in our center. ”