There is a diaphragm between the two stomachs of the rat, which causes the rat to be unable to vomit.

In order to ensure the integrity of animal experiments, there are a variety of experimental animals selected, such as cats, dogs, monkeys and other mammals are more sensitive to vomiting reactions and are suitable for vomiting reactions.

Rhesus macaques are widely used in animal experiments, and genetic sequencing studies have shown that 93% of the DNA of humans and rhesus macaques is identical.

The rhesus monkey test group in the cage developed vomiting after taking active compound 2.

Monkeys are intelligent animals, curious and playful.

Some rhesus macaques in the test group sniffed their companions' vomit and had funny expressions.

Compared with severe allergies, liver and kidney failure and even death, vomiting reaction is one of the milder side effects of the drug, and the experimental animals produce a mild vomiting reaction, and the corresponding test compounds are also allowed to pass animal experiments.

"Our active compound 2 has basically no serious side effects in animals, and this compound is considered to be preliminary. He Lin and Cao Fan breathed a sigh of relief.

Animal experiments on LPJK1 continue to advance, and the number of candidate compounds continues to decrease over time.

Half of the twenty-two active compounds were eliminated in a short period of time, and for the remaining eleven active compounds, various tests are still being done on white rats, domestic dogs, rhesus macaques and other animals.

Next is 11 into 10, 10 into 9, 9 into 8...... In the end, Shen Qi didn't need too many compounds left, usually two or three were enough, and no more than 5 at most.

When there were still ten active compounds left, the progress of animal experiments slowed down significantly.

The 10-in-9 test was done for two weeks, and the screening of active compounds became slower and slower the further back on, because the remaining active compounds have undergone so many rounds of testing and have been verified to be safe.

It takes a lot of time to pick the bones inside the egg, but this is something that must be done, Shen Qi They are making medicines, of course, they must be treated with the most rigorous attitude.

When LPJK1 still has 8 active compounds left, the project has already spent more than 150 million yuan.

And this is just the beginning of the burning of money, and the amount of money required to enter the clinical trial phase will increase exponentially.

The LPJK1 project adopts the mainstream mode of combining production, education and research, and after entering the animal experiment, all the funds are borne by OBEQI Pharmaceutical.

In the foreseeable future, OBEQI Pharmaceutical will also invest a large amount of funds to support the clinical trial and marketing approval of the LPJK1 project, which is not only a technical matter, but also involves public relations. All in all, everything costs money.

The weather is getting colder and colder, and the students who have finished the exam are on their way home.

It was Sunday, and there was an intense and orderly cleaning in Academician Shen's villa, and Empress Dowager Ye was about to come here to inspect the work.

Empress Dowager Ye is Ou Ye's mother, a female real estate entrepreneur.

"Nofi, pack up your toys, don't throw them around! If grandma sees it, she will beat your ass!" Shen Qi hurriedly picked up Nofi's various playthings and stuffed them into various drawers.

Shen Nuofei said without pressure: "Grandma won't beat me, grandma will only beat Dad." ”

"You rebel ......" Shen Qi was speechless.

"I thought you were afraid of my dad. Ou Ye laughed and helped Shen Qi pack his things together.

Shen Qi shook his head, saying that he was not at all worthy of Empress Dowager Ye and Lao Ou: "There is no son-in-law in the world who is afraid of his father-in-law and mother-in-law, only a son-in-law who respects his father-in-law and mother-in-law." ”

In the afternoon, the son-in-law, who respected his father-in-law and mother-in-law very much, ushered in the arrival of Empress Dowager Ye.

"Mom!" Ou Ye was so happy.

"Grandma!" Nofi was excited.

"Sister Ye!" Cui Ping was so excited.

"Mom. "Shen Qi is the only man in the family, and he is more stable.

"Little Yezi, Little Nophi, Cui Ping, I miss you. Empress Dowager Ye hugged Ou Ye, hugged Nuofei, and hugged Cuiping.

Then Empress Dowager Ye asked Shen Qi: "How are you doing lately?"

"It's good, it's good, Mom, drink tea. Shen Qi poured tea for his mother-in-law and handed it respectfully.

Empress Dowager Ye drank tea and said to her virtuous son-in-law: "I came to the capital this time, mainly to see your family of three and Cui Ping, and to deal with some business matters in the capital by the way. Nofi and her grandfather will also come in two days, isn't it about the New Year, let's have a reunion dinner in advance. ”

Shen Qi nodded again and again: "Mom is right, just do what Mom says, Mom, drink another cup of tea." ”

"Xiaoqi, you also drink tea, why are you so restrained when you see me?"

"I'm not thirsty, just drink it. Since you are here this time, you and Dad will stay at our house for a few more days. ”

"I think so too, my grandfather and I will stay in the capital until the first day of the new year, and the Chinese New Year's Eve dinner will be eaten in the capital, saving you from running around." ”

Hey, no, I talked to Xiao Yezi that I Chinese New Year's Eve go to my hometown in Nangang for Chinese New Year's Eve dinner this year, and then go back to the north...... Shen Qi smiled on the surface, and in his heart he wondered how to deal with Empress Dowager Ye.

After three rounds of tea, Empress Dowager Ye proposed to let Shen Qi drive her out to do something.

Shen Qi complied, and he drove away from the Yanda area and drove east according to Empress Dowager Ye's instructions.

The two got along alone, and Shen Qi knew that his mother-in-law must have something to tell him.

When the car drove to Jianwai Street, Empress Dowager Ye looked out the window at the embassies of various countries in China, and said with emotion: "Xiaoqi, do you know, I studied French when I was studying, and my dream at that time was to become a diplomat. ”

"Hmm. Shen Qi nodded, his mother-in-law graduated from Beijing Foreign University, and by mistake, China lost an excellent diplomat.

"Diplomat, how high. And the job I am doing now --- building a house is completely different from my original intention. So Xiaoqi, I envy you, your profession is your hobby. ”

"I'm pretty lucky. Shen Qi always has a grateful heart.

Empress Dowager Ye said seemingly inadvertently: "By the way, Xiaoqi, the new material company you invested in is okay?"

"It's ok. Shen Qi said.

A few months ago, Shen Qi took out more than 300 million yuan to invest in Angel Technology Company and became the second largest shareholder of this company.

More than half of the more than 300 million li comes from Ou Ye, Ou Ye can't make so much money, and this money is the pocket money given to Ou Ye by the Empress Dowager Ye.

I gave my daughter's pocket money, Shen Qi, you kid took it to invest in the company...... Among the shareholders of Angel Technology Company, only Shen Qi has no Ou Ye, and Empress Dowager Ye is afraid that she will be held accountable.

In fact, Shen Qi had already thought of an explanation plan, and waited for Mrs. Ye to ask.

"Oh. Who knew that Empress Dowager Ye didn't ask, maybe in her opinion, more than 300 million was just a small amount.

Empress Dowager Ye didn't ask much, and Shen Qi didn't say much, he concentrated on driving and came to the East Fourth Ring Road.