While Shen Qi insisted on exercising, he received the rat experiment report of Obiqi Pharmaceutical on compound C01C.

Animal experimental data showed that in the emaciated rat experiments, when the dose was 1mg/kg and 3mg/kg, the blood drug levels of the rats were 190 nmol/L and 600 nmol/L, respectively, and the inhibition rate of plasma activity reached 69% and 84%, respectively.

The plasma half-life of C01C in rats is 1.7h, the oral bioavailability is 68%, and the clearance rate is 60 ml/(min*kg), and the systematic clearance is mainly through the kidney in the form of an intact maternal drug, and partial clearance can also be achieved through bile excretion and physiological metabolism.

Animal data show that C01C is a compound for the treatment of diabetes if rodents are used as test subjects.

This is in line with reports from Europe, but the Swiss team entered clinical trials and decided that their compound was more suitable for treating Alzheimer's disease.

This is not a contradiction, glycogen synthase kinase-3β is a target associated with a variety of diseases, and based on this conclusion, glycogen synthase kinase-3β inhibitors developed in Europe and China may have different properties.

In fact, the animal experiments of OBEQI Pharmaceutical have just begun, and there are many groups of mouse experiments, as well as monkey and dog experiments.

After the experiments of rats, monkeys and dogs are over, the process team of Obiqi Pharmaceutical and its behind-the-scenes bosses can assert which target the compound C01C is aimed at, and whether it is necessary to enter clinical phase I.

Shen Qi sent a telegram to Nangang: "The results are gratifying, continue to work hard." ”

After shooting the telegram, Shen Qi came to the Yanda Volunteer Service Center and led the team to a nursing home in Shijingshan District.

At last year's joint meeting of the party and government of Yan University, Shen Qi volunteered to take on the responsibility of social service, and he mentioned at the meeting that if the poor are alone, they will help the world, and scholars with profound knowledge should serve the society more widely.

Yan University originally had a variety of volunteer service clubs, most of which were student clubs, but also faculty and staff volunteer associations.

Yan University selected more than a dozen outstanding students from various faculties to form the "Shen Qi Volunteer Service Team", with Shen Qi as the captain.

In the past six months, the "Shen Qi Volunteer Service Team" has carried out many activities, including organizing blood donation, going deep into poor mountainous areas to teach, and serving the disabled.

Today, under the leadership of captain Shen Qi, they went to the nursing home to comfort the elderly and send benefits.

Shen Qi found that there was a new member of the team, she was a new volunteer to join the team, but she had already met Shen Qi and was not a stranger.

"Linna, you're really energetic, you're everywhere. Shen Qi said to the new member Zeng Linna.

Zeng Linna smiled and said, "I have to come to the social service activities in Shijingshan District, because I grew up here. ”

"Are you a child in the compound?" Shen Qi asked, Shijingshan District is a small area on the outskirts of the capital, although this place is small, but it is more distinctive.

"Well, I'm a kid in the compound. Zeng Linna nodded, showing an expression of good memories: "The children in our compound grew up eating hundreds of family meals, usually playing together, and sometimes staying at their friends' houses late in the morning. As for whether the child who broke into the house has good academic performance, whether he can be admitted to a key middle school in the future, and whether he will bring his child badly, parents never care, in their eyes, the child is the child, and he should have the innocence and happiness that the child should have. ”

"It seems that you had a very happy childhood. Shen Qi smiled.

"My best friend in the compound is Duoduo, her parents are busy with work and away from home for a long time, and she was brought up by her grandparents. Grandma Duoduo is very kind, and when she sees that the security guard is wearing thin clothes, Grandma will find thick clothes and quietly hand them to the security guard. When I met a beggar on the side of the road, the old lady would ask me and me to buy a few more steamed buns and a bowl of porridge and send them over. The old lady was full of love for everyone, and she believed that if everyone gave a little love, the world would be a better place. Zeng Linna recounted her childhood, which was spent in a healthy and harmonious environment.

"What an old lady full of positive energy, she must live a long and healthy life. Shen Qi listened with great interest.

"Grandma is 80 years old this year...... Zeng Linna said, and suddenly, she was smiling and became sad: "Grandma lives in this old people's home now, and her house is only a mile away from here. ”

"......" Shen Qi was silent for a moment, and then asked, "What about grandma's children, and what about your best friend's parents?"

"My best friend's parents are still busy, my grandmother has three sons and a daughter, but she now lives in a nursing home, her wife is gone, and she is alone and alone. Zeng Linna became more and more melancholy.

"Go, take me to see this old lady. Shen Qi sighed, this is quite ironic, the old lady who has done good deeds, cared for others, and spread positive energy all her life is now unable to enjoy the care of her children.

"No matter what, I prefer to believe that there is more love than hate in the world, and that good people will be rewarded in the end. So I joined the volunteer association, and I wanted to do what I could for people in need. "The aura of the Virgin on Zeng Linna's body shines brightly, the environment in which she grew up, and the things she has experienced, make her a little different.

"That's right, good will be rewarded, maybe the time has not come. Shen Qi and Zeng Linna came to an old lady.

The old lady sat quietly on the chair, and on a hot day, she was wrapped in a thick autumn dress, her face was like a statue, and she was wrinkled and expressionless.

The arrival of Shen Qi and Zeng Linna did not cause the old lady's mood to fluctuate at all, she just sat still, motionless, and silent.

Zeng Linna knelt down on one knee in front of the old lady and said softly, "Grandma, I've come to see you." ”

The old lady glanced at Zeng Linna, and finally spoke: "Yulan, this winter is cold, your body is weak, pay attention to keeping warm." ”

Zeng Linna's eyes moistened instantly, and she murmured: "Grandma, it's me, I'm Nana, Nana from Zeng's bald family......"

Old lady: "Xiao Li gave me a painting yesterday, which is a portrait of the chairman and his old man, and the painting is very good." ”

Zeng Linna's tears flowed out, and Xiao Li in the old lady's mouth had been dead for five or six years.

Confusion in memory, inconsistencies in the preamble...... Shen Qi observed for a long time, and he could roughly judge that the old lady was suffering from Alzheimer's disease.

Alzheimer's disease, also known as Alzheimer's disease, has increased dramatically in the world, and the number of people suffering from this disease has also risen dramatically, spreading to all corners of the world.

Alzheimer's disease and other types of dementia are not part of normal aging, the number of elderly people in China has reached 300 million, and the number of Alzheimer's disease patients is huge.

Although scientists have discovered how Alzheimer's disease is causative, there is still a long way to go before finding a cure for the disease.

Pharmaceutical giants Johnson & Johnson, Pfizer, Eli Lilly and other companies have invested heavily in the research and development of Alzheimer's drugs, but they have fallen short.

Roche's hundreds of millions of dollars anti-Alzheimer's drug gantenerumab failed in a phase III clinical trial, the closest attempt to success to date, but it failed.

The high hopes are now high for the Swiss Novartis R&D team, which completed a European phase II clinical trial of an Alzheimer's disease drug three years ago, but the results of subsequent tests are unknown and have not been publicly reported.

The research and development of Alzheimer's drugs has become a huge pit, a bottomless black hole.

Zeng Linna sobbed, and the old lady was indifferent.

Shen Qi saw it in his eyes, but it was not a taste in his heart.

Shen Qi didn't know if his C01C could succeed, he was very eager to succeed.

Whether it is Alzheimer's disease, diabetes, or immune disease, as long as C01C can cure one of these diseases, Shen Qi can be satisfied.