"Director Shen, only from the chemical level, C01C-2 is successful. "Lao Yan is still very excited, after all, there are a lot of innovations in this project.

"To synthesize a new compound, three points depend on experience, three points depend on technique, and the rest is a matter of luck. I'm lucky. Shen Qi asked Lao Yan and Cheng Haonan to do a few more sets of experiments, and then sorted out a report.

C01C is a benzothiazinone compound that can theoretically treat diabetes and has been validated in rat experiments.

Because the effect was not satisfactory in the dog experiment, Shen Qi improved the chemical structure of C01C, C01C-2 still uses benzothiazinone as the parent nucleus, and the side chain has been optimized.

According to Shen Qi's research, C01C-2 is also a compound for the treatment of type II diabetes, and it will be verified in animal experiments.

Diabetes is widely recognized as the world's most widespread epidemic, with 200 million people worldwide suffering from the disease today and the number expected to double within a decade.

Type II diabetes is a chronic polysaccharide condition accompanied by insulin antibodies, which prevent the pancreas from producing enough insulin to control blood sugar levels.

Many of today's treatments for type II diabetes are not as effective as they could have been due to their side effects.

Therefore, Shen Qi believes that their research result C01C-2 has very important scientific research value.

At the level of mechanism theory, there is still a puzzle that plagues Shen Qi.

C01C-2 can be classified as a non-ATP-competitive inhibitor of glycogen synthase kinase-3β, in which glycogen synthase kinase-3β is a multifunctional protein kinase and a target associated with a variety of diseases, such as diabetes, Alzheimer's disease, cancer, immune diseases, etc.

Why did Shen Qi and the C01C-2 they synthesized mainly target diabetes rather than other diseases?

How to pinpoint the target, and what kind of disease do researchers want to make corresponding inhibitors?

This requires ongoing research to find the true control mechanism.

Ouye did not suffer from diabetes, and what plagued her for a long time was immune disease and anemia.

Recently, Ouye's body has not been very well again, she is tired and lacking in energy. Shen Qi saw it in his eyes, and his heart was anxious.

"Anyway, let's finish the clinical trial of C01C-2 first. Shen Qi is determined to complete the follow-up testing of C01C-2, although C01C-2 is set as a type II diabetes drug, Shen Qi believes that in the process of in-depth research on it, there is hope to find the true control mechanism of glycogen synthase kinase-3β, and accumulate valuable experience and data for the next compound against the immune disease of Ouye.

The paper of C01C-2 is entitled "Design, Synthesis and Biological Activity Evaluation of Benzothiazinone Glycogen Synthase Kinase-3β Non-ATP-Competitive Inhibitors", which was published in the Journal of the American Chemical Society, an internationally renowned chemical journal.

As mentioned in the paper, our research group designed a synthetic route through a new molecular hybridization method, obtained novel benzothiazinones, and studied their inhibitory activity and kinetic mode of action against glycogen synthase kinase-3β. Studies have shown that this compound has a certain reference value for the treatment of type II diabetes.

The American Chemical Society is very concerned about the research results of Shen Qi's chemistry research group, and they said that the paper talks about a new synthetic reaction, which has important academic value.

"Professor Shen, we hope that you will come to the United States, and we will organize a high-end academic seminar for you. The president of the American Chemical Society sincerely invited Shen Qi to the United States for academic exchanges.

Shen Qi said on the phone: "After the time is confirmed, I will contact you again." ”

In addition to the American Chemical Society, the institutions that invited Shen Qi to the United States include the American Mathematical Society, the American Physical Society, the American Academy of Sciences, Princeton University, Harvard University, and the California Institute of Technology.

Shen Qi left the United States for five years and did not go to the United States during that time.

This time Shen Qi changed his mind, and he decided to go to the United States.

Princeton is where Shen Qi once studied and worked, and he still holds the title of honorary professor of mathematics at Princeton, and it is not appropriate to refuse friendly invitations from his alma mater one after another.

The American Academy of Sciences awarded Shen Qi the title of Foreign Academician, and Shen Qi accepted the title, and he still had to go to the United States to collect the certificate if he was free.

In the field of chemistry, Shen Qi has ideas.

The system is set to upgrade from level 12 to level 13 in chemistry, and Shen Qi must win at least one international chemistry award and 4 million academic points.

Won the Nobel Prize for the second time, was awarded to foreign academicians in the United Kingdom, the United States, France, Russia and other countries, and became a double academician in China, this series of achievements brought Shen Qi tens of millions of academic points, and he now does not lack academic points, only lacks the special conditions set by the system.

With a new organic reaction, it may be difficult to win the Nobel Prize in Chemistry.

If Shen Qi's C01C-2 successfully passes several phases of clinical trials and is verified to be the best diabetes drug to date, then he has a chance to obtain Nuohua.

Or, if Shen Qi finds the true mechanism of glycogen synthase kinase-3β inhibitors and can establish a set of mechanism system theories for precise targets, then he has a higher probability of winning the Nobel Prize in Chemistry or the Prize in Physiology and Medicine.

This is not an overnight effort, after all, chemistry is only level 12.

Shen Qi brushed almost all the awards that could be brushed in the mathematics and physics circles, and he brushed them repeatedly, and he brushed them twice.

Now, it's time to brush up on the chemistry awards.

The American Chemical Society has several international chemistry awards, and Shen Qi has some thoughts about this, but he can't be too straightforward, after all, he is a famous scientist with status and status.

"Leader, I want to go to the United States for academic exchanges, please approve it. Shen Qi reported to the central government, and the central government supported any country he went, except for the United States.

Leader: "The spokesperson of the Ministry of Foreign Affairs of our country has expressed his views at regular press briefings many times, we are not targeting the United States alone, we expect the United States to get back on track, and we also believe that the United States can get better and better under the leadership of the new leadership team. But Professor Shen, do you have to go to the United States in person?"

"Leader, there's no way, I have some academic friends in the United States, I have to go and see them, they are all eighty or ninety years old, and if I don't watch them, I won't have a chance. Shen Qi was telling the truth, one of his friends in Princeton hung up not long ago, and two of them were dying on the hospital bed: "These American academic giants have given me a lot of academic guidance and help, putting aside political differences, I should go to the United States to visit the old-timers, visit my teachers and friends." ”

"Respecting teachers and valuing education is a virtue, and Professor Shen is right to do so. After careful consideration, the leaders agreed that Shen Qi would go to the United States for a friendly academic visit.

"You'd better not go to the U.S. alone. "The leader makes a proposal.

"Okay, I originally wanted to take a team to the United States. Shen Qi said, and immediately began to organize his academic exchange team to the United States.