Laboratory 401.

Shen Qi took some samples and showed them to Lao Yan: "This is what I synthesized, theoretically it is a drug for the treatment of immune diseases, after analysis, the composition is the same as Leloxinfine, but the drug safety, toxicology, and drug metabolism need to be further verified through animal experiments." ”

"Can you see your route?" asked Lao Yan.

"Wow. Shen Qi spread out a piece of paper, on which was drawn the road map of Le Luo Xianfen.

The design of an effective synthetic route for complex organic molecules is one of the most difficult problems in organic chemistry, and route design is the first and most important step in the synthesis work.

In English materials, terms such as strategy and art can often be seen in the description of organic synthesis route design, and organic synthesis route design has risen to the level of strategy and art.

The strategic route of Shen Qi's version of Leloxine starts from the reaction between paraben and amine, and ends with the metal-catalyzed coupling method to obtain Leloxine with a large stereo hindrance, with a total yield of 43% and a total of 30 steps.

Lao Yan concentrated on studying Shen Qi's route design, and couldn't help but exclaim: "The 30-step route can get a total yield of 43%, which is very good." ”

Shen Qi was a little regretful: "Indeed, there are too many routes, if it can be controlled within 20 steps, the total yield will be even more impressive." But there is no way, I am a copycat version of Le Luoxianfen, and it is impossible to be exactly the same as the original Eli Lilly Company in terms of strategic route, I believe that their route design must be more concise and the total yield will be higher. ”

The design of the strategic route of organic synthesis is different from mathematics and physical calculation, which have fixed formulas and theorems, while organic synthesis is more flexible.

Any synthetic route, as long as the required compounds can be synthesized, should be said to be reasonable.

But there is a big difference between the reasonable synthetic routes. Some synthetic routes have higher yields for each step, but the total yield is less than 1% because there are too many steps.

"Boss Shen, what do you need me to do?" Lao Yan habitually touched his pockets, and his cigarettes were in his pockets.

Shen Qi reminded: "Hey, the addiction to smoking is done again? It's been less than 30 minutes." Can you restrain yourself, you do chemistry, and smoking in the lab is dangerous, don't you know?"

"As soon as I got into academic mode, I wanted to smoke. "Lao Yan still has professional ethics, he just touches the cigarette case and doesn't take it out.

"Condochren, have you heard of it?" Shen Qi took out a bottle of medicine.

Lao Yan took the medicine bottle, opened the lid to look at the medicine inside, and looked at the instructions: "Condochren, a Swiss medicine for anemia, this medicine is quite expensive." ”

Shen Qi explained the task: "This imported medicine costs 12,000 yuan a bottle, old cigarettes, synthesize it." ”

Lao Yan was surprised: "Boss, are you teasing me?"

Shen Qi said seriously: "Do you think I'm joking?"

"Are you going to open a fake medicine factory?" Lao Yan thought that he had been cheated into a black store.

Shen Qi explained: "First, we only forward synthesis after reverse analysis, experimental nature, no pharmaceutical factory and no sales. Second, what we synthesize is not a counterfeit drug, at most it is a generic drug, which will not enter the market and will only be used for scientific research. ”

"Reverse analysis followed by forward synthesis, imitation of extremely complex drugs, almost challenging the limits of my academic ability. Lao Yan rubbed his hands solemnly and said, "But for the establishment of the central smoking area, I accept this challenge." ”

"Okay, if you encounter any problems during the synthesis process, you can communicate with me. Shen Qi finished arranging Lao Yan's task, and then went to the animal laboratory next door.

Before Lao Yan came to the center, Shen Qi had already studied his past academic achievements, personal experience and other detailed information.

Lao Yan's undergraduate and graduate students both studied at Yan University Chemical Institute, and went to Stanford for a year of exchange.

Although he did not study for a PhD, Lao Yan's laboratory experience was sufficient.

To Shen Qi's surprise, Lao Yan graduated with a master's degree at the age of 24 and is 28 years old this year, and he has published as many as 15 chemical papers in four years, but he does not own a single chemical patent.

Many of the papers written by Lao Yan are imaginative, and his wishes are grand but difficult to land.

Shen Qi felt that Lao Yan was not a master of Lao Yanyan, Lao Yan was a person with ideas, imagination, and a little skin, and his character could be seen from Lao Yan's self-made hand-guarding friction cigarette lighting materials.

Organic synthesis has achieved a certain height, it doesn't matter if Dr. Ph.D. is not a doctor, this experimental discipline relies on imagination, observation, and logical derivation. Shen Qi thought that Lao Yan had these potentials, so he asked him to be such a person.

"But this guy Lao Yan, the addiction to smoking is really too heavy. Shen Qi spit out, the information of the old cigarette at the beginning wrote "good health, no bad habits", two packs of cigarettes a day, is this still healthy?

Lao Tu, the manager of the animal laboratory, said: "Many of the people who do scientific research, men, smoke. I have been at Yan University for 20 years, and most of the science and engineering men I have come into contact with are not good at socializing, and they don't have time to socialize, because it takes time to study science. But people always need to relax, drinking and hurting things, and drinking a big drink also takes time, so there are many smokers, and it is good to smoke for a few minutes, and continue to study science after drinking. ”

"I understand that, but I still advocate a healthy lifestyle and cultivate other hobbies for researchers. Most of the scientific researchers Shen Qi came into contact with were in this situation, their social circles were small, and their social relations were basically colleagues and peers in their own small circles around them, in addition to their parents and relatives.

Scientific research workers who concentrate on learning and doing projects do not have much time to party, go shopping, and go to the waves, and their life trajectory is relatively monotonous, home-laboratory-home.

"Come on, old Tu. Shen Qi chatted with Lao Tu for a few words, and this entered the topic.

The theme is to inject two female monkeys, Xiaohong and Xiaomei, with Le Luofen.

After the animal was anesthetized, the experimental drug was injected, this was the basic exercise, Shen Qi and Lao Tu joined forces, and it was quickly done.

Next, Shen Qi needs to regularly conduct toxicology, pharmacokinetics, and drug metabolism tests on Xiaohong and Xiaomei, a process that will last several months, during which several female mouse subjects will be supplemented to obtain more sufficient experimental data.

At five o'clock, Shen Qi drove to the courtyard to pick up Ou Ye and go home.

Ou Ye suddenly said: "Show me the 1017 baby names you think." ”

Shen Qi: "In the glove box." ”

Ou Ye opened the glove box with great interest, saw a notebook, took it out and flipped through it.

When a woman is three to four months pregnant, the sex of the fetus can be determined by ultrasound.

The state does not allow non-medically necessary fetal sex determination, but the Shen Qi couple must have a way to know the sex of the fetus in advance, if they want to.

However, Shen Qi and Ou Ye decided to leave the suspense until the time of delivery in August, and they did not know the sex information of the fetus in advance.

Looking at the list of baby names compiled by Shen Qi, Ou Ye was speechless.

The book reads:

Boys, Shen Differential, Shen Integral, Shen Number Theory, Shen Fraction, Shen Complex Variant, Shen Variable Fraction......

Girl, Shen Quantum, Shen Atom, Shen Proton, Shen Neutron, Shen Ion, Shen Soliton......

The baby naming rules written by Shen Qi, Ou Ye fully understood, that is, copy it according to the math book and physics book, no wonder he can copy 1017 professional terms.

Although he understood, Ouye couldn't accept it.

"Shen Qi, can you be serious!!" Ou Ye roared, very emotional, and used three exclamation points in a row.

"Wife, I'm serious!!!" Shen Qi used four exclamation points, he wasn't joking, this was what he really thought in his heart.

"Shen Qi, your uncle!" Ou Ye angrily slammed the dashboard, she angrily scolded Shen Qi: "People are cheating fathers, Shen scientists, you are cheating babies!"

Shen Qi was still aggrieved: "Why did I cheat the baby? The name I chose for the baby is not good, too cheesy, or is the realm too low?"

"My colleague in the office next door gave birth to a boy named Liu Haoxuan. Downstairs in our house, the baby girl is called Zhang Zixuan. Ou Ye quoted an actual case, and she said: "Husband, can we take the name of our baby a little more mainstream?" Haoxuan and Zixuan are quite good. ”

Shen Qi has his theoretical basis: "Wife, you must believe in my professionalism and forward-looking vision, I have done mathematical statistics, the Haoxuan and Zixuan you said are the names that appear most frequently in newborns now, Haoxuan ranks first in male BB, and Zixuan is first in female BB." Hao Xuan and Zi Xuan sound good now, but after a few years, the streets will be full of Uncle Hao Xuan and Aunt Zi Xuan, which are not distinctive. ”

Think about it, the frequency of Haoxuan and Zixuan is indeed too high, and a few years later, it may be Haoxuan's children 01~08 and Zixuan's children 01~18 in the kindergarten, and the children's parents are easy to recognize. Ou Ye was still insisting, but he was a little loose: "Then you use the branch of mathematics, or the name of the physical noun, and you have characteristics?"

"It does have character, but ...... Is it good to be super non-mainstream!" Ou Ye was speechless, if her child was called Shen Shulun, Shen Integral or something, and when he grew up, he could become a scholar in the past, in case he was a scumbag, it would be very embarrassing.

Shen Qi asked: "Wife, if you had to choose one of my names list, what would you choose? Of course, as the mother of the child, you have the right to overturn all my plans." Shen Haoxuan and Shen Zixuan also sound good, if you adhere to the mainstreaming and popularization plan of Haoxuan and Zixuan, I will respect your choice. ”