Yanda Stadium, the whole school sports meeting kicked off.

Shen Qi wore sportswear and running shoes to participate in the men's 100-meter preliminaries of the student group.

Bang! Gunshots rang out, and the game began.

Eight runners set off.

Shen Qi, who was in lane 2, had a mediocre future and a strong back, and he won the first place in the group with a time of 10.99 seconds and advanced to the semifinals.

The men's 100-meter semi-final of the student group was held in the evening, and many spectators came to the scene, most of them were students, but also the faculty and staff of Yan University.

There are two groups of semi-finals, with a total of 16 players, and the competition system is that the top two players in each group directly advance to the finals, and the remaining players compare their results, and the four players with the best results will qualify for the finals.

The top two runners in the first group of the semi-finals were 10.75 seconds and 10.81 seconds, and the fifth place runner in this group ran 10.93 seconds, which means that five college athletes in this group have reached the standard of first-class sprinters.

The five contestants are all sports special students, the youngest is a freshman and the oldest is a senior.

To enter the Yanda track and field team, a first-class athlete is the basic requirement.

The Yanda track and field team has several athletes, as well as an international athlete.

The fastest male athlete on the Yanda track and field team this year is an athlete, who is a junior in law school and is in the second group of the semifinals.

Shen Qi is also in the second group, and the athletes of the law school are on the track next door to Shen Qi.

The athletes were very surprised that the famous Professor Shen actually entered the semifinals.

"This athlete classmate, I heard that you are the fastest man in Yan Da, what is the PB?" said Shen Qi to the athlete next to him.

Athletic: "10.43 seconds." ”

Shen Qi asked: "That's very powerful, you can enter the national team, right?"

The athlete shook his head: "Professor Shen, times have changed, and the national 100-meter record has reached the level of 9.90 seconds. Now to enter the national team, you have to run at least 10.25 seconds. ”

"Everyone's in place!" the starter shouted.

The athletes stopped talking and got ready for the start.

Bang!

At the beginning of the race, Shen Qi started quickly, and he ran 50 meters at the fastest start, and found that he had fallen to sixth.

"These college students are really strong!" Shen Qi didn't know if he didn't run, he was startled when he ran, the second group was the group of death.

In the last 20 meters, Shen Qi risked his life to increase his stride, overtook two people, and won the fourth place in the group with a time of 10.79 seconds, and after comparing the results with the first group, Shen Qi advanced to the 100-meter final.

The competition adopts the electrometer mode, an anemometer is installed in the venue, and the final list of the men's 100 meters in the student group is displayed on the big screen.

Shen Qi's qualifying time was fifth among all competitors, and he ran a good time of 10.79 seconds with a tailwind of 0.5m/s.

One professor was able to finish fifth in the student group and ran under 10.80 seconds, which surprised many viewers.

Shen Qi looked at the big screen, he was still quite excited: "10 seconds 79, PB!"

Shen Qi's mentality was to enjoy the race, and he ran the fastest 100-meter run in his life.

Only after running can you deeply understand why the once 10-second mark is considered the limit of the yellow race, and it is really too difficult to run into 10 seconds.

The other student runners gathered around Shen Qi and were all surprised: "Professor Shen, your sprinting level is really professional!"

"Come on, boys, I'm not going to show mercy in the final. Shen Qi laughed and left the scene.

Today's two-shot 100-meter run was hearty, and Shen Qi found the coach of the track and field team and said that he wanted to get a first-class athlete certificate.

The coach said that there was no problem, 10.79 seconds had exceeded the first-class athlete standard line, and this time, experts from the Chinese Athletics Association were also invited to assist in the all-school sports meeting of Yan University, and the competition specifications met the application conditions of first-class athletes.

The 100-meter final is scheduled for the following evening.

On the morning of the 100-meter final, Shen Qi participated in the men's long jump preliminaries of the student group, and he jumped over the 7-meter passing line in his first jump and advanced to the long jump final.

After the jump, Shen Qi returned to the center to deal with related work.

Participating in sports competitions and competing with young people, Shen Qi felt that he had become younger and full of passion.

Passion ripples and inspiration flows.

"By the way, I thought about it. Shen Qi had imagined a new target compound that he hadn't come up with for a long time, but at this moment he had a new idea.

"With benzothiazinone as the parent nucleus, the hydrophobic side chain of the n-dodecyl group is introduced, yes, that's it. ”

Shen Qi drew the imaginary target molecule on the paper, and then began to work backwards.

The properties of organic compounds are mainly determined by the functional groups in the molecule, and the functional groups are attached to the molecular skeleton, and if the skeleton cannot be established, the functional groups have no home.

The synthesis of complex molecules contains changes in the molecular backbone from small to large, and the large backbone of the target molecule is synthesized step by step from the small backbone in the previous reactions.

Shen Qi began to disassemble the target molecule, which required professional skills, derivation ability, and familiarity with various organic reactions.

The selection of the molecular disassembly site is appropriate and plays a decisive role in the success or failure of the synthesis.

Shen Qi carefully took out an acylhydrazide compound, as for the acidic or alkaline conditions, how much temperature, and what catalyst the hydrazide compound synthesized to obtain the target product, there is no need to consider it now.

In the route design stage, there is no need to consider too many restrictions on reaction conditions, otherwise chemists will never be able to design a synthetic route.

As for why he designed the target molecule of benzothiazinone parent nucleus + hydrophobic side chain, first, Shen Qi found this molecular structure interesting, and second, he had previously studied relevant literature.

This target product could theoretically be a glycogen synthase kinase-3β inhibitor.

Glycogen synthase kinase-3β is a multifunctional serine/threonine protein kinase present in mammals, which is involved in the regulation of a variety of physiological processes in vivo and affects a series of cellular functions through phosphating, including metabolism, differentiation, proliferation, apoptosis, etc.

It has been reported in Europe that glycogen synthase kinase-3β inhibitors can be used to treat Alzheimer's disease, and a certain compound has been used in phase IIB clinical trials in Europe.

In the United States, it has been reported that glycogen synthase kinase-3β inhibitors can be used to treat diabetes.

Japan reports that glycogen synthase kinase-3β inhibitors can be used to treat immune diseases.

Glycogen synthase kinase-3β is widely distributed in the human body, this kinase tube is very wide, the central nervous system, metabolic system, immune system, everywhere can see it, it is a target of a variety of diseases.

This is also the reason why Shen Qi chose benzothiazinone as the parent nucleus + hydrophobic side chain as the target molecule.

"One step backwards to come out......"

Shen Qi has been pushing until the afternoon, looking at the time, he has to go to the sports field to warm up.

Shen Qi did not have any psychological burden in the one-shot 100-meter final in the evening, enjoyed the passion and enjoyed the competition.