If he has the opportunity, Shen Qi wants to join the scientific expedition team, and there are four places he wants to go to the most, the South Pole, the North Pole, the equator, and Mount Everest.

From the perspective of geophysics, the polar regions and the equator are very special zones, and various natural data of the polar regions and the equator have a whole impact on the world. Mount Everest is the top of the world, and the data collected there is of great scientific importance.

Going to these four places and collecting ideal data is Shen Qi's medium and long-term plan, and it is what he wants to do.

This was done in order to verify one of Shen Qi's ultimate conjectures.

Shen Qi's physical exercise continues every day, and scientific research is a very physically demanding work, and in special situations, he also needs to have good explosiveness and flexible body reactions.

Project 0 of the Central Chemistry Laboratory has been advancing for some time, and Lao Yan and Cheng Haonan have optimized the experimental procedures and synthesized preliminary samples according to the route designed by Shen Qi.

However, the total yield of the sample was only 2%, which was clearly not up to the mark.

2% is at least multiplied by 0 times to be a valuable scientific research achievement.

Shen Qi changed into a lab coat, entered the chemistry laboratory, and worked with Lao Yan and Cheng Haonan to study the topic of improving the 0 yield.

"Project 0, the ninth benzothiazinone experiment. The old cigarette read it in his mouth, and wrote it on the experiment log.

The main operator is Cheng Haonan, who has super hands-on ability, he takes 5g of benzothiazinone and 25g of potassium carbonate as starting materials, dissolves them in 250L DF, adds halogenates in the stirring state, and stirs for 3h.

Stirring is carried out in a blender while TL monitoring.

TL stands for thin layer chromatography, in which a suitable stationary phase is applied to a silica gel plate for drug identification, impurity detection or content determination, and tracking the reaction process.

Shen Qi set the route, and Lao Yan and Cheng Haonan set the drug dosage, specific experimental methods, and operation/monitoring/testing details.

The synthesis of a target compound, from route design to sample delivery, is a comprehensive work that requires a team to complete.

The design of the organic synthesis route examines the strategic pattern and profound chemical knowledge reserve of chemists, and the specific operation tests the patience, carefulness and sense of responsibility of the experimental apes.

There is an essential difference between a chemical ape and a chemist, a chemist may be short-tempered and informal, and an experimental ape is cautious and meticulous in every way.

In the end, it is the chemist who will be remembered by the world, and he may only be a lifelong operator who is cautious and cautious.

It's not that patience, carefulness, and responsibility are shortcomings, on the contrary, they are the shining points in human nature.

A careful, patient and responsible chemical laboratory ape, with a little bit of ambition and strategic height, may be promoted to a chemist.

Of course, ambition and strategic heights need to be accumulated over time, and a little bit of chance.

Lao Yan, who has been working in Yanda, has no ambitions, and his biggest wish is to smoke the top cigarettes every day, in unlimited quantities.

Cheng Haonan's ambition has been completely consumed in more than five years of organic migrant work, and compared with the real life and survival, the ambition is too far away.

It was Shen Qi who inspired Lao Yan and Cheng Haonan's buried ambitions in their hearts, and the patent of 0b was sold for more than one million, Shen Qi divided it by three, and the three were divided equally.

Material giving is the most primitive means of driving one's ambitions.

Although raw, there's no denying that it works.

A more advanced way than material drive, is honor.

If the desire for material and honor is satisfied, a person will only be left with ideals.

Before the ideal is realized, it often exists in the form of conjecture.

The agitator is stirring, TL is monitoring in real time, and this process will last for 3 hours.

Within 3 hours, at least one person must stay in the laboratory to follow up the progress of the experiment and ensure the safety of the laboratory.

Therefore, it is normal for scientific research workers and experimental apes to go out to surf, to sisters, to ditch boys, and to socialize. Scientific research is very time-consuming and energy-consuming, and the industry is diligent and frolic.

Shen Qi accompanied Lao Yan and Cheng Haonan in the laboratory for three hours, and everyone discussed how to improve the total yield.

At this point, TL monitors that the raw material reaction is complete, and the next operation is to leave it overnight at room temperature.

The experimental drugs were overnight, and the experimental apes also had to stay overnight, and Shen Qi and the three of them went back to their respective homes and spent the night with their respective women. Nothing was said all night.

Early the next morning, the three of them came to the laboratory, this time to change Shen Qi's main operation, and he also had to practice practical skills from time to time.

Shen Qi added an equal volume of water to the intermediate product that was placed overnight, extracted it with ethyl acetate, combined the organic layer, washed three times with saturated salt water, dried with anhydrous sodium sulfate, and separated by silica gel column chromatography to obtain a yellowing crystal compound 2.

"Director Shen's practical skills are very skilled. Cheng Haonan praised.

"When you two are away, I have a good time practicing secretly. Shen Qi said, picked up the previous experimental record and looked at it: "In the previous experiment, the yield of compound 2 was 78% to 82%, which is a beautiful data. ”

"All the way up to compound 4, the data is beautiful, and the problem is at steps 4 to 5. "Lao Yan began to operate the next step, under the protection of nitrogen, stirring compound 2, sodium hydride, and DF in a water bath.

It can be clearly seen that the reaction solution changes from a slightly disgusting yellowish to a delicate rose red.

After adding d, the first step of extraction, washing, drying, silica gel column chromatography separation and other steps was repeated, and oily compound 3 was obtained with a yield of 8%.

The operation of 3 to 4 is to dissolve compound 3 in methanol, add hydrazine hydrate, and leave it overnight.

The three of them went back to their respective homes again and spent the night with their respective women. Another night without words.

The next morning, the central chemistry trio obtained compound 4 with a yield of 55%.

Two days and two nights of experiments have been carried out so far, and the data is beautiful.

"From 4 to 5, the yield drops sharply from 55% to 2%, which is a big problem. Shen Qi has been doing a review for the past two days, and has come up with a new plan: "We have changed the path and replaced part of the hydrophobic side chain with hydrophobic aromatic heterocycles. Start work, the old Cheng is the main operation, the old smoke is assisted, I will see if I don't speak. ”

"Is it really appropriate to replace part of the hydrophobic side chain with hydrophobic aromatic heterocycles?" Lao Yan was a little puzzled, but Cheng Haonan had no opinion at all.

In fact, Shen Qi appreciated Lao Yan's skeptical spirit more, he said: "Experiments are not like this, keep trying, keep doing, do to know, which one is more suitable for you, which one is destined to be just a passerby in your life." ”

"Practice makes sense. Lao Yan smiled and said no more.

Under the guidance of the new idea, the trio dissolved carboxylic acid in acetonitrile, added HBT and stirred for 5 minutes, then added EDI and compound 4 overnight at room temperature.

The organic experiments were conducted around the clock, and in the early morning after the third night, the trio finally obtained a target product with a total yield of 25% through a series of purification operations.

After testing, it was found that the physicochemical constants and spectral data of the target product were very k.

The structural formula coded 0 is benzothiazinone benzocyclophenyl ring H3(H2)9H2, and the interesting feature of the structure of this compound is the design of long hydrophobic side chains.

Shen Qi and his team designed the molecular structure of the target and prepared the sample through the established route.

“25%！”

"It worked!"

"Another new compound is born!"

The most attractive part of chemistry is the creation of new substances, Shen Qi, Cheng Haonan, and Lao Yan high-fived and celebrated, showing excitement.