"Interaction is necessary. Lao Yan said absent-mindedly.

Shen Qi spread his hands and said, "Come on, I don't care about feelings, you can do it yourself." ”

Cheng Haonan asked, "Director Shen, the purification of C01B is complete, what will you do next?"

For example, the secretion of dopamine in the nucleus accumbens region of the limbic dopamine system is the most basic mechanism of nicotine addiction, through which the physiological effects of nicotine absorbed during tobacco use create a strong sense of pleasure, which in turn leads to dependence.

Based on this mechanism, the R&D teams of scientific research institutions or pharmaceutical companies have begun to develop compounds, for example, American scientists have synthesized a new compound in the laboratory by taking the nicotine receptor part of neurons as the primary target of nicotine activity.

At this point, the prototype of smoking cessation drugs has been produced, but it does not yet have the conditions to be marketed.

The rest is done by pharmaceutical companies, who optimize the compound, complete various tests according to the regulations, and then register, sell. The above-mentioned compounds were commercialized by Pfizer in the United States and successfully registered in the FDA under the trade name Bingshi and were marketed.

In terms of forced grid, it must be the highest mechanism research, followed by the first synthesis of compounds in the laboratory. The Nobel Prize-winning scientists are mainly from these fields of research.

It is impossible to win an award for mass production of drugs, and then register and sell them, but they can make money.

The basic mechanism of nicotine addiction has been studied.

Shen Qi and the others have now achieved the second step, synthesizing a new compound with smoking cessation effect for the first time in the laboratory, and the internal code name is C01B.

Pfizer is a pharmaceutical giant, and they produce the famous aphrodisiac Viagra.

Shen Qi's C01B and Pfizer's Ring Bishi are better than each other, it is impossible to judge now, and they need to be tested.

Who does the test?

Anyway, Shen Qi and the three of them don't do it.

So what to do next, Shen Qi's suggestion is: "C01B has achieved this step, and the patent has been generated, if any pharmaceutical company is interested in this patent, we will sell it to whom." ”

"Isn't this generic?" asked Lao Yan.

Shen Qi said: "It can't be regarded as a generic drug, based on the same mechanism, our synthetic route and final product are different from those of the Americans." For us, the work on C01B is over. We can start the next project. ”

As for what to do in the next chemical project, Shen Qi said that it must still be organic synthesis, and the two of them also think more about TM, and the principle is to have a certain degree of innovation.

Retrosynthesis is the most basic method of organic synthesis route design, in which chemists first conceive a target molecule (TM) and design the synthetic route in the opposite direction.

Starting from TM, step by step, we first consider which intermediates can be synthesized TM, and then consider which raw materials can be used to synthesize intermediates, and the final raw material is the starting material.

There are three basic principles, first, there is a suitable and reasonable reaction mechanism and synthesis method for each step. Second, the entire synthesis route should be as simple as possible. Third, there is a market for raw materials, and the easier and cheaper the raw materials are, the better.

The design of synthetic routes is a great test of the logical derivation ability of chemists, and at the same time, it is also necessary to be familiar with various organic chemical reactions.

Organic synthesis is based on a wide variety of carbon-carbon bonds and functional group conversion reactions, and to date chemists have developed thousands of synthetic reactions, with more than 500 commonly used reactions named after people.

Last year, Shen Qi couldn't completely remember all the names and reactions, but this year it's almost okay.

As for the purification and testing of reaction products, this is the basic exercise, regardless of whether you are a chemistry boss or a recent graduate of chemistry, you need to be proficient.

Becoming a good organic synthesizer is a comprehensive test, and route design is the first and most important step in synthesis work.

The determination of TM in route design is the beginning of the difficult beginning.

Shen Qi, Lao Yan, and Cheng Haonan returned to the center and began to hypothesize.

What to suppose?

For some purpose, they hypothesize a target molecular structure.

What kind of use is it used for?

Is it a cure for the sick and a life-saving medicine, or an invisible poison that kills people?

Is it a purifier of the healing system, or a source of pollution of the dark system?

There are no restrictions on the imaginary stage, and everyone gives full play to their imagination.

The principle of the hypothetical stage is that if the purpose of the target molecule cannot be determined for the time being, then its structural novelty should be considered.

Some of the new compounds may already have a certain use, and some may not know what the use is now, but it is also meaningful to be synthesized because of the novelty of the structure, and this compound is called a chemical treasure.

The most attractive and stimulating thing about organic chemistry is that it discovers new structures and creates new products.

How this is like God's work.

However, God's job is not easy, and unfounded and purposeful fantasies will inevitably lead to a waste of time.

Shen Qi's purpose is very clear, his hypothetical TM is either a super interesting new structure similar to C60 back then, or a chemical drug molecular structure that can treat his wife's illness.

After thinking about it all day, Shen Qi had a headache and couldn't think of it.

Shen Qi's worries at work disappeared instantly after returning home.

Shen Nuofei is more than seven months old, and she crawls around on the carpet in the living room, quite active.

"Wow wow!" Shen Nuofei opened her mouth and shouted when she saw Shen Qi, she realized that this man was someone she was very close to.

"Nofi, it's called Baba, it's Baba. Shen Qi squatted on the ground and taught his daughter pronunciation.

"Wow!" Shen Nuofei shouted energetically, but he couldn't clearly pronounce the sound of "Dad".

"Nofi, it's called Ma Ma, it's Ma Mala. "Ou Ye squatted beside Shen Qi, not to be left behind, the child was born by me, the milk was fed by me, my daughter must learn to be called Ma Ma first.

Shen Nuofei rolled over, she was too fat, she couldn't roll half of it, and she was stuck on the carpet.

Shen Qi helped his daughter complete the side roll movement, pointed to his nose with an expectant expression, and said earnestly: "Baba, baba." ”

Ou Ye pushed Shen Qi away and seized the advantageous terrain, she pointed to her head and said to her daughter: "Ma Ma, Ma Ma." ”

Shen Nuofei looked at Shen Qi and then at Ou Ye, she was puzzled.

"Baba, poop. Shen Qi is never tired of this, and teasing the baby is the happiest time of his day.

"You're big, you're done with the math unification work?" Ou Ye was determined to let his daughter call her mother first.

Shen Qi quibbled: "Wife, after your number theory section is completed, I can carry out the rest of the work! Nofi is good, called Ma Ma, called Ma Ma. ”

"Skin. Ou Ye smiled, Shen Qi still let her at home.