The capsule-like drug is developed and sold by Eli Lilly and Company of the United States, and the Chinese name of the American generic name is Leluoxianfen, and the trade name is Yiweisi.

This drug is usually called Le Luo Xianfen capsules in China, a box of twelve capsules, the domestic price is 9,006 RMB, and Ou Ye takes one pill a day before pregnancy.

The pill-like drug is developed and marketed by Novartis in Switzerland, and is known as Condokran in China.

Speaking of the Swiss pharmaceutical giant, the famous anti-leukemia drug Gleevec they produced used to be very expensive, known as a sky-high drug, and caused a storm.

The kind of condochlen that Ou Ye eats is not cheap, 12,000 RMB for a bottle, and two bottles a month.

Relying on drugs to hold a breath and maintain a glimmer of hope for the birth of new medical technology is the greatest motivation for every patient.

However, many patients cannot afford to take sky-high drugs, and medical insurance can reimburse some drugs, but they cannot afford every drug in the world.

It's expensive, and the root cause is the key.

Shen Qi operates chemical experimental instruments to conduct professional analysis of Leloxenin and Condochran, which is a comprehensive operation that requires mastering a variety of chemical knowledge and practical skills such as organic, inorganic, and analytical.

Shen Qi found through experiments that Leluosin is actually a benzothiafine compound, 800 pieces of a pill, swallowed and gone, it is really expensive.

Women have stronger immunity than men, which allows women to defend themselves against more infections.

However, due to the role of estrogen and progesterone in the immune response, it also makes women more susceptible to autoimmune diseases.

The main effect of leloxinfine is to regulate estrogen, which has a good effect on autoimmune diseases in female patients.

And the chemical essence of Condokrone is a class of oxazolidinone compounds, which is said to be the best anti-Mersian anemia drug in the world.

From a scientist's point of view, the so-called sky-high prices of drugs are not so mysterious, their essence is to obtain chemical products through chemical reactions.

"Chemistry, up to level 12. ”

"Creature, also give me a level 12 upgrade. ”

Zizi!

Tremor!

Shen Qi was stunned for a few seconds, then returned to normal, and both chemistry and biology were upgraded to level 12.

Level 11 is the standard master level set by the system, and chemistry and biology can only smash the high master level of level 12.

Level 13 is the top master, and certain conditions need to be met before it can be upgraded from level 12 to level 13.

The conditions for upgrading from Chemistry 12 to 13 are:

1. 4 million points or experience points;

2. Obtain any of the following chemistry awards to prove the master's level of the host.

The system has a list of Nobel Prizes in Chemistry, Wolf Prize in Chemistry, Welzi Prize in Chemistry, International Carbohydrate Prize, International Prize in Catalysis...... and more than a dozen internationally renowned chemistry awards.

The conditions for upgrading from level 12 to level 13 in a creature are:

1. 4 million points or experience points;

2. Cultivate at least five excellent biology doctors.

“...... The balance 30012781 points for Xueba, please confirm with the host. ”

The king of mathematics, physics, chemistry and physiology was born today.

Except for Shen Qi, there should be no one else in the world today with a level of 14 in mathematics and physics, and a level 12 in chemistry and biology.

If chemistry and biology want to continue to upgrade, Shen Qi has to achieve academic research results in the real society, or cultivate outstanding young talents.

It is difficult to win the Nobel Prize in Chemistry in grade 12, and Shen Qi can fight for other chemistry awards.

The field of biology has brought out 5 excellent doctors, which takes a lot of time, energy and feelings, and Shen Qi must first obtain the qualification of a doctoral supervisor in biology.

Mathematics and Physics double 14 levels, Chemistry and Biology double 12 levels, let's make do with it first.

Mathematics, physics and chemistry are not completely independent of each other, mathematics points out the direction, physics ignites sparks, chemistry is interspersed left and right, and biology follows.

When the level of mathematics, physics, chemistry and biology reaches a certain height, it can be integrated and established, which depends on the scientist's perception ability and integration methods.

Center 401 experiment, Shen Qi's laboratory alone, he is doing chemical experiments.

"Boric acid 43 was arylated with a suzuki coupling reaction. ”

"Benzothiapen 13 was obtained at a yield of 81%. ”

"The ionic liquid (N-methyl, 4-butylimidazole tetrafluoroborate) was recovered for use in the Friedel-Kratz reaction...... Ahem!"

When the Friedel-Kratz reaction is performed, a large amount of reddish mist is generated in the reactor, which is acidic and pungent.

Even though Shen Qi was wearing a mask, he couldn't help coughing, and while coughing, he flipped through the chemical literature.

It is written in the literature that Friedel-Kratz reacted that this was the case, asking the experimenter to wear a full set of chemical protection equipment and to maintain ventilation in the laboratory.

The Friedel-Kratz reaction is named after the two chemists who first discovered and reported it.

There are so many human name reactions in organic synthesis that it is difficult to memorize all the human name reactions and their principles and phenomena.

Shen Qi continued his chemical synthesis experiments.

"With a yield of 79%, 28C with a complete skeleton of Gloroxine was obtained. ”

"Introduction of 2-hydroxyethylpiperidine side chain by copper-catalyzed coupling reaction. ”

In this reaction, an ionic liquid (N-methyl, 4-butylimidazole tetrafluoroborate) is again used.

Snort!

An acidic, pungent, reddish mist permeates the air.

Shen Qi was not surprised, and he had psychological resistance.

Finally, in Lewis's acidic ionic liquid (trimethylaminoaluminium chloride salt), Shen Qi obtained leloxenfine with a yield of 43%.

Leloxinfine capsules are sold on the market for 9600 yuan a box and 800 yuan a capsule.

Shen Qi synthesized Le Luoxin in his 401 experiment by studying the instructions of Le Luo Xianfen capsules and related chemical literature, and using the actual object of Luo Xianfen capsules as a sample reference.

Theoretically, if Shen Qi's experimental procedure had not gone wrong.

Eli Lilly of the United States would definitely not tell Shen Qi the specific technical details of the preparation of Le Luoxianfene, and Shen Qi reversed the deduction and obtained Le Luoxianfene.

Whether Shen Qi's version of Lelocifene has the same efficacy as the American version of Lelocifene needs to be further verified.

Even if Shen Qi succeeded in copying Le Luoxinfine, he couldn't sell it, because Eli Lilly had already applied for a global patent for the drug.

There should be some chemists in the world who have Shen Qi's reverse thrust ability and operation level.

There is basically no difference between Gleevec produced by Indians and Gleevec in Switzerland, and it turns out that cheap Indian Gleevec can also save leukemia patients, and there must be chemical experts in the Indian people.

"Le Luo Xianfen, are you really effective?" Shen Qi observed his homemade Le Luo Xianfen, his wife had taken this medicine for many years.

It was very important for Shen Qi to verify the toxicological, pharmacological, pharmacokinetic and metabolic properties of the self-made version of Leloxinfine.

If Shen Qi succeeds in synthesizing the drug that Ou Ye has been taking for a long time in the laboratory, it will bring Shen Qi great confidence, and maybe one day, he can synthesize a new drug with better efficacy.

According to Eli Lilly and Company, they conducted pharmacological and toxicological experiments on mice and monkeys during the development stage of leloxinfine, verified the safety of leloxinfine, and were able to pass the FDA (Food and Drug Administration) certification and obtain marketing qualifications.

"Monkeys, where to get monkeys? Monkeys are all nationally protected animals. Shen Qi fell into deep thought, white rats are easy to apply, but primates used for animal experiments are not easy to handle, so you have to ask the medical department or the life science academy for help.