"Qi, when you come to the hospital, bring me something. Ou Ye called Shen Qi.

Shen Qi said while consulting the literature in his office: "Okay, what to bring?"

Oye: "Gauss's Notes, Volume 15. ”

"Huh, do you want to read this volume of Gauss's notes?" Shen Qi was a little surprised, the document in his hand was the 15th volume of Phillips-Klein's version of Gauss's notes.

There are 20 volumes of Gauss's extant handwritten notes in German, all of which are kept in German academic institutions and are not for sale. Even Gauss's portrait was printed on the Deutsche Mark that circulated in 1989~2001. It can be seen that Germans have great respect for scientists, and the heads of kings, queens or presidents are often printed on the currencies of other countries.

Gauss was the founder of the Göttingen School, and Phillips-Klein was the descendant of the Göttingen School of Gauss.

This Phillips Klein is the same Klein who was driven crazy by his good friend Poincaré.

After going berserk, Phillips-Klein lost his ability to solve mathematical puzzles, and in his later years he focused on writing the history of mathematics and translating 20 volumes of Gauss's notes into English, French, Latin, and other languages.

The English version of Gauss's notes, handwritten by Phillips Klein, was passed around several times and eventually found in the collection of the Institute for Advanced Study in Princeton.

When Shen Qi returned from the United States, he brought back 15~18 volumes of Gauss's notes in the English edition of Phillips-Klein.

The Germans would not hand over the original Gauss's notes in any form, and the Klein version of Gauss's notes is an antique artifact today.

In fact, Gauss's notes have long been published and translated into various Chinese languages by publishing groups and sold worldwide.

But mathematicians with status, status, a little spare money, and a little affection are more willing to collect manuscripts.

Shen Qi's own manuscripts were either given away or exchanged with other collectors.

Klein's English version of Gauss's notes 15~18 volumes were exchanged by Shen Qi.

Manuscript artifacts from more than 100 years ago should not be read often, otherwise they are easily damaged.

It was at the critical sprint moment that Shen Qi took out the manuscripts of various scientists in history for review.

He and his wife, as well as many leading mathematicians, believed that there was not only a distinction between manuscripts and printed materials, but also a vague spiritual imprint that had not yet been proven.

"OK, I'll bring you Gauss's notes later, what else do you need?"

"Auntie's towel. ”

"Okay, wait for me, see you in twenty minutes. ”

The needs of Ouye are extremely simple, academic and physiological.

As requested, Shen Qi took Gauss's notes and his aunt's towel to Ouye's ward.

"So wife, do you plan to cut from the Gaussian quadratic domain to rank greater than or equal to 2?"

"Well, I think it's doable. Odd, what do you think?"

"I think it's possible, so let's do it. ”

Shen Qi suddenly felt that his mood was very complicated.

Ouye could not find mathematical inspiration at home and even fainted.

Once hospitalized, Ouye seems to have entered a higher academic realm.

Shortly after Shen Qi left the hospital, some new reports came out in the international chemical community.

The UC Berkeley team said they had successfully synthesized a macrocyclic compound with 20 chiral centers and an isomer number of 2 to the 20th power in the lab.

"So fierce?"

This was Shen Qi's first reaction after seeing this report.

The Berkeley research team pointed out in the report: "We have referred to the research results of the macrocyclic compounds of the Yanda Shen Qi team and synthesized the macrocyclic compounds with the most chiral centers so far. The use of this macrocyclic compound needs further research, but we have made historic progress in the structure of the new compound. ”

According to the University of Tokyo research team, they have synthesized a new macrocyclic compound with an extremely complex structure in the laboratory. This new compound is similar to the chemical structure of sea anemone toxin, except that it is a macrocyclic structure with more than eight elements at key sites.

The research team at the University of Tokyo also thanked Shen Qi's team for providing the macrocyclic compound theory a few months ago, and they called the new compound "lighthouse jellyfish hormone", which they called the new compound to help reveal some mysterious problems in nature.

The research teams from Germany, the United Kingdom, and Australia also reported their latest research progress on macrocyclic compounds, and they proved through experiments that the theory of macrocyclic compounds and new rearrangement reactions proposed by Shen Qi's team is very reliable.

"This ...... It's a little out of control. ”

Shen Qi didn't know whether to be happy or worried.

The theory of macrocyclic compounds was proposed by him, and after the introduction of this set of theories, various new products with bells and whistles were derived in the hands of chemists from all over the world.

It is difficult to judge the potential practical impact of the new compounds with all the bells and whistles.

Shen Qi's intuition told him that the emergence of a large number of new macrocyclic compounds was a double-edged sword, which was used well for the benefit of mankind and deviated from destroying the world.

System: "The host completes the task of Chemistry Rank 14, level up!"

Requirements for Chemistry Advancement to Level 15:

1. 60 million points;

2. Use chemical means to reveal a mystery. ”

In any case, the promotion to grade 14 in chemistry is always worth the joy.

Mathematics and physics are promoted to level 14, all of which are pointed.

The system requires Shen Qi to solve some specific mathematical and physical problems before Shen Qi can be promoted to level 15.

Condition 2 for the promotion of chemistry to level 15 is open-ended, and Shen Qi needs to explore it by himself.

Yanda People's Hospital.

The tolerable administration of triazaoctene was fully completed.

The team of research physicians, led by Professor Qu, processed clinical data such as the number of individuals, mean, median, standard deviation, coefficient of variation, geometric mean, and geometric standard deviation through statistical methods.

Based on clinical observation and data analysis, Prof. Qu's team believes that triazaoctenein has passed the tolerance test, and all subjects will enter the pharmacokinetic/efficacy test.

Many literatures have reported that the success rate of new drugs in the clinical research stage is around 10%, that is, only one out of 10 drug candidates can be finally marketed.

Studies have shown that the main reasons for the failure of clinical development are efficacy (66%) and safety (21%).

It is the most basic requirement for a drug to have a good safety profile and not to die without serious side effects.

The core indicator that determines whether a new drug can be marketed is effectiveness, that is, the effect of the drug in treating patients.

In order to avoid the failure of high-cost drugs in phase III clinical trials, it is necessary to carry out proof-of-concept with efficacy as the indicator in phase I and II clinical trials, so that drugs that are not easy to develop successfully can be eliminated as soon as possible, so as not to waste money.

Based on the above clinical trial ideas, Ouye finally ate triazaoctene again.