Approaching the end of work, Shen Qi saw the experimental report of He Lin's research group.

Chemistry is an experimental discipline, and even the greatest ideas need to be verified by experiments.

In a seven-membered cyclic transition state reaction, [3,3] σ migrate to form a reaction to synthesize macrocyclic compounds, which is a ring-opening method and can be considered as a new rearrangement reaction.

The new rearrangement reaction led to the creation of new compounds, and what Cao Fan thought was a structurally abnormal target compound was in line with Shen Qi's original speculation.

Throughout the history of organic chemistry, new synthesis methods have confirmed some theories, led to the revision or even overturning of others, and created new compounds that had never existed before.

Some of these new compounds already had some practical use, and some of them were not known to be used for at the time, but were only created by chemists because of their structural novelty.

Anemone toxin is an unstable compound isolated from coelenterate sea anemones in 1971 by chemist Moore with a staggering C129H223N3O54 molecular formula that is more than 10 times more toxic than tetrodotoxin. In 1982, Moore published the three-dimensional structure of the compound, and in 1989, Professor Yoshito Kishi of Harvard University announced that the compound was successfully synthesized.

C129H223N3O54 is still the largest molecule of natural products thought to be chemically synthesized, and chemists synthesized it before the '90s, but at the time they didn't know exactly what the specific environment it should be used in.

In the 21st century, C129H223N3O54 finally realized its value, and the idea that "what God can do, chemists can do" has been widely spread in the international chemistry community, and Professor Yoshito Kishi has become one of the most outstanding chemists in the world.

Whether God can save my wife or not, this is not very clear.

So Shen Qi did it himself.

A new drug is necessarily a new compound, and a new compound can be synthesized using a known synthetic method, or of course, a completely new synthetic method can be used.

"It's a seven-membered cyclic compound, ?. Shen Qi left the office and headed to the chemistry lab.

In the laboratory, He Lin was teaching Cao Fan Director Shen's "Eighteen Pages of Heart Sutra".

Not long ago, Shen Qi sent an email to He Lin, the attachment of which was Shen Qi's experience on organic synthesis, with a total of 18 pages.

It was based on the "Eighteen Pages of Heart Sutra" that He Lin designed a new experiment, and the results of the experiment are available today.

"I'll just say, this rearrangement reaction is plausible, like a Cope rearrangement but not like it, it turns out that it is a rearrangement reaction newly invented by Director Shen!" Cao Fan suddenly realized, he was very excited, and he unconsciously completed a new reaction: "According to international practice, this rearrangement reaction should be named Shen Qi rearrangement." ”

"That's the International Chemical Organization's business, and it's not our turn to worry about it. He Lin said, "The rearrangement reaction invented by Director Shen is just a tool, not the ultimate goal. What he wants most is a representative or series of stable eight-membered or even nine-membered cyclic compounds, a new type of macrocyclic compound that can support a new set of theories, and at the same time produce new drugs that can effectively treat the rare diseases that plague patients. ”

"Magnificent setting!" After a two-month internship, Cao Fan finally learned the core secret of the LPJK1 project: "So this seven-membered heterocyclic compound is just an intermediate?"

He Lin nodded and said, "A very meaningful intermediate product, and then we will do a more in-depth experimental analysis of its stability." ”

Six-membered heterocycles widely used in drug synthesis include pyridine, pyrazine, pyrimidine, pyridazine, etc., and their planar structure is hexagonal and stable in nature.

Also stable are five-membered hybridizations, including furans, thiophenes, pyrroles, thiazoles, imidazoles, etc., and their planar structures are pentagonal.

The planar structure of the seven-membered heterocyclic compound is heptagonal, and it is not as stable as the five-membered and six-membered rings.

In the ever-changing world of chemistry, there are, of course, triangular ternary heterocycles, such as ethylene oxide. and square quaternary heterocycles, such as β-propionolactone.

Considering cost, availability and stability, five-membered hybridization and six-membered heterocyclic are the most cost-effective.

According to the drug naming convention, we often see a variety of commercial drugs with the words pyridine, pyrazine, pyrimidine, pyridazine, furan, thiophene, pyrrole, thiazole, imidazole and other words on the market. The main part of the role of these drugs comes from the five-membered hybridization and six-membered heterocycles in their chemical structure.

Why didn't Shen Qi follow the rules and focus on five-element hybridization and six-element heterocyclics?

Because after his calculation and analysis, he believes that the large ring of more than seven yuan is more suitable for the specific project he does.

What is the basis for the calculation and analysis?

It's math.

As mentioned above, the reaction of macrocyclic compounds above seven yuan is rarely developed, and the supporting theoretical system is not perfect.

So there is the rearrangement reaction of Shen Qi's new invention.

"He Lin is right, next we are going to do a stability test on this seven-membered compound. Shen Qi's voice sounded behind He Lin and Cao Fan.

"Director Shen!" He Lin and Cao Fan only found Shen Qi who had quietly come behind them at this time.

"I just finished reading your group's latest experiment report, and it's been a good job. Your group can get off work, let's go and eat, I'll please. Shen Qi did not hesitate to praise him, and of course he should give verbal and other encouragement to his subordinates who completed the task.

The four members of He Lin's research group happily followed Shen Qi to the restaurant outside, the weather was getting hotter, and each person ate a few catties of lobster and abalone to moisten the stomach.

At the dinner, Shen Qi talked about his thoughts on the LPJK1 project: "The first thing we need to do is to test the stability of the rearrangement reaction, the seven-member, and the subsequent eight-member, nine-member, or higher-element compounds. The stability of the compound is guaranteed, and we do the work of pharmacokinetic analysis, efficacy and safety, which is the work of animal experiments and clinical trials. The LPJK1 project is broken down into several task groups, the most important of which is your receptor coagulant group. If the project of the receptor coagulant group is successfully completed, LPJK1 is more than half completed. So keep up the good work, I will fight with you. ”

"Understood!"

"Clear!"

Shen Qi raised his wine glass: "I'm not strong enough to drink, and I haven't drunk for a long time." Everyone gathered at the table today, quite happy, I did it, you are free. ”

Shen Qi said that he would do it, and a glass of liquor instantly went down.

The leaders are bored, how can the subordinates raise goldfish?

Between the staggered planning, the team cohesion was further improved.

With a bottle of 52-degree liquor per capita, Shen Qi, who was overwhelmed by alcohol, became more sober the more he drank, while the four subordinates were red-faced and spit out the truth after drinking.