Chapter 446: Toxicology
The Shen Qi Mathematical Research Center began to relocate, moving from the third floor of the Mathematics Building to the newly built Central Building.
Finally having their own independent research base, the staff of the center are very excited.
Shen Qi made a simple arrangement in Room 401 on the fourth floor, and he asked Yang Dingtian to help him tidy up Room 401 together.
The FASTER project team is engaged in the research of amorphous materials, dealing with various chemical elements every day, and has some basic chemical instruments and raw materials.
Electronic balances, beakers, volumetric flasks, straws, triangular beakers, projection electron microscopes, ultrasonic suspension instruments...... These common instruments are available.
Shen Qi purchased syringes, gavage needles, glass specimen bottles, and dissecting instruments such as planing boards, surgical scissors, tweezers, and hemostats.
Yang Dingtian found a problem: "Academician Shen, these dissecting instruments should have nothing to do with condensed matter physics experiments, right?"
"Basically, there is no connection, by the way, Dingtian you have an orange cat, and you know more about experimental animals. You help me buy 10 istar rats, and 10 KM mice. ”
"Academician Shen, Laplace is a pet, our friend, it is not a laboratory animal!"
Yang Dingtian saw that Shen Qi was going to do animal experiments.
Many people say that Yang Dingtian is a weirdo and has a problem with his brain.
The weirdo has an advantage, and what others find strange, he thinks is just like that, and it is not worth making a fuss about.
Yang Dingtian quickly helped Shen Qi get 10 istar rats and 10 KM mice, and these two strains of mice were widely used in various animal experiments.
Shen Qi gently stroked the white rats, and then put them back in the cage, where they were delicious and entertained.
"Dingtian, I will go to Sweden to attend the Nobel Prize ceremony soon, and when I am not there, help me treat these white rats well, and don't let your cat eat the white rats, these white rats are scientific research assets. Shen Qi instructed Yang Dingtian.
Yang Dingtian accepted the task: "Don't worry, Laplace only eats cat food and canned food, and it hates mice the most." ”
Shen Qi continued to explain the details: "Animal experimentation is a cold thing in a sense, but for the sake of science, we must do it. In the process of raising animals, we must not expose animals to unnecessary injury, discomfort, hunger, panic, torture, pain and disease, and ensure that animals can achieve natural behavior, are well managed and cared for, and the individual animals are always in a state of well-being. ”
Yang Dingtian nodded: "Okay." ”
In fact, Shen Qi also knew that as long as anyone who entered the 401 laboratory, they could see that the scientific research tasks undertaken by this laboratory had nothing to do with physics.
What is the purpose of Shen Qi's animal experiments, Yang Dingtian did not ask in detail.
Shen Qi's original intention was to develop a drug to treat his wife's illness.
This kind of thing depends on how to explain it, if Shen Qi uses the country's scientific research resources to serve his wife alone, it is a violation of discipline.
Rising to a higher level, if Shen Qi serves patients with chronic diseases of the immune system and blood system all over the world and provides effective scientific solutions, it will no longer be for public use, but for the benefit of all mankind. Ouye is not the only one in the world who suffers from this disease.
Before developing a drug, it is necessary to stock up on experimental animals, cultivate the relationship between humans and animals, and keep the animals in a happy state.
It is a medicine that is three parts poisonous.
Thalidomide has caused limb deformities in more than 12,000 infant seals in Britain, France, Germany and other countries, and subacute spinal optic neuritis caused by chloriodoquine has caused tens of thousands of disabilities and nearly 1,000 deaths in Japan.
The eye-skin-mucosal syndrome caused by Pralolol occurs in 1 million cases worldwide every year.
The hemolytic anemia and renal failure caused by temafloxacin have caused the United States, Canada and Australia and other developed countries to suffer from poison.
Elevated blood pressure and arrhythmias caused by phenylpropanolamine hydrochloride, as well as heart disease and stroke caused by the non-steroidal anti-inflammatory drug rofecoxib, have also caused damage to Chinese patients.
There are many similar drug accidents, these famous drugs are developed and produced by famous European and American pharmaceutical companies such as Bayer in Germany and Merck in the United States, and are widely sold around the world, causing large-scale injuries and even deaths of patients.
Drugs are originally used to treat diseases and save lives, but while drugs have a positive effect on the target organs, they may also cause serious side effects and damage to other human organs.
So the scientific significance of toxicology is very important.
The word toxicology means "toxicological research", and modern toxicology studies the harmful (toxic) effects of the body's exposure to chemical, biological, and physical substances under certain circumstances.
Drug toxicology is a branch of toxicology, which mainly studies the inevitable systemic or local pathological changes of the body caused by drugs, and even caused irreversible damage or fatal effects in the process of human use of drugs to prevent and treat diseases. At the same time, it also studies the safety and risk assessment of new drugs before they are marketed.
Shen Qi is currently gathering the branch of drug toxicology, which is mainly supported by chemical and biological knowledge.
My wife's body is already fragile and can no longer withstand the additional damage.
Before making a pharmaceutical, we must first master various toxicological properties, which is an experimental science, and Shen Qi must do it himself to improve his skill proficiency.
Shen Qi said that he would do it, and the experimental animals selected were male mice, 18-22 grams.
First, the mice were infected with the pesticide atrazor, and then the mice were injected with 0.4 ml of serum with 5% SRBC in the peritoneum for immunization.
After being infected with the virus, he injected immune serum, and Shen Qizhi's purpose was to do a hemolytic plaque experiment, which was an immunotoxicity experiment.
The poisoned mice are still living happily, and Shen Qi observes the survival state of the experimental mice every day.
It wasn't until the fourth day that the experimental mouse developed symptoms of discomfort, and its short life was coming to an end, but its scientific mission would continue.
Shen Qi put on protective gloves and a mask and took out the mouse from the cage.
The mouse had begun to twitch slightly, and Shen Qi needed to end its pain as soon as possible.
The spinal dislocation method is an effective way to end the suffering of laboratory animals.
Shen Qi grabbed the mouse with his right hand and pulled it back hard, while his left thumb and index finger pressed down on the mouse's head, this simple operation was to pull off the spinal cord and cerebral spinal cord of the mouse, so that the mouse died immediately.
Click!
Shen Qi made a move, and his technique was sharp.
He closed his eyes and was silent for a second, this was a life after all.
Scientists must respect life, and while they will also end some lives, respect for life is indispensable.
Creak!
The mouse that was clicked did not die immediately, it twitched even more painfully.
it?
Shen Qi was embarrassed, the first time he implemented the spinal dislocation method, the strength was in place, but the pulling angle was slightly off.
Click!
Shen Qi performed the spinal dislocation method on the mice again, and this time it was successful, and the mice were sacrificed.
Shen Qi picked up surgical scissors and tweezers, quickly cut open the abdomen of the dead mouse, and took out the spleen.
Shen Qi had never killed a chicken before, this was the first time in his life that he had disemboweled, and he needed to quickly and accurately remove the internal organs of animals.
I wanted to vomit a little, but Shen Qi still held back. ()
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