Ouye's patient, he crawled on the ground in a reptilian position, shouting: "I like to sleep with female students, I have slept with more than sixty female students, hahahaha! What if I sleep, what can you do to me? Those female students can't even write papers, but it doesn't matter, as long as they sleep with me, I will let them graduate." Aha, what if you sleep, what can you do to me?"

Professor Qu shouted: "He Yuankai, that's enough!"

The patient suddenly hugged Professor Qu's thigh and began to cry: "Professor Qu, I am a patient, you have to explain the situation to them, I am a seriously ill patient, they can't take me away! I want to stay in the hospital, I want to be treated!"

Professor Qu waved his hand: "Take him away!"

The crazy patient was taken away, Shen Qi couldn't help but be alert, and Ou Ye had a disgusted expression.

"Lao Qu, what is the situation with this He Yuankai? I remember, he seems to be a triazaoctene clinical trial subject, right? His mental problem can't be a side effect of the drug, right?" Shen Qi was a little nervous, triazaoctene finally advanced to the phase I clinical stage, in case there were psychoactive side effects, it would be over!

"He's pretending to be crazy and stupid. Professor Qu shook his head and said, "This person is a university teacher, and I just received the news that he was investigated for embezzlement and misappropriation of project funds. ”

Shen Qi took a long breath, and at the same time was filled with righteous indignation: "Damn! How did such a morally corrupt person recruit him into the test group?"

Lao Qu looked up at the brilliant sunset in the sky at a 45-degree angle, and said in a deep voice: "In the eyes of doctors, there is only a difference between patients and non-patients. ”

Ou Ye was indignant: "This surnamed He, what a scum! He was investigated for embezzlement of public funds, and he slept with so many female students, so no one cares?"

Shen Qi said: "It is not uncommon for students to go to the teacher to ask for mercy if they can't write a paper or fail an exam, and they go to the teacher to ask for mercy. A few years ago, I published a paper on mathematical analysis, and 80% of the students in the math school failed, and some of the students who failed begged me to add a few more points...... I can't manage this, the teacher didn't force the student, it was the student who took the initiative to send it to the door......"

Ou Ye pinched Shen Qi's waist violently: "Shen Qi, I will allow you to organize the language and say it again." ”

Shen Qiyi said in a righteous manner: "Manage, you have to manage, you must manage! Other places are not under my control, but in Yanda, I must be in charge." Since then, the School of Mathematics has never invited me to produce exam papers for math students, and I haven't had papers for several years. ”

Ou Ye asked: "I remember the tragedy of the division and failure, in the end, it seems that only 30% of the students were suspended, and the remaining 50%, you let them all go?"

Shen Qi: "If the real score is more than 50 points, I have added a few points." It is not easy for students to come to Yan University to study, and the question I gave that time was really difficult. ”

Ou Ye became vigilant: "Did you sleep with a schoolgirl?"

Shen Qi waved his hand again and again: "No, no, no! The people who came to beg me were all male students." The Ph.D. students I took were all men."

"Oh. ”

"Lao Qu, let's talk about something serious and go to your office. Shen Qi asked Ou Ye to go back to the ward first, and he and Professor Qu discussed medical issues together.

After the tolerability test of the phase I clinical trial of the new drug, it is the test of pharmacokinetics and pharmacodynamics.

At present, triazaoctene has advanced to the stage of pharmacokinetic and pharmacodynamic experiments, in which the research team studies the absorption, distribution, metabolism, excretion and time course of the drug in subjects through PK, and studies the time course of drug action through PD.

Through PK/PD and related mathematical methods, combined with clinical observations, the phase I clinical data of triazaoctene have begun to emerge.

Including Ouye, there were a total of 60 Phase I clinical subjects.

As Ou Ye's husband, Shen Qi is most concerned about the tolerance and pharmacokinetics/efficacy indicators of triazaoctene in Ou Ye.

As the developer of triazaoctene, Shen Qi also needs to pay full attention to the clinical performance of these 60 subjects, including previous animal experimental data, as well as subsequent phase II and phase III clinical trials.

Whether a new drug can be marketed depends on its safety and efficacy in the vast majority of target subjects.

Shen Qi certainly hopes that triazaoctene will eventually be marketed, and his focus gradually shifts to other subjects.

Professor Qu showed Shen Qi the pharmacokinetic/pharmacodynamic model based on 60 subjects, which is currently a work-in-progress and needs to continue to supplement the data, but some trends can also be seen.

"Tmax and Cmax are obtained by actual measurements, AUC0~t is obtained by trapezoidal calculation method, and we use λ2 to find the estimation of t1/2 and AUCt~inf, which is a non-compartmental model, which is the main pharmacokinetic calculation method in pharmacokinetics, bioequivalence and bioavailability studies, and is also the legal calculation method in the new drug declaration. ”

"However, the parameters obtained from the non-compartmental model are sometimes difficult to use to establish PK prediction models and perform PK/PD correlation analysis, so in this clinical trial, we also used the AV model and conducted rigorous mathematical analysis. Director Shen, you see, this is sample 6, and after the drug enters the body of sample 6, it is distributed to the target of action, and after combining with the target, it produces pharmacological effects, which causes physiological and pathological changes, thereby bringing clinical therapeutic effects. ”

"Sample 6 data is good, who is this?"

"Sample 6 is your wife. ”

"Oh, yes, yes, it's 6. But sample 27 doesn't seem to be ideal. ”

"Sample 27 is He Yuankai, the university teacher who pretended to be crazy and stupid just now. ”

"Let's look at the overall modeling. ”

"The overall model is not ready yet, but it's okay, let's look at the process data. Director Shen, you see, we use LC-MS/MS analysis, and within the range we set, the relationship between drug concentration and its signal response is described by a weighted linear regression function, and can also be described by a binomial......"

"Get out of the way, I'll help you describe it in a binomial. ”

Shen Qi volunteered to undertake the calculation and analysis of the mathematical model, and after more than half an hour, he completed the binomial description of the overall model.

Compared with the weighted linear regression function description, the binomial description reveals a more nuanced relationship between drug concentration and its signal response.

"The Philippine Award winner made a move, and it was really different. ”

The phase I clinical trial of triazaoctene has reached the final stage, and the main work at this stage is data analysis and processing, and finally a written report is formed. When the research team and clinical team apply for new drugs or publish papers, they all speak with data and judge the research results with written reports.

Shen Qi helped Professor Qu make a binomial description, which accelerated the data processing progress of the clinical team.

From the available data, it can be seen that considering the maximum, minimum, and mean values, triazaoctene has great hope of passing the phase I clinical trial.

With the publication of Ouye's "Strong BSD Conjecture", many mathematical teams around the world have claimed that they have carried out the interpretation and verification of the "Strong BSD Conjecture".

These mathematics teams include the Bargava team of the Clay Institute, the Gong Changwei team of Columbia University, the Lindon Strauss team of the Weizmann Institute in Israel, the Adama team of the University of Oxford, the Su Wenxie team of Mizuki University, and the Tao Zhexuan team of UCLA......

The interpretation and verification of the "Strong BSD Conjecture" seems to have formed a kind of academic competition.

Formal academic institutions and well-known mathematicians from Europe, America and Asia have taken action, and civil scientists from all over the world are not far behind.

A retired math teacher at Ouye's alma mater at Ouye High School declared on a video website with a large amount of traffic: "I have verified that Ouye's 'Strong BSD Conjecture' is true, and I don't have to thank me, this is what I should do." ”

The retired math teacher showed a few verification manuscripts in the video, which looked so professional.

At the end of the video, the retired math teacher said: "Come to the Little Genius Math Class and help your child win the gold medal in Olympiad mathematics, and the success rate of sending to a prestigious school is as high as 98%!"

"It turned out to be an advertisement!" netizens complained one after another.

Some netizens also think: "In these years, advertising training classes also requires technical content, at least the math teacher's verification manuscript is very professional." ”

Folk Crouching Tiger, Hidden Dragon, maybe there are really peerless masters such as sweeping monks.

There is no doubt that Mr. Liu, the instructor of the Pomegranate Math Class in Experiment 2, is a master.

Mr. Liu graduated from Fudan with a Ph.D. in mathematics, he is an officer of the Chinese Mathematical Society, and was the algebra coach of the Chinese Olympiad National Team.

Mr. Liu is very experienced in mathematics competitions, he is a meritorious coach, he has trained many IMO gold medalists with full scores such as Shen Qi and Zhou Yu'an, and helped the Chinese Olympic team to dominate the IMO team championship for five consecutive years.

Doctor of Mathematics from a prestigious university, secretary of the Chinese Mathematical Society, and meritorious coach of the Olympiad National Team...... With such a prominent experience, why is Ms. Liu willing to serve as an instructor in an elite mathematics class in a primary school?

There must be a shocking secret hidden in it.

"Shen Nuofei, can you solve this equation?" Teacher Liu knocked on the blackboard of the small classroom, he was not the teacher of the second experimental elementary school, he was hired by the second experimental elementary school with a high salary.

There was only one student in the small classroom, and she was Shen Nuofei.

Arranged by the Mathematics Teaching and Research Team of Primary 2, when Student Shen Nuofei of Class 1 (2) is in Mathematics class 1 (2), she will go to the small classroom and receive the careful guidance of Teacher Liu of Pomegranate Mathematics Class alone.

The equation on the blackboard is, 12-3(9-x)=5(x-4)-7(7-x)

This unary equation problem is taught in the fifth grade, and for most first-grade elementary school students, this problem is definitely beyond the curriculum.

But for Shen Nuofei, it is normal to be supernatural.

A week ago, the question was overrun.

Now, under the tutelage of Mr. Liu, Shen Nuofei has mastered the core technology of the one-dimensional equation.

Shen Nuofei nodded and said, "Teacher Liu, I will do this question." ”

Teacher Liu handed half of the chalk to Shen Nuofei: "Come, you write the steps to solve the equation on the blackboard." If you give the correct answer, then we immediately move on to the teaching of multivariate equations. ”