What Academician Zhong saw can no longer be described in words, a problem that the whole world cannot solve, at this time on the first day of the Chinese New Year, was suddenly solved?

At this moment,

Academician Chu, who was on the other end of the phone, heard the rapid breathing of his colleague Lao Zhong, and was a little dazed for a while, and asked curiously: "Old Zhong... What the hell are you seeing, and how do you feel like you're starting to breathe fast?"

"I..."

"I couldn't believe it... What you see. Academician Zhong said sincerely: "Solved! Finally solved... I briefly compared the two data reports, and the end result was just a touch..."

At this point, the words came to an abrupt end.

What Academician Zhong wanted to say suddenly stuck in his throat, his expression gradually changed from the original shock to a little frightened, as if he saw something that subverted his perception of knowledge.

"That's not right!"

"No, no, no, no!" Academician Zhong's frightened face, repeating a word constantly, the hand controlling the mouse kept sliding the wheel, his eyes became a little frightened at this moment, he found something that could not exist at all.

"What's wrong?"

"What the hell is going on?" Academician Chu was going crazy at this time, and he couldn't wait for wings to appear on his back, and then flew to Academician Zhong to see what he saw, this god mysteriously hung out people's appetites.

"Professor Xu Mang... He... In his new CRISPR-Cas gene editing system, he replaced Cas9 with another RNA-directed nuclease. Academician Zhong said in surprise: "This is incredible... Too... It's amazing!"

Academician Chu: ???

The more you can't see something, the more you want to have it.

Academician Chu was going crazy, listening to the constant exclamations of his colleagues, eating away at his curiosity little by little, and he was about to collapse at the last point.

"Oh my God!"

"Not only did he upgrade the CRISPR-Cas gene editing system, Professor Xu Mang also solved a... A question that bothers all biologists around the world!" Academician Zhong hurriedly said: "He redesigned the C2c1 nuclease, and now... The C2C1 nuclease has been fully adapted to the vast majority of organisms!"

Suddenly,

Academician Chu has completely collapsed, if the successful upgrade of the CRISPR-Cas gene editing system is just the beginning, then about the redesign of the C2c1 nuclease is the last straw that broke the camel's back.

The C2c1 nuclease has the property of thermophilism, which is simply not possible to develop into a gene editing tool, and the key is that the original structure of the C2c1 nuclease will cleave the non-target single stranded DNA in the double-stranded DNA, and the lower the temperature, the more errors, resulting in lower editing efficiency.

This problem is a problem all over the world, and many teams have tried and failed... However, Professor Xu Mang managed to break this dilemma?

This...

Is this killing two birds with one stone?

"Old Bell!"

"Hurry up and send me the data!" Academician Chu couldn't wait to urge: "I'm tickled by you... Hurry, hurry... Send me a quick moment, what's going on with this so-called redesign of the C2c1 nuclease?"

"Ahem!"

"This only describes the role of the redesigned C2c1 nuclease, but does not give a detailed report. Academician Zhong frowned and said solemnly: "Wait a minute... I need to give Professor Xu a call and ask what the situation is. ”

Words fall,

Academician Zhong hung up the call directly, and then hurriedly called Xu Mang.

"Hello?"

"Professor Xu... You have redesigned the C2c1 nuclease, is this true?" Academician Zhong asked nervously: "Is there any relevant research report? And this needs to be verified by experiments, and AI simulation alone is not enough to convince people. ”

Xu Mang said indifferently: "There are relevant research reports, although there have been no experimental verifications, but from the world's research reports on C2c1 nuclease, the use of AI technology... The results have been fully obtained, and it is not that C2c1 nuclease cannot be used for gene editing, but it is very suitable. ”

"To put it simply..."

"The CRISPR-C2c1 gene editing system I developed has higher sensitivity, which can achieve sensitive DNA detection and at the same time can achieve single-base discrimination. Xu Mang smiled: "With my gene editing system, I can quickly detect bacterial and viral infections, genotyping, and SNP mutations in cells, blood, animals and plants." ”

"Wait a minute, I'll let Xiao Zhang and Xiao Cai help me get the data for the experimental part. Xu Mang smiled and said, "That's right... Can Academician Zhong apply for a patent?"

“...”

"Yes!"

"You can give it to us for free. Academician Zhong hurriedly said: "That's right... Call me as soon as the result is available. ”

"Hmm!"

"I want to publish it in Nature, right?" asked Xu Mang.

Academician Zhong hurriedly said: "It's completely possible!"

Hang up the phone,

Academician Zhong sent all six documents to his old friend's e-mail, but only half an hour later, he received a call from Lao Chu.

"This..."

"This is a bit unbelievable!" Lao Chu's words were full of surprise: "It's just a research report on the redesigned C2c1 nuclease, if Xu Mang can publish it, it will be even more perfect!"

"This is just the beginning... A new gene editing system like this one needs to be continuously accumulated with experimental data and continuously improved on the original basis, but... Being able to put forward such a framework concept is enough to prove the greatness of Xu Mang. Academician Zhong smiled bitterly: "Old Chu... I have to sigh that the back waves of the Yangtze River push the front waves, and one wave is stronger than the other. ”

meanwhile

Xiao Zhang and Xiao Cai were very helpless, and the two were arrested by Xu Mang again, but this time the two did not have any complaints, and they came into contact with Xu Mang's latest research results, about the redesigned C2c1 nuclease.

At this point,

The two are conducting experiments on this new CRISPR-C2c1 gene editing system, while at the same time processing the C2c1 nuclease in more detail.

And this process,

It took two whole days, and for Xu Mang, he didn't feel anything in the past two days, just sitting in the laboratory knocking melon seeds and sending WeChat messages with Xiao Man, but for Xiao Zhang and Xiao Cai, these two days have been very rewarding.

As a new intern researcher at the institute, it is rare to have access to such top-level research projects, but Professor Xu can not care about his own experience and let himself join this research and become a part of this research, this kindness is simply unrequited.

"Are you alright?"

"This speed is okay..."Xu Mang said with a smile: "You guys go and rest... Or go outside, I'm here for the research institute. ”

Not to mention,

At this time, the two of them were exhausted, and after saying hello to Xu Mang, they hurried back to their dormitory.

Xu Mang checked the relevant research reports, silently went to his office, turned on the computer and began to edit the paper, and wrote the name of the paper at the beginning - "CRISPR-C2c1 Gene Editing System".

...

London

The headquarters of the famous scientific journal Nature,

Originally, this day was an ordinary day for the editors of Nature, but some people didn't want to make life too easy for this group of people, and at this time, a paper that was about to shake the world was quietly coming to the mailbox of the editor-in-chief Pitt.

"Nature's Top 10 People of the Year are published in this order. Editor-in-chief Pitt said to one of his subordinates, "Be careful about the order. ”

In the list submitted by the editor-in-chief of Pitt, Xu Mang was ranked first, there was no way... Although the entire Western world does not want to see Xu Mang ranked first, his achievements in this year can no longer be controlled by shady scenes.

"Editor-in-Chief Pitt..."

"Let the Chinese people come first... A lot of people are very upset. The young editor said, "Or... Move back a bit?"

"No way!"

"I can't move at all. Editor-in-chief Pitt said seriously: "If you look at the achievements of the next nine, they add up to only half of Xu Mang, what theory do you think there is to prevent Xu Mang from being in the first place?"

Time

The young editor was speechless, and this was really the case.

moment

There is only one editor-in-chief left in the office, and I don't know what happened recently, the quality of the paper is very poor, and the man he was expecting has not appeared, probably because Hua Guo is in this stage of their so-called Chinese New Year.

Belch?

New Email Alert?

It shouldn't be Xu Mang, he is celebrating the most important festival in China, since this is the case... Who sent this?

Editor-in-chief Pete didn't care, and he didn't click on it, silently doing his own thing, at this time, he summed up the email just now into the category of unfamiliar contributors.

Bang bang bang,

There was a knock on the office door, and after a call to enter, a middle-aged man walked in.

"Pitt editor-in-chief. ”

"Which of these three papers should be chosen as the cover paper?" The middle-aged man handed the text articles of the three research reports to Pete.

After a brief flip through it, there was a trace of dissatisfaction between the eyebrows of Editor-in-Chief Pitt, and he said seriously: "It's not shocking enough... Although it can be placed in the main journal, it must not be placed on the cover, and these three research reports did not excite me. ”

This middle-aged man is quite helpless, how can there be so many papers that can shock the whole world.

"Editor-in-chief Pitt... The quality of recent papers is generally not high, it may be that Valentine's Day is coming..."The middle-aged man smiled bitterly: "Many young scientists also need a touch of romance." ”

“...”

"It doesn't seem to have anything to do with Valentine's Day, it's just a low point. Pete laughed, "Wait... Anyway, there are still two days to go, and maybe in these two days, we can receive a research report that shocks the world. ”

Then

Pete opened his mailbox and saw the name of the first email - "CRISPR-C2c1 Gene Editing System".

"Huh?"

"By the way, do you know what a CRISPR-C2c1 gene editing system is?" Pete couldn't help but be stunned when he saw the email title, and asked curiously, "I remember... There is no CRISPR-C2c1 gene editing system in this world, right?"

"Probably not. ”

"The CRISPR-Cas9 gene editing system is available, and it is very popular in the biological field at the moment. The middle-aged man said.

Pete frowned and subconsciously clicked on the email.

In just a few seconds,

Pete shouted in horror, "It's him!"

......