"Here are two special guests!"

A pioneer in the field of gene editing, Professor Burton Richter of the Department of Biology at Stanford University. ”

moment

Professor Burton Richter came to the stage, but he was angry about calling himself on stage first, the more heavyweights on this occasion, the more he would appear at the end, but he never expected that he was in front of Xu Mang, and there were only two guests.

"Next up is the authority in the field of physics, the Nobel Laureate in Physics... Professor Xu Mang!"

As soon as the voice fell,

Xu Mang came to the stage with his smile, and his position was next to Professor Burton Rich, and a few meters away from the supporters, it was a very standard conversation mode, it seemed that the organizers were very attentive, of course... It is possible that there are also ulterior motives, who knows what tricks to play in the United States.

Looking at Xu Mang, who looked calm on the stage, a group of foreign experts in the field of gene editing in the audience were very uncomfortable, if this guy was biological, it would be okay, but he was engaged in theoretical physics research, and then became the most cutting-edge figure in the field of gene editing.

After that, there was a very boring greeting session, Xu Mang was completely indifferent to this link, asking and answering, the whole state was incompatible with this elite forum meeting, and for a while, the smell of salted fish permeated the entire venue.

"Professor Burton Richter... What do you think about the future of gene editing?" the proponent asked.

"The situation is not so good, and American scientists are beginning to lead the world in this fiercely competitive field. Professor Burton Richter said solemnly: "Recently, our research team at Stanford University found that the existing gene editing technology can accidentally damage a large number of ribonucleic acids while modifying DNA. ”

"Based on this discovery, we have invented a gene editing technology that will not cause accidental injury, with a success rate of more than 97%, making gene editing safer and more efficient, and providing an important safety guarantee for it to enter the clinic. ”

Words fall,

Professor Burton Richter glanced at the silent Xu Mang and asked curiously, "Do you have any opinion on the technology we have discovered?"

"Huh?"

"Oh... Pretty good technology. Xu Mang nodded with a confused expression, but his tone was extremely serious: "Work hard, strive to be equal to us in the past two years, I will be in the first position in the world, watching you work hard." ”

Professor Burton Richter: @#¥%...!

Furious!

It's so arrogant!

It's not just Professor Burton Richter who is angry, but many European and American gene editing experts present feel a hot pain in their faces, this is not as simple as shame, this is simply on the head of the United States!

"Ahem!"

"What's that... Professor Burton Rich, can you tell us more about this technology?" the host hurriedly changed the subject, and before coming to this venue, the organizers had already found him and told him about the possible situations, including Xu Mang's mockery of others.

"Good!"

"We have already patented it and are promoting its clinical and industrial translation. Professor Burton Richter said seriously: "Venture capital has been involved to accelerate the transformation of basic research into clinical and industrial research. ”

"Really?"

"What are the specific clinical diseases?" the supporter asked.

Professor Burton Richter coughed lightly and said seriously: "Worldwide, there are more than 7,000 rare diseases that plague human beings, of which about 80% are monogenic inherited diseases, such as thalassemia, hemophilia, retinal macular degeneration, hereditary deafness, etc. ”

"Theoretically, it is easy to use gene editing technology to correct these natural mistakes and restore the health of hundreds of millions of patients. Professor Burton Richter continued: "But to date, only two or three gene editing technologies have reached the clinical trial stage due to uncertainty about safety. ”

Then

Xu Mang raised his head and glanced at Burton Richard beside him, although this guy was very annoying, his ideals were noble.

"To cure a genetic disease, it is often necessary to genetically edit trillions of adult cells, and if the editing is not precise enough, the wrong cells can lead to risks such as cancer. Professor Burton Richter said solemnly: "Most gene editing technologies use viruses as vectors and then send editing tools to wash cells. ”

"Despite the presence of navigation molecules, there is still off-target, and even the latest editing tools discovered by Professor Xu Mang will be off-target, although he himself says no. Professor Burton Richter smiled indifferently: "I have discovered the fatal flaw of the CRISPR-C2c1 gene editing system. ”

“！！！”

“！！！”

“！！！”

moment

The scene began to come alive, and everyone's eyes widened as they looked at Professor Burton Richter expectantly.

"I'll mention the fatal flaws of Professor Xu's CRISPR-C2c1 gene editing system later, and now I'll move on to the technology we discovered at Stanford University. Professor Burton Richter smiled, "Please be calm. ”

Xu Mang: [txt ](「_「)

Specially,

Whether his ideals are high or not, it's none of my business... I'm going to kill you later!

"Human DNA has more than three billion bases, one percent of which is a gene fragment, and the rest contains information about non-coding RNA and other molecules involved in life activities. Professor Burton Richter said: "We have a testing system in place. ”

"Then the single-base gene editing technology, which was supposed to be safe, can cause 20 times more mutations than normal. "We have developed a gene-editing technology that does not cause accidental injury. ”

"The encoding RNA can directly produce proteins, and it is also the second delivery tool that turns DNA into proteins, and changes may directly affect life activities. Professor Burton Richter continued: "The progress is very impressive. ”

Words fall,

There was applause at the scene, and almost everyone was excited about it, finally having a technology comparable to the CRISPR-C2c1 gene editing system, and... The CRISPR-C2c1 gene editing system has huge flaws, and basically China cannot keep the world's first place.

As long as...

Professor Burton Richter has made it public that there is no room for redemption.

"Professor Xu Mang?"

"Do you have any thoughts on the technology developed by Professor Burton Rich's team?" asked the moderator.

Opinion?

What can be said.

Xu Mang said listlessly: "It's okay, but... I now want to know what the fatal drawback of the CRISPR-C2c1 gene editing system is. ”

"Good!"

"Since Professor Xu Mang wants to know so much, I will publish it. Professor Burton Richter said with a smile on his face: "Although the success rate of the CRISPR-C2c1 gene editing system is very high, and the success rate can be 100% with AI, but... There are some genomes that are incorrect, and even AI cannot detect them. ”

"We have to use our technology!"

Words fall,

Professor Burton Richter took out a data disk, handed it to the moderator, and said, "Please show the contents on the back display screen." ”

Just for a moment,

Everyone, including Xu Mang, saw the following sets of data.

"Based on the existing publicly available CRISPR-C2c1 gene editing system, our team has calculated that the failure rate is as high as more than 15% in the face of early aging syndrome and blood sweating, which is intolerable!"

"But don't worry!"

"The technology we have developed at Stanford University has a very significant effect on genetic diseases, which can compensate for the shortcomings caused by the CRISPR-C2c1 gene editing system. Professor Burton Richter said earnestly.

At this point,

Xu Mang turned his back to everyone, looked up at the huge display screen in front of him, and fell into confusion for a while.

Ay?

Why did you forget these two in the first place?

Xu Mang frowned, thinking about why he had forgotten these two genes, and finally he thought of the reason, which was a problem with the database... Neither genetic data appears to have been recorded.

"Professor Xu?"

"Professor Xu?"

The host saw Xu Mang looking at the screen in a daze, and hurriedly asked him: "Are you surprised that there is such an error in the CRISPR-C2c1 gene editing system you developed?"

"Uh..."

"Nope. ”

"Science is all about exploration, self-denial, and the database that the CRISPR-C2c1 gene editing system relies on doesn't include these two genes, after all, these two genes are too rare, but... That's not the reason. Xu Mang said seriously: "I admit that there is a huge defect in the CRISPR-C2c1 gene editing system in front of these two genes. ”

“...”

“...”

At this point,

Xiao Zheng and Xiao Yi were particularly unconvinced, and sure enough, Professor Xu Mang was taught by others, and this group of hateful Americans took the only mistake and pointed out that Professor Xu Mang's discovery was flawed, what kind of joke did they make?

"Damn!"

"It's so damnable!"

"This group of people is shameless!" Xiao Zheng said angrily: "Professor Xu Mang's CRISPR-C2c1 gene editing system, after our experimental testing, the success rate is very, very high. Damn!"

"Not really!"

"Stanford University's technology is still only under development, so dare to show it off?" Xiao Yi said angrily: "I'm so angry!"

Angry to angry,

But what to do after that?

Xiao Zheng and Xiao Yi are quite worried about Xu Mang, Professor Xu Mang has already torn open a wound, and these people will definitely rub salt on the wound.

"Ahem!"

"Host?"

"Isn't it my turn next?" Xu Mang said expressionlessly, "Isn't it time for me to show everyone?"

“？？？”

“？？？”

“？？？”

Everyone looked at Xu Mang at the same time, with worry and a hint of expectation in their eyes.

......