Why are cancer cells able to multiply rapidly and indefinitely?

Because cancer cell telomeres are not damaged, telomerase maintains the length of cancer cell telomeres and allows them to expand unlimitedly. The telomeres at the top of the chromosomes shorten every time a normal cell divides, and when the telomere damage can no longer be shortened, the cell cannot continue to divide.

This is an epigenetic phenomenon, so back to the regulation of gene expression in the molecular field, the secretion of telomerase in cancer cells and the continued health of telomeres are still related to the expression of gene fragments in cancer cells.

Telomeres of ordinary cells go from healthy to damaged about 100 times of mitosis, so is it possible to use the telomerase expression of cancer cell genes to make the telomeres of healthy cells damage after 10,000 or more times of mitosis?

Also, is it possible to increase the mitotic rate of cells after providing enough nutrients to them, so that they can proliferate rapidly.

The rate of cell proliferation can be as geometric as that of bacterial culture, that is, it can proliferate infinitely rapidly within a certain range in the form of 2 to the nth power.

Gao Siqi can only give a thumbs up to Xiao Ming's thinking!

"If we follow this route, we will not only be able to create a small amount of Kobe beef, but also find out the sufficient conditions necessary to prolong life. ”

Gao Siqi said with longing: "After overcoming the problem of cell death and proliferation, how far are human beings from immortality?"

Xiao Ming interrupted Gao Siqi's wonderful fantasy and said, "The death of cells is far from being as simple as we discussed just now, what we just pointed out is only a necessary condition, but it is far from a sufficient necessary condition. However, according to our current level of technology, it is certain to change the basic agricultural level of the Xia Kingdom. ”

"There are two sides to everything, including cancer cells. ”

Borrowing the expression of cancer cell genes to express the genes of normal cells, in order to grow Kobe beef in the laboratory, this is definitely a healthy food, and the final product is exactly the same as normal healthy beef in terms of muscle tissue, fat structure, and gene fragments, not cancer beef.

In the laboratory, the proliferation of cells is infinite proliferation within a certain range, not infinite proliferation without range, and there is no such absurd thing as the muscle cells of beef will rob the healthy cells of nutrients and proliferate indefinitely in the stomach after eating beef.

With a clear experimental idea and a relatively mature technology, the next experiments will progress much faster.

Half a month later, in mid-November, when the Kobe beef purchased from Shanghai was completely destroyed in the laboratory, a new Kobe beef was born in the laboratory's incubator.

Gao Siqi took the beef from the culture vessel in front of Xiao Ming, and then refrigerated it for 28 days in a constant humidity and temperature-controlled environment according to the preservation method of Kobe beef (simulated storage in a constant humidity and constant temperature controlled environment).

It was supposed to take 28 days, but in the case of laboratory simulations, it only takes 30 minutes later.

"Unbelievable!" Gao Siqi took the experimental beef out of the freezer and said, "It's unbelievable that this is actually created in the laboratory, and it looks exactly like the real Kobe beef."

In the world of technology, experience is important, but it's the data that speaks for itself.

Xiao Ming said: "Send it for inspection." ”

Freshly baked lab beef is sent to the laboratory for testing.

The laboratory here is not only the detection of energy and nutrient content in beef, but also the most important genetic test.

The fineness of genetic testing should be detected in every base pair and arrangement, and it should be most comparable to real Kobe beef.

Three days later, the test results came back.

Xiao Chu said: "Minister Gao, you can change your career." ”

Gao Siqi smiled: "Okay, Xiao Chu, don't sell it to me, tell me the result directly." ”

"You can go out and turn right and go to the vegetable market in Hanrua Village to sell beef. ”

Gao Siqi and Xiao Ming's Qinghe I equipment appeared at the same time, and the indicators of laboratory beef were completely consistent with the indicators of real Kobe beef, including gene fragments and permutations.

"Perfect!" Gao Siqi said excitedly, and it was the best feeling to get results after putting in the effort.

Xiao Ming proposed, "Try the taste?"

This time, the lab created a total of 10 kilograms of beef, all of which were premium meat. If it is sold at a price of 4,000 yuan a catty in the Shanghai market, such a little meat is worth 40,000 yuan.

The members of the experimental team raised their hands to agree with Xiao Ming's idea, and used indicators to speak in everything in the experiment, but in the eyes of foodies, everything spoke with their mouths.

"Xiao Liu, Xiao Liu, take this meat down and make it, it's still a steak, I want it to be medium-rare. Gao Siqi said: "I have always been worried about domestic beef, and the steak is fully cooked, this is the beef in our laboratory, there are absolutely no parasites, and you can taste the taste of medium rare." ”

"I'm going to get cooked. Xiao Wang of the laboratory said.

"Xiao Huang, your taste is so heavy!"

Xiao Wang said: "Where is it, if the food safety of Xia Kingdom can be like our laboratory, I really like to eat raw, and the nutritional value of uncooked food is high." ”

"Gotcha!" Xiao Liu said.

The lab's office was simply sorted out and turned into a makeshift dining room.

Gao Siqi's group plus Xiao Ming, a total of twelve people, sat in their seats and waited for Chef Liu to serve the food.

"I feel the scent. ”

The steak was served by the staff one after another, and the presentation was first-class and the fragrance was first-class.

Xiao Ming ordered the medium-rare filet, tried it, and it tasted really good.

Although Xiao Ming has never eaten Kobe beef, the taste of this meat is better than that of steak he has eaten in the past.

Xiao Ming said: "Actually, I think it is more delicious to roast beef with traditional bamboo shoots in Jiangcheng. ”

Gao Siqi is also a person who has been abroad, has been to the East, and has also tried real Kobe beef.

She was full of praise and said, "It's delicious, it's really delicious! It's not much different from real Kobe beef." ”

Twenty minutes later, the powerful researchers had all ten pounds of beef.

Xiao Chu looked at the crowd feasting, and said, "Come on, don't sell your experimental products to the outside world, you don't have enough to eat." ”

Xiao Ming shook his finger and said: "Kobe beef is just the beginning, we have found an experimental method so that we can change the current agricultural methods of Xia Kingdom, industrialize traditional agriculture, improve production efficiency, ensure food health and safety, liberate the hands of farmers, and liberate the pressure of the land of Xia Kingdom." ”

Xiao Chu said: "Actually, you have selfish intentions, let Jiangcheng become the world's greatest science and technology city, and let the world's top talents be willing to stay here." ”

Xiao Ming smiled.