Chapter 133: Large-scale scientific research seminars
For the academic circle of Jinxi Province, these days are very extraordinary days.
The large-scale academic seminar jointly organized by Jinxi University of Traditional Chinese Medicine and 15 colleges and universities in Jinxi Province was officially held!
This is a lecture on academic exchange and experience, and the keynote speaker is Koo Drapeps, associate editor of the world-class journal "CELL", and the other speakers are well-known scientific research professors and editors-in-chief of the journal in Jinxi Province.
It can be said that this is the largest seminar on academic research held in the history of Jinxi Province.
This meeting attracted great attention from the Provincial Health and Family Planning Commission and the Provincial Department of Education, and specially approved the Provincial Gymnasium.
Of course, one of the main reasons is that the number of participants in the seminar is too large, and the general academic exhibition hall cannot fit in.
For a time, this meeting also attracted the attention of countless people from all over the country.
After all, in everyone's impression, Jinxi has always belonged to the weak area of master's degree and scientific research, but I didn't expect to invite the deputy editor-in-chief of "CELL".
This matter is also boiling, attracting the participation of many academic enthusiasts and scientific research workers.
However, when everyone paid attention to this matter, Bai Ye went to the hotel to study the data day and night.
This data is too messy and messy.
But......
This is not a bad thing, it can even be said to be a good thing!
Why?
Because Bai Ye found that there are actually many core technologies hidden in it, and these technologies are unique to large foreign scientific research bases.
After two days of research, Bai Ye was able to roughly figure out what the data was.
For unknown reasons, Koo did not make it clear.
This is the whole process of research and development of a new drug.
This process took more than 3 years.
Perhaps the later clinical trial process took longer, ten or eight years, although I don't know why the data behind it was lost.
But this process is already precious.
He has a complete and mature new drug research and development system from the conception stage of drugs, to the preparation of new drugs, to the design of new drugs, the development and production of new drugs, and clinical trials.
This drug is very valuable, and it is a molecularly targeted drug for the treatment of malignant tumors.
At present, the cause of the tumor is still unclear, so this experiment is through single-cell sequencing, that is, a single cell is used as a template for downstream next-generation sequencing research.
At present, the most common single-cell sequencing is used in the direction of tumors.
After Bai Ye saw this high-tech thing, he suddenly felt that his head was not good.
One of the most difficult directions in bioengineering is genetic engineering, and the first step of this experiment is genetic engineering, which is the most cutting-edge scientific research direction in the world.
The development of second-generation sequencing technology has made people aware of the increasingly serious relationship between human diseases and genomic variation.
However, the occurrence of tumor disease occurs precisely at the monoclonal level, which makes the detection of nucleotide level variation in a single cell very necessary.
And the content of the first most part of the data is precisely for this experimental implantation stage, those preimplantation, prenatal, screening embryos, etc...... Conduct a systematic analysis.
Single-cell sequencing mainly involves single-cell genome sequencing and transcriptome sequencing, which analyze and compare the DNA and RNA of a single cell, respectively, so as to reveal changes in the genome and transcriptome.
And the first big stage of data is mainly to observe, to observe the transcription and translation process of single cells.
And their experimental process, which is mainly to continuously culture single cells, and then cause cancer under various external conditions, this process is within the scope of detection.
Take a closer look at a variation in DNA and RNA during transcription and translation.
Of course, this is the process of experimentation, but this is not Bai Ye's job, Bai Ye's job is to study data.
However, this kind of molecularly targeted drugs, especially those that study at the gene level, are rare in China, and the experience and technology in this area are insufficient.
Through these observations, the results are found.
Bai Ye's calculations were smooth, and the initial ones were smooth.
In one day, Bai Ye got the results of the first part.
The mutation point was found, and the mutation results were accurate.
However, to Bai Ye's surprise, the end of this data has a result!
At the end of the first stage, the results of the data analysis are written.
This result is exactly the same as the result calculated by Bai Ye.
This embarrassed Bai Ye.
Ke Ao came back in the evening, looked at Bai Ye with a confused face, and asked what happened.
Bai Ye then said: "I calculated the result of the first part, but... I found that there is a summary of the ending below, and the other party's answer is exactly the same as what I calculated. ”
As if he knew this result, Keo frowned and asked, "Is there a problem with the analysis of the first process?"
Bai Ye shook his head: "No, there is no problem! I can guarantee the data analysis results of the first part, there are no problems, and ...... What do you want me to figure out?"
As soon as Ke Ao heard Bai Ye's words, he became a little irritable, and walked around the room without speaking.
After a long time, he said as if struggling: "You calculate the data of the second part, do the math, and be sure to pay attention to every detail to see if there are any problems." Remember...... Don't miss a clue......"
When he spoke, Bai Ye felt that Ke'ao, whose voice was a little sharp on weekdays, turned out to be a lot hoarse!
What's going on here?
Bai Ye had been thinking about this data all night.
There is no problem at all, I have calculated it back and forth, but the result is the same as that of the other party.
Even the probabilities are exactly the same!
At dawn the next day, Bai Ye and Ke Ao had a buffet breakfast together, and during the meal, Ke Ao may have not slept well last night, and his expression was a little sluggish.
Before leaving, Koo stopped talking, but turned and left.
For the rest of the time, Bai Ye didn't pay attention to the purpose of the experiment and the records of those experimental methods.
After all, the above is not detailed, just how to get a certain step, and then the data result. The core technology is simply not available.
So, it's just effortless!
Let's study the data.
In this way, the speed is significantly faster.
In three days, Bai Ye calculated the second part......
Well, no surprise, exactly the same result as the other party.
That's embarrassing......
This...... Didn't do anything by yourself?
Even if you have a bunch of results that are exactly the same as the answers?
If this is an exam, Bai Ye will definitely be happy, after all, it is exactly the same as the correct answer, why not be happy?
But this is not an exam, and looking at Keao's state, Bai Ye feels that the purpose of his calculation is definitely not to verify the correctness of this answer!
Don't...... What did he want to do differently?
Today, the lecture of Keao has ended, and everyone has a dinner in the evening to express their gratitude to the lecturers.