He is a senior MD at Cedars-Sinai Medical Center in Los Angeles, and he is currently practicing infectious diseases at Massachusetts General Hospital and Harvard Medical School.

He now spends half of his year in Los Angeles and half in Massachusetts.

He was able to provide him with more advanced academic knowledge at Massachusetts and Harvard University Hospital, but at Cedars-Sinai Medical Center in Los Angeles, he was exposed to more cases of HIV patients.

Since joining Cedars-Sinai in 1978, he has spent more than 95% of his time researching infectious diseases, and the majority of infectious disease research is HIV. It is precisely because of more than ten years of clinical research that he was able to become the creator and proposer of the first "cocktail therapy".

After all, all kinds of basic sciences, especially medicine, pay the most attention to clinical experiments. He is a doctor with a lot of clinical experience and is very popular.

So when Abel Jean George Lassman sent Amgen Pharmaceuticals president, Gordon L. When M. Binder visited in person, Dr. Ho declined Amgen's invitation. In fact, before Amgen, many pharmaceutical companies invited him, including some giants in the pharmaceutical industry, but they were all rejected by Dr. He.

He, a doctor and medical doctor with rich clinical practice experience, happens to be the sweetheart in the eyes of those pharmaceutical companies. A man like him may not be able to invent anything, but if some genius comes up with an idea, an experienced scientific talent like him can provide some advice from practical experience.

This is very helpful for medicine and medical research.

Dr. Ho declined these invitations, not because he was aloof. It's because when he first entered the medical center in 1978 and went through the clinical practice stage, he made up his mind because of some things, he must cure the HIV virus in his life!

Therefore.

As long as the company that has nothing to do with the research of the HIV virus, come and invite him to bear the fruit, the result can only be failure.

However, because the HIV virus is too difficult, it is actually not taken seriously in most commercial pharmaceutical companies. Although there is investment in research, it is better than nothing. Most of the most invested in research are those charitable foundations and government agencies.

Gordon S. M. Binder's invitation was initially rejected, but when he explained the purpose of the trip and the purpose of inviting Dr. He to Amgen, the talented Chinese medical scientist hesitated.

Gordon S. M. Binder observed the words and sent a handwritten letter from the boss of the company by the way, "Dr. Ho." Please take a look at this letter, which our boss, Mr. Sephorosa, has entrusted me to pass on to you. ”

Dr. Ho took the letter.

It was dismantled on the spot.

After watching it for a few minutes, his originally expressionless expression suddenly danced with his eyebrows.

"Huh, why didn't I think of it? Mixed therapy! It could be called cocktail therapy, it's a good idea! It's worth experimenting, but it's a hassle to have more than three effective treatments......

"Until now, there are only a few effective treatments. The effect is not very good, the HIV virus is too stubborn. ”

"Hey......"

Dr. Ho let out a long sigh.

He lifted his glasses and said to Gordon Brown. M. Binder whispered, "Maybe I can go and see it tomorrow...... Just go check it out. ”

"Okay!" M. Binder breathed a sigh of relief, anyway, Dr. Ho went, and his mission was completed. Whether or not he can stay is not his task.

…………

…………

Amgen Pharmaceuticals.

Lin Fukun and George Lasman were busy, preparing for some of the requirements to start the experiment.

And Abel.

The disguised super-medical genius who appeared to be closing his eyes and recuperating was actually looking up the information on how to treat the HIV virus and cocktail therapy in the Inquirer's Wrecking Ball.

Cocktail therapy, as you hear the name, is just a therapy. It's actually very simple, it's a mixture of three drugs that can be treated, which can reduce the resistance of the virus and achieve better results.

The advantage is that the treatment effect is very good, and it can often have an unexpected effect, but the disadvantage is also obvious, because there are more than three drugs to be used, so the treatment time is often very long, and the cost of the medicine will be very expensive if I use better drugs.

But......

Since you've been entangled in an insoluble demon like HIV, you still want to be treated. Lacking a little outside the body, I believe that all patients do not care. Because if you care about it, your life is gone, so what else is there to care about?

Cocktail therapy isn't that hard.

Basically, as long as you learn it once, most doctors can do it. It is precisely because of this inability that the inventor, Dr. He, enjoys great prestige, but it is difficult to win such a top scientific prize as the Nobel Prize.

Because it's really simple.

One of the most difficult things in cocktail therapy is the plurality of more than three effective treatments.

Until now, before the creation of antiviral protein inhibitory enzymes, cocktail therapy, or even a fantasy, was useless even if it was proposed now.

So before looking into cocktail therapy, it is important to address the issue of the drug.

Abel checked the information about AIDS in the next 30 years in the little wrecking ball, and found that although this incomprehensible disease could not be completely cured with the greatest investment of human beings, it still found many effective drugs in the past 30 years by relying on human ingenuity.

He took a look.

Some of the drugs that will work in the future have now been discovered, but they have not yet been found to be miraculous against the HIV virus. And most of them will be created in the future for the benefit of mankind.

5 major classes of therapeutic drugs.

The first major category is nucleoside reverse transcriptase inhibitors, and common drugs will include lamivudine, tenofovir, emtricitabine, zidovudine, etc. in the future.

The second class of drugs is non-nucleoside reverse enzyme inhibitors, and the commonly used drugs are efavirenz, as well as nevirapine.

The third drug is some protease inhibitors, the most common drug is Coolidge.

The fourth drug is integrase inhibitors, and the commonly used drugs are raltegravir and dolutegravir.

The fifth drug is a fusion enzyme inhibitor. Generally speaking, antiviral treatment is carried out with a dose of medicine, and the plan should be selected according to the actual situation.

There are 5 categories in total.

Cocktail therapy is actually a treatment method that selects more than three types of mixed treatment from so many drugs. The effect is much stronger than that of using it alone, but if you can win the Nobel Prize, it is indeed a little inadequate.

But......

What if the invention of cocktail therapy was accompanied by the creation of the above five categories of medicines? You know, among the above five categories of therapeutic drugs, at least five or more Nobel Prizes in medicine were born!

Abel thought.