Huntington's disease is an extremely rare autosomal dominant disease, occurring only four to five cases per 100,000 people in Europe and the United States, and less than one case per 100,000 people in East Asia. Compared with infectious diseases such as smallpox and plague, this disease seems to be unthreatening, but it is not only one of the terminal diseases that cannot be cured at this stage, but also has very strange symptoms.

There is a saying in the Celestial Empire that is very apt to describe Huntington's disease: you can't survive, you can't die.

The clinical symptoms of the disease are complex and varied, and patients have a progressive deterioration of the disease, usually dying 15 to 20 years after the onset of the disease. Patients typically present in middle age with motor, cognitive, and psychiatric symptoms. As the symptoms worsen, they will be unable to make faces involuntarily, dance with their hands, and show aggression. In the past, people thought that the phenomenon of "ghostly body" or "dependence" is actually a symptom of Huntington's disease.

The cause of Huntington's disease is that the patient's gene encoding the Huntingtin protein contains a repeating CAG triplet codon in the first exon, and the number of repeats of this triplet codon increases abnormally. Possess more than 36 CAG repeat triplets. However, if the number of repeats is 36~39, the total penetrance is low, because the number of repeats is not stable and may change when it is passed on to the next generation, so although it is a genetic disease, the patient's offspring may not necessarily show symptoms.

"She froze herself up, became an irresponsible mother, and threw such a big mess at me, not knowing that I had the same problem as her. Knowing that his mother had Huntington's disease, it was naturally impossible for Louis Lyons not to examine himself, and the result made him desperate, his symmetrical caudate nucleus was already showing signs of atrophy, "Brother, aren't you going to lend a hand to me?"

"I'm sorry, I'm just a clinical internist, and I'm not good at new drug development. Liang Baoguang is not an all-powerful god, if a patient is diagnosed with cancer, he will let the family go to the cancer center, if it is a terminal illness that does not live long, he will persuade people to enjoy the last time, "But I heard that the current gene therapy has a certain effect, and the Celestial Empire has produced some results." ”

Louis Lyons waved his hand, "I also watch Cell, but it's a pity that the things on paper are too far away." ”

"So, if you want to die anyway, you will take revenge on society?" "People who learn that they are dying will more or less show a crazy side, he has seen too much in clinical practice, and most of the high-functioning sociopaths are similarly stimulated, "I don't think it makes any sense." ”

"Then you are very wrong, I do those things only for money, and only with sufficient funds can I do the greatest work in human history. Louis Lyons stood up, walked to the very center of the laboratory, and placed his palm on a transparent pillar, "Although there is only one audience, I have no regrets that I can have my dearest brother as a witness." ”

The floor rises, and a small tube is held on a high-tech stand containing a very beautiful blue preparation. Liang Baoguang couldn't describe the feeling in his heart, he only felt that this thing was extremely evil, "You spent countless money and energy for this?"

"You should know about autophagy, right?" said Louis Lyons suddenly.

Of course, this concept has been around for a long time, and it wasn't long ago that Yoshinori Osumi won the Nobel Prize for it. "The discovery of autophagy has led to the creation of two Nobel laureates in physiology or medicine, the first being the Belgian scientist Christian de Duve in 17974 and the other being Yoshinori Ohsumi, a scientist from Region 11 in 2016. Liang Baoguang is engaged in medicine-related work, it is impossible that he has not heard of autophagy, and he has also specialized in research for a period of time.

"Whether it's Huntington's disease, Alzheimer's disease, or amyotrophic lateral sclerosis, it's actually nerve cell death caused by the abnormal folding of proteins, and as long as those abnormal proteins are eliminated, the problem will be solved. Louis Lyon holds his head proudly, and he does have the capital to do so, because the scientists all over the world who are engaged in research are just getting started, and he has already produced the finished product.

"How is it possible, you developed an autophagy agent so quickly?" If the news spreads, there will be countless people who are crazy about it, and those rich people with Alzheimer's disease are willing to go bankrupt for this small preparation, "No, if you succeed, why don't you use it yourself?"

"Because there were some small accidents, wonderful accidents. Louis Lyon's expression became self-contained, as if waiting for his brother's praise, "Autophagy is difficult to control, in order to prevent the entire system from being destroyed by autophagy, I used the genes of the lighthouse jellyfish to improve it, devouring it and repairing it at the same time." ”

"If you succeed, won't you be able to prolong your life greatly?" If it is really like Louis Lyons said, then this medicine can ensure the immortality of the human nervous system, which will greatly prolong the life of the person, because other organs can regulate it, but the nervous system cannot, and the nervous tinnitus is still a terminal disease.

"That's why it's so great, and I named it the Immortal Diamond, right. "Louis Lyons was just standing on the shoulders of giants, and without the research of his mother, Claudia Braunschweig, he would not have been able to produce the finished product so smoothly.

"There's something wrong with this medicine, otherwise Raul has used it now, and you can also thaw your mother awake. "Liang Baoguang doesn't believe that such a powerful thing can be studied so easily, Claudia Braunschweig and her mother and son are indeed geniuses, but this thing has gone beyond the scope of black technology.

"Something did go wrong, and the balance created by this drug in human trials is very easy to collapse, and you can definitely imagine the results of the collapse." Louis Lyons put the medicine into a gun syringe and handed it to Liang Baoguang, "My mother's immortality plan was originally intended for our father, so it has been based on his genes, theoretically speaking, our genes are the closest to his, so if you use it well, I can try it." ”

"You are stupid, why do you think I will be a guinea pig for you?" Liang Baoguang refused without hesitation, he never felt that eternal life was a good thing, and it was the right choice to live this life to the fullest.

"Trust me, you will. Louis Lyons laughed, "Because you have concerns, you have weaknesses that can be caught by me." ”