July 8, 2020, Baltimore, Maryland, USA.

Just 60 kilometers from the capital, Steelton, this small city, an important outlet to the Great Lakes, the Central Basin and the Atlantic Ocean, is home to a large number of blacks. The crime rate is higher than that of other cities, and the occasional fights and robberies make many people afraid to go out in the dark.

However, it is one of the world's mecca for medical practitioners, as it is home to Hopkins Hospital, one of the best hospitals in the country, and Johns Hopkins University, the first research university in the United States.

The field of medicine and public health has always been Hopkins' strength. Hopkins has the most prestigious and top-notch medical school, on par with Harvard Medical School. Since its inception, the School of Public Health has ranked first in the United States for all years.

Biology, biomedicine, biomedical engineering, etc. are ranked in the top 3 all year round. Since 2015, undergraduate biomedical and bioengineering majors have ranked first in the United States.

Hopkins is also the recipient of the largest federal grant and the National Institutes of Health (NIH) research grant.

It is here that a number of eye-catching research topics have attracted the attention of scientists from all over the world, especially biomedical scholars.

The summer sun is shining, the verdant tree trunks, countless green leaves cover the campus paths, all kinds of singing birds sing and sing endlessly, and the students in a hurry and the scholars with steady steps shuttle back and forth, full of vitality.

In the third laboratory of the Johns Hopkins University School of Medicine, the scattered experimental instruments show the brilliance of the future world, and in the center of the laboratory, several well-dressed experts and scholars stand straight, their faces full of excitement, waiting for the arrival of an exciting moment.

Professor Qu Guangquan from China nodded at his assistant.

"The last batch of test data shows that the insulin secretion mechanism of the mice has returned to normal!" said a calm and handsome associate professor, handsome as he handed out the test report that had just been printed, and his voice was still high-pitched despite being covered by a mask.

"To be precise, all the experimental mouse insulin tests have returned to normal values!" a blonde European girl held up a stack of test reports above her head.

"Professor Qu, your theory of repairing the mechanism of gene synthesis protein opening, and the vaccine developed according to your theory to restart genes to promote pancreatic cells to synthesize insulin, have now been proved to be correct in practice!" The deputy leader of the same research group from the Department of Endocrinology at Johns Hopkins Hospital was even more excited!

"Although it has only been verified in mice, it is clearly opening the door to the treatment of endocrine diseases with diabetes as a typical representative. It can be expected that we will have a smooth journey in further experiments!" added another Hopkins professor.

"Can diabetes finally be cured?" Smith, the dean of the medical school, looked at Qu Guangquan with a smile.

"Yes. Professor Qu Guangquan smiled and nodded.

"Can we apply for FDA approval?" Smith excited.

"Yes!" Qu Guangquan replied solemnly.

"Once the FDA is approved, the stage of countless diabetes drugs will automatically withdraw from the stage of history, and the vast majority of people with type 2 diabetes will not need to take drugs for life!" said another pharmaceutical expert who participated in the study.

。。。。。。

In the center of the laboratory, two hands pressed a few times in the air, and the murmur was interrupted, and after the microphone amplification, a very authoritative voice from Hopkins University sounded:

"Professor Qu, your hypothesis that the gene conversion mechanism of pancreatic α and β cell proteins, as well as the implementation of a monoclonal antibody vaccine targeted by the fat cell molecule PPAR-γ, allows PPAR-γ to bind to the DNA switch to turn on the expression of genes and restore the synthesis of insulin proteins, and now the experiment proves that this direction is correct! The principal, who came over with a tie to congratulate, smiled and hugged Qu Guangquan and congratulated the staff of the laboratory.

Applause echoed around the lab.

Qu Guangquan, whose gray hair has been dyed with sideburns, smiled slightly, "Thank you, principal, thank you, this achievement is not only my own credit, but also the crystallization of everyone's wisdom and sweat. ”

Qu Guangquan accompanied the principal and several well-known authorities, around the desk and the test bench, shaking hands with the team members, his fair-skinned, slightly tired cheeks never concealed his confidence.

Looking at the smiling faces and listening to the heartfelt praise, Qu Guangquan was full of thoughts. 50 years of long life came to mind, from the father's angry face of hating iron and steel, to the mother's reluctant hands, from the unrelenting youth, to the stumbling into the society and resolutely crossing the Pacific Ocean to the United States, as well as the irrepressible excitement of more than ten years of love with Linda, and the irrepressible excitement hit the heart.

Looking at Qu Guangquan, whose eyes were moist, a female master's student from Tsinghua University in China, communicated with the blonde girl in her ear: "Professor Qu is so handsome, if he is 20 years younger, I will definitely marry him!"

"No, you're wrong, even if I'm 20 years old, I'm going to marry him, he will be another Nobel Prize winner in medicine in our university, and the reconstruction of the opening mechanism of gene synthesis protein is no less than the DNA double helix structure theory back then!

A boy smiled and shook his head, "You also have to ask Professor Linda if you agree! Professor Qu and Professor Linda are a rare harmonious couple at Johns Hopkins University!"

The two beauties shrugged in unison.

The boy smiled and said, "Professor Qu not only showed his genius imagination in this topic, but also put forward a very forward-looking theory on the molecular initiators that inhibit tumor growth, vascular endothelial growth factor (VEGF) receptor 2 and MET!

The blonde haired and blue eyes stuck out her tongue, and the eyes of the female master of Tsinghua University were full of longing.

After all, a positive breakthrough in diabetes, the world's problem, will rewrite the course of human survival and reproduction.

This topic is destined to go down in history, and once the paper is published in an authoritative journal such as Nature, it will definitely be a global excitement.

This is definitely going to win the Nobel Prize in Medicine!

Countless media reporters have rushed to Baltimore City to report on this historic event, and Qu Guangquan will be the most eye-catching figure in the world during this time!

The president of Sanofi-Awentis?''-Deutschland-GmbH, Germany, frowned tightly, and his hand holding the mouse trembled a little.

The secretary to the president reported on the relevant situation of diabetes vaccines, and at the same time introduced Qu Guangquan's situation, and his tone was heavy.

Because Sanofi has one of the world's largest diabetes drugs – insulin glargine.

In 2011, sales reached 5.071 billion US dollars, in 2014 it exceeded 8.428 billion insulin glargine, and in 2015, it was almost 13 billion US dollars.

Even if the patent period has passed, it will take some time for generic drugs to reach the quality of Laideshi, especially the brand effect established by Laideshi, which can stand for Sanofi in diabetes drugs for decades.

Although Eli Lilly in the United States later produced its own insulin glargine, it was sued by Sanofi for 7 patent infringements, and other generic drugs did not dare to challenge the Laideshi series of barrier patents for a long time.

And just like pop songs, the first singer is always the standard singer of this song, and even if the big names come to sing it later, fans still find it as charming as the first song.

However, since the expiration of the patent period in February 2015, Sanofi has not yet obtained a new patent for diabetes drugs, and the president immediately gave the secretary a task: "If Qu Guangquan's project is not funded by the US government, no matter how much it costs, this patent must be obtained!"

At the same time, in the United States, pharmaceutical giants Pfizer, Eli Lilly and dozens of international giants also rushed to Baltimo to date Qu Guangquan as soon as possible, competing for the last pot of gold that may be diabetes drugs!

Countless diabetics are looking forward to it, as if a new world is beckoning to them.

However, on the afternoon of July 8, a piece of news from Baltimo shocked the world, especially the medical and biological communities.

After the new president who can speak Sichuan-style Mandarin took office, it caused social unrest in the United States, and the contradictions between elites and ordinary people intensified, and various protests and sabotage emerged one after another.

An anti-Prussian organization, together with a local gang of evil wolves, broke into the biology laboratory of Johns Hopkins University at gunpoint, and when they fired indiscriminately, they hit the centrifuge that was spinning rapidly next to Professor Qu, detonating the state-of-the-art fermentation tank in the laboratory, and creating an explosion that the terrorists were planning to brew, causing the spread of five unpredictable bacteria with artificial genes, killing two people and injuring nine others.

Qu Guangquan, a scientist who was celebrating in the laboratory, disappeared after the explosion!