[six]

(April 26, 2014, Sat., afternoon, Fujiwa Concert Hall, Nerima District, Tokyo)

Not long after Kaoru Miyazono fell to the ground, Sora Akiyama was the first to react, and hurriedly motioned to Akihiko Kayaba and Mitsuya Senki to call the emergency number. The latter immediately took out his mobile phone, while the former decisively rushed to the stage for first aid.

"It's a bit like anemia, but with tremors and rapid muscle spasms, it's not life-threatening for the time being. ”

Sora Akiyama was in a virtual world and could only stand and watch. At this time, the traffic situation was good, and the ambulance quickly arrived at the scene and prepared to take Kaoru Miyazono to the nearby Tozubara University Hospital.

"Are the child's families here?"

"Her family didn't come, so I'll go with you, I'll practice violin in the same classroom as her. Rinko Kamiyo took the initiative to stand up, "Chi...... Sejo-kun, please tell me her number later. ”

After the two left in the ambulance, Mitsuya Senki looked at Arima Gongsheng and asked:

"By the way, Arima-kun, do you know the number of Miyazono's family?"

Hearing Mitsuya Segi's words, Arima opened his mouth, but in the end he just shook his head. Sora Akiyama saw all of this, and the boy didn't seem to be as familiar with his accompanist as he had imagined. In the end, it was Mitsuya Senjo who got through to the head teacher's mobile phone and got the phone number of the Miyazono family from the roster in the teacher's hand.

“Moshimoshi…… Is it Mr. Miyazono?"

"Well, yes, I'm her classmate, and I'm in the concert hall now. ”

"She had just fainted and was being taken to the hospital by ambulance......"

After ending the call with Kaoru Miyazono's father, Mitsuya Senki called Rinko Kamiyo's mobile phone again and asked the other party to inform the hospital of the number. After doing all this, he condenses his clone in the virtual world and plans to go to the hospital to see how Kaoru Miyazono is doing.

"There's nothing to see if you continue here. Nanamiya Tomoon tugged at Sora Akiyama's sleeve, "Do you want to go and see how Kaoru is doing?" Anyway, the soul clone won't interfere with the doctor's work. ”

……

[seven]

(Saturday, April 26, 2014, afternoon, Tozuhara University Hospital, Tokyo)

"It doesn't seem like the first time Miyazono-chan has been hospitalized!"

Kayaba Jinghiko and the others appeared in the hospital in the state of soul clones, and it was inevitable that they would see the content on the display screen in front of the doctor.

"Moderate anemia...... Huh? This is...... Spinocerebellar disorders?"

Kayaba's eyes widened in disbelief, and then she connected to the repository of the spiritual network. It is a complex genetic disorder involving many different genes and is caused by an abnormally large number of on-chromosomal nucleotide CAGs. Since most of the CAG repeats are present on exons, there are long chains of glutamine in the proteins formed by the transcription and translation of this gene, which can cause cell death.

At first, the patient presents with a gradual incoordination of steps, accompanied by disorders in hand movements, speech, and eye movements, such as Kaoru Miyazono's current symptoms of easy falls. As the condition progresses, the patient gradually loses the ability to walk and write, and then progresses to the inability to speak, stay in bed all day, and have to be cared for by others in daily life, and finally die.

Unfortunately, there is no cure for spinocerebellar disorders, which can only alleviate the symptoms and slow down the progression, but cannot reverse the nerve damage that has been caused. Because the symptoms of atrophy are limited to the cerebellum, brainstem, and spinal cord, the patient's mental function is not affected, and the fact that the body is gradually losing its ability to move is clearly recognized, so it is a very cruel disease.

In Akihiko Kayaba's memory, Kaoru Miyazono is still the same girl in a pink dress, standing on the top of a round cumulus and playing the melodica, and the folds of her skirt flutter in the spring breeze of falling cherry blossoms. But the girl in front of her was lying on the hospital bed for infusion, her pretty face was pale and bloodless, her body trembled slightly, and a fine layer of cold sweat could be seen on her exposed skin.

His face was slightly discolored, but the reaction of his girlfriend next to him was far more intense than his.

"Seki ...... No, Mr. [Wise Man]!" Rinko Kamiyo looked at the boy sharply, "There must be a way for you, right?"

Mitsuya Sejo's face was calm, and he couldn't see any mood swings, which made Akihiko Kayaba's heart beat hard. It's not that he doesn't know the rules of the Galactic Federation, but that doesn't mean he doesn't want the other party to be able to help. Please, since you're active as a junior high school student, you can't die to your classmates, right?

"As you know, I can't cure her directly. Mitsuya Seki deliberately paused when he said this, and then turned his gaze to Xu Mingshan, "Xu Mingshan, your attention was focused on the field of molecular biology some time ago, right?"

"Yes, what's wrong?" Xu Mingshan replied with a little consternation.

Mitsuya looked around and suddenly grinned: "Listen, according to the current research of human beings, repeating amino acid sequences are very important for proteins to perform normal functions or maintain a state of non-aggregation, and the difference in the number of repeats of a certain repeat sequence may have completely different functions." When the number of amino acid repeats exceeds a certain range, more or fewer may cause protein aggregation and lead to neurodegenerative diseases. ”

"The different degrees of expression of some miRNAs can affect the average number of nucleotide repeats encoding these amino acid repeats on the intracellular mRNA, which directly leads to different proteins translated from the same mRNA. All I can say is this, and you're left violently in the mental network...... Ahem, I mean violent simulation, that's it. ”

Xu Mingshan was stunned after hearing this, and then fell into thought. As a research-trained scholar, Akihiko Kayaba is well aware of how difficult it is to do in practice—scientific researchers don't just talk about it like the middle two diseases. Something like "DNA base arrangement data is actually the source code of a certain programming language, compiled by mRNA and linked by tRNA, to become a program unit that can be run by a living system, and life itself is an abstract amplification of some kind of operating system", which is actually meaningless talk, because there is no theory that conforms to the paradigm and experimental data to support it.

"Well, in fact, Kaoru Miyazono's condition is mainly due to motor disorders, that is, spinal cord dysfunction, which is much easier to deal with than cerebellar atrophy. Sora Akiyama put forward his own opinion, "RNA drug research is a big hole, and if it really doesn't work, it is better to repair her spinal nerve with flexible fibers, or build a brain-computer-spine interface like Swiss neuroprosthetic technology." ”

In the end, the conversation did not come to a definite conclusion. In reality, they can't get involved in the treatment that Kaoru Miyazono is receiving, and the expected treatment plan is only on paper - Xu Mingshan is the only one who has time to do molecular biology, but this aspect is obviously a big hole;

For the time being, all Akihiko Kayaba can think of is to wait and see. He is currently about to graduate from graduate school, and the information integration of his graduation thesis alone is enough for him to be busy, not to mention that he is not good at the medical field as a student of physics to brain science. To his surprise, after saying goodbye to the others and returning home, his mentor, Professor Yamada, sent an email.

"Next year I will reach retirement age in Japan and prepare to go to Caltech in the United States. Do you plan to come with me or stay in Japan after you graduate school?"

……