Chapter 44: Chromosomes

"Check the chromosomes, of course you can!" Xia Linfeng looked at Su Yuan a little strangely, "Why are you suddenly interested in this?"

"It's nothing, just a little curious. ”

In fact, Su Yuan was curious about whether the chromosomes in his body were XX or XY. If it is XY, she should be entangled from a genetic point of view, because the appearance she presents now is likely to be fake, and it is not possible to say from a scientific point of view that such an unbelievable thing would happen to weishenme.

But if it's XX, at least it's the same on the outside, and there will basically be no recurrence. Although this result may make her lose hope of regaining her "male body", at least there is a certainty, and her future life will have a direction.

So as soon as he heard that the chromosomes could be checked here, Su Yuan immediately had an impulse.

"There are 23 pairs of chromosomes in the human body, of which 44 are autosomes and two are sex chromosomes. The sex chromosomes are XY for males and XX for females. In the process of reproductive inheritance, male meiosis produces X-type or Y-type germ cells, while females can only produce X-type germ cells. ”

"I know this, the male provides X or Y sperm, the female provides X eggs, and after fertilization, if it is XX, it is a girl, and XY is a boy. Therefore, in addition to the exclusivity of individual women, it is actually entirely up to the male to have a male chromosome, because the Y chromosome is only available to males. ”

Charlene nodded with a smile, "Fortunately, you are a student of biology, so it is not difficult to understand." ”

"Since you're curious about chromosomes, and I happen to be studying the subject of human genetic polymorphisms, why don't you provide some samples for my subject? Charlene proposed.

"Use my sample?" Su Yuan hesitated.

She had to be cautious about this matter, the transformation was already strange, although it could be considered that it was manipulated by aliens, but in fact, Su Yuan thought that there was something wrong with his genetics, the human body has a total of about 3 billion base pairs, nearly 100,000 genes, and so far about 25,000 genes have been found in the human genome, which is less than the expected 100,000.

But who knows if there is a gene in their genetic information that causes degeneration?

If there is, it will cause big trouble if it leaks out.

"Reluctant?" Charlene raised her eyebrows slightly, and said with a smile: "This time, in order to do the topic of genetic polymorphism, my mentor and a few senior brothers and sisters have collected more than 10,000 samples from the society. ”

Su Yuan was still not at ease, and pretended to be curious and asked, "What is the specific research on gene polymorphism?"

"To put it simply, the genes that control a trait are not static, the genetic code must be transmitted with a certain degree of accuracy and tolerance, and the genes with the same shape are not exactly the same in different groups in order to adapt to different environments. While maintaining the trait, the length of the DNA fragment can be different, the DNA repeats can be different, and the scattered individual bases can also be different. ”

"For example, the genes that control single eyelid and double eyelids, even if they are all expressed as single eyelid genes, these genes can not be identical. ”

Su Yuan nodded and said: "I probably understand, that is, the useful information carried by a gene is the same, and the regions in the long string of DNA that do not code for proteins or do not have important functions, these non-expressed parts are not exactly the same due to genetic mutations due to environmental factors." ”

"That's pretty much it. Charlene gave her a teachable look, "These variations could be changes in the 'restriction enzyme' site caused by the deletion, duplication, and insertion of a single baseβ€”which leads to a change in DNA length, or a variation in the copy number of the repeating sequence, or a scattered deletion, insertion, or substitution of a single base." ”

"Our task is to study the distribution of the three conditions that cause gene polymorphisms. ”

"Is that picking specific genes for comparison?" asked Su Yuan.

"That's right. We mainly selected three genes that control single eyelids and double eyelids, genes that control hair color, and genes that have or do not have earlobes. ”

"I thought it was a check for all the genes!" Su Yuan breathed a sigh of relief.

Charlene patted her on the shoulder and said with a smile: "Check all the genes, you think we are the human genome, it took several years for several countries to work together." Even if our research group only selects three genes for research, we need to divide the personnel into three groups to work at the same time, and the workload is quite huge. ”

"I didn't know at first!"

Su Yuan was also a little dumbfounded at this time. Human genes are so complex, and it is a bit ironic to select only three specific genes for polymorphism analysis to be a very large system engineering, and it is a bit ironic that I am worried that unknown genes may be exposed.

Genes cannot be easily observed with the naked eye, and Charlene's task is only to select three genes for observation, and there is no trace of other genes other than these three genes.

Even if the layman doesn't understand, he actually began to worry about the sky.

"You were curious about chromosomes just now, right, if you provide a sample, sister, I can let you see your chromosomes!"

"Wouldn't this be troublesome?" Su Yuan thought that Xia Linfeng's research was already so heavy, would her "curiosity" increase her workload?

"Don't worry, it's just a little thing in passing. ”

Hearing her say this, Su Yuan did not refuse.

Seeing this, Charlene moved a special laboratory chair and tiptoed to take out a disposable lancet and two blood sample test tubes from the cabinet above.

Seeing the blood collection needle and the two test tubes containing blood samples, Su Yuan's eyes turned green all of a sudden, and he stammered, "It's still ...... Do you need to have blood drawn?"

"How do you get genes without blood drawing? Come, roll up your sleeves. ”

"I thought I could just use epidermal cells and oral cells. Su Yuan muttered, but rolled up his sleeves very obediently.

She was wearing a lilac long-sleeved casual shirt, which was hard for her on such a hot day, no wonder she always ran to the air-conditioned library.

"For the experiment, we chose peripheral blood. ”

The long sleeves were rolled up, revealing fair and tender skin, Xia Lin glanced at it and exclaimed, "Su Yuan, your skin is so white." ”

Su Yuan smiled and closed his eyes, "Smoke." ”

He tied the rubber sleeve and gently patted the crook of his lower arm, and the sharp needle leaned over.

Su Yuan suddenly opened his eyes, "Slow!Sister Xia, are you not skilled in blood drawing, can you succeed at one time?"

Xia Linfang suddenly said in annoyance: "Don't you know that sister, I used to be a medical university! Isn't it trivial to draw blood? Your arm is so white, and your blood vessels are quite clear, so you can guarantee success at one time!"

"Oh. Feeling only a small pain from a needle, Su Yuan opened his eyes and saw bright red blood flowing out of the blood collection needle, and soon filled two blood sample test tubes.

"It's done. ”

"What should I do next?" Holding the disinfectant cotton ball in one hand, Su Yuan followed closely behind Xia Linfeng.

"Let's culture the cells. Each chromosome can be seen as a double helix of DNA molecules circling and shrinking together, and in order to see more clearly, a large number of dividing cells need to be obtained. ”

Su Yuan nodded.

She understands that after all, the blood taken has a large number of red blood cells, and red blood cells have no genetic characteristics, and there is no DNA, and through culture, a large number of other cells with genetic characteristics in the blood can be obtained.

"How long will it take?"

Charlene thought about it for a moment and said, "Three days." Dividing cells can be observed by incubating cells at 37 degrees Celsius for three days with the cell growth stimulating factor 'plant lectin'. ”

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