At noon the next day, Jiro Matsukawa's death was finally noticed by the hotel, and the panicked hotel manager immediately reported the case, which was revealed in the media not long after. Pen % fun % Pavilion www.biquge.info

Since this guy is a foreign citizen, and his identity is more important, the relevant parties still attach great importance to it, and immediately took out his capable forces to go to the hotel to investigate.

Finally, after several senior forensic examiners, it was believed that this guy died of acute cerebrovascular embolism, ruling out the suspicion of premeditated murder.

The Consulate General of Fuso was not satisfied with the results, but it did not say much in the absence of evidence, so it asked the forensic experts of the country to come and see it again.

The Huaguo police had no objection to this, so they temporarily kept the man's body in a Japanese-funded charity hospital and waited for the arrival of experts from Fuso to conduct a joint examination.

As for Liu Yuerong, he was also admitted to the hospital because of alcohol poisoning, and after a period of rescue, he lost his breath inexplicably, although he was not drunk last night, but according to the experience of the forensic doctor, there are also autopsy results, which show that he did die of alcohol poisoning, and there is no other reason.

After listening to the report of the mother emperor, Zhao Xinglan no longer cared about this matter, anyway, the split had been evacuated safely, and no matter how those guys tossed in the future, it had nothing to do with him.

On the first day of December, the Mother Empress officially began to transform, and this is also the time when it is at its most vulnerable.

Therefore, under Zhao Xinglan's order, the split corps throughout the western Pacific suspended all tasks, all retreated, and laid a number of tight defensive lines along the perimeter of the Mariana Trench to ensure that the transformation process was foolproof.

As for herself, after arranging the company's affairs, she moved directly into the laboratory with a set of suits for a temporary stay, for the reason that it was ready-made: to step up the research and development of new drugs.

This kind of state-level laboratory is heavily guarded, and ordinary spies and killers don't even want to get involved, and it's actually quite safe to live here.

Moreover, after Xie Xuan learned of this, he silently informed the relevant parties, raised the vigilance level of the laboratory to the highest level, and arranged for Li Ruomei to lead a female bodyguard to guard day and night.

“…… Lan Lan, why are there only fifteen test potions this time, I feel like there are fewer of them!"

In the closed confidential test area that has undergone strict disinfection, Yu Menghua and Xie Xuan, who are wearing masks and tightly wrapped in protective clothing, are watching Zhao Xinglan busy, and when they see her carefully taking out a box from the safe, they can't help but ask.

Under the lid of the transparent plexiglass box, fifteen finger-sized crystal glass test tubes were neatly arranged, and the medicinal liquid inside glowed with a faint golden glow under the light.

"Because it's so hard to refine,"

Zhao Xinglan replied: "You may not know, just these fifteen test potions are obtained after hundreds of failures, wasting tens of tons of high-grade culture liquid, as well as all kinds of expensive raw materials, it makes people feel heartbroken to think about it." ”

"Uh, how much is that?"

Yu Menghua asked puzzledly, she was a layman in this regard, so she didn't know the cost of this potion, but the price that made Zhao Xinglan feel pain must not be a small amount.

"The entire R&D and refining cost of these fifteen genetic elixirs is basically the same as the cost of a Ford-class aircraft carrier in the United States!" Zhao Xinglan's words made the two beauties instantly petrified.

The Ford-class aircraft carrier is the largest tonnage and the most advanced aircraft carrier in the world, using revolutionary electromagnetic catapult and a series of other high-precision technologies, and its comprehensive combat power is proud of the world, and it is a veritable national weapon.

The cost of developing these fifteen genetic potions can be compared to such a supership, which is really a bit beyond their expectations.

"This ...... Is what you said true?" Yu Menghua asked again in disbelief, and only after receiving an affirmative answer did he finally believe that he had heard correctly.

"I think it's a reasonable price,"

Xie Xuan smiled indifferently: "Compared to its excellent efficacy, tens of billions of dollars should be very cost-effective, anyway, there are definitely a lot of rich people who are willing to pay for it in the future, isn't it?"

Zhao Xinglan nodded slightly, outsiders may find it unimaginable, but the cost of research and development of a brand-new drug is definitely an amazing number.

Exactly how much it costs to develop a new drug has been a topic of international debate for many years. Depending on the calculation model, experts can give very different results, ranging from as little as $500 million to nearly $5 billion estimated by Forbes. The most frequently cited figure is that published in 2003 by Tufts (Center for International Drug Development and Research): $802 million.

However, in recent years, the development of new drugs has become more and more difficult, and the development cost has also risen significantly. This is not only because of inflation, but also because the technical threshold of the pharmaceutical regulatory department is getting higher and higher. For example, since 2000, blood indicators have gradually become auxiliary data for clinical development, and the improvement of clinical indicators has increasingly become a necessary condition for the marketing of new drugs, which has greatly increased the development cost.

So Tufts later gave the latest data: the average cost of developing a new drug by an international pharmaceutical giant is about $2.6 billion, including $1.4 billion in R&D expenses and $1.2 billion in investment losses over the same period. But it does not count the average after-sales expenses of $312 million per drug.

Tufts' analysis comes from 106 R&D projects at 10 major pharmaceutical companies. Pharmaceutical companies are of different sizes but reasonably distributed, accounting for 35% of the sales and R&D investment of the world's top 50 pharmaceutical companies. The compound must be a self-developed project and enter the clinic within the year. And all expenses are converted to the same monetary value in 2013 based on inflation.

This statistic, probably the most complex and reasonable of the known calculation models, basically reflects the average cost of developing a new drug over the course of a year. Of course, the development cost of each specific compound will vary greatly depending on the manufacturer, indication, molecular target, whether it is the original research or me-too, etc., but this data at least gives drug workers a rough reference range of "how much it costs to develop a new drug".

Of course, the domestic price level and human resource costs in China will not be comparable to those in foreign countries, so the cost of new drug research and development is usually much lower, but it also depends on the specific situation.

Xie Xuan's statement is not wrong at all, when the temptation to extend his life span by ten years is in front of him, the world's top rich people will go crazy for it, and when the time comes, the super local tyrants who are waving large checks and competing to come to the door will definitely squeeze through the reception hall of Xinglan Group!

After all, in the face of the threat of death, no amount of wealth is just a floating cloud, and death cannot take away a penny and a half. So when encountering such a chance to continue his life, as long as he is not a super miser like Grande, he will not refuse to pay a huge bill for this new drug.

Under the personal witness of Zhao Xinglan and the two daughters, the two assistants injected the fifteen precious drugs into the fifteen test mice, and the next thing was patient observation and data collection.

"By the way, what is the expected output of the new drug in the future?" Xie Xuan suddenly remembered this important question.

"Thirty a month, that's still an optimistic estimate. Zhao Xinglan replied.

“……”