Cholera was introduced to China, using the traditional name of cholera. As early as in the Neijing, the name cholera was used many times. For example, the chapter "Lingshu Five Chaos" says: "If it is chaotic in the stomach and intestines, it is cholera." "Su Wen • The Great Theory of Qi Alternation" said: "The land is not in time, and the people are sick and cholera." "Su Wen • The Great Treatise of the Six Yuan Zheng Era" says: "Taiyin is full of cholera and vomits." The Book of Han says: "In the summer and summer of Fujian, the diseases of European (vomiting) and cholera are also accompanied by them."

The "Treatise on Typhoid Fever" has a relatively systematic explanation of the symptoms and treatment of cholera, such as "vomiting and benefit, this name cholera", which shows that cholera was already a well-known disease name in the Han Dynasty.

As for the cholera caused by Vibrio cholerae, scholars mostly follow Wu Liande's discussion in "Introduction to Cholera", which believes that it was introduced to China in 1820, the 25th year of Jiaqing in the Qing Dynasty. He is based on what Song Rulin said in the preface to the republication of Lin Sen's "The Complete Book of Sha Disease": "In the autumn of Jiaqing Gengchen (1820), many people vomited and diarrhea, and the following year Xin Si was even more dramatic." Youyun: "This disease began in Guangdong, and this year in Fujian and Taiwan, especially the patients." Yu Yunxiu researched in the article "Cholera Epidemic and Old Chinese Medicine" that there was cholera in China, which was introduced from India by land around 1817, and although it was recorded before, it could not be determined that it was real cholera. There are two views in the academic community, one is that the introduction of 1817 did not cause a special pandemic, and it can be omitted. Another view is that cholera was introduced to China in 1817 when the pandemic was caused by India, so the first introduction should be counted from 1817. Japan's Imura also supports Yu's views. For cholera, there seem to be earlier records in our country, such as the 35th year of Wanli in the Ming Dynasty (1607) Tu Shen's book "Hundred Generations of Medical Sects" recorded that "Jiajing Jiazi (1564), many people suffer from this disease, from the heart of the feet to the knees, there are countless people, and tens of millions of people died." Later generations of doctors gave cholera the name "pomescle" based on this. Medical historian Chen Bangxian believes that Wang Tao of the Tang Dynasty described the symptoms of cholera in the "Secret of Waitai" as vomiting, abdominal pain, cold hands and feet, irritability, retching, and tendons, and seems to have known this disease.

In the seven cholera epidemics in the world, China has been a severely affected area in each case, and in the interval between the two epidemics, there have been many patients and many people have died. According to Wu Liande's "A Brief History of Cholera Epidemic in China and Its Ancient Remedies", it is recorded: "Since 1820, when the British used troops in Burma, once the cholera epidemic occurred, it went straight from the sea route through Burma to Guangzhou, and spread to Wenzhou and Ningbo, with Ningbo as the drama. The following year, true cholera spread from Ningbo to other ports in China, reaching Beiping, Zhili, Shandong and other provinces. It was introduced to China from India in the summer of 1826. In 1840, the Anglo-Indian forces were transferred from India to the Anglo-Indian forces, resulting in a third cholera epidemic." Lu Dingpu said in "Lenglu Medical Words, Volume 3, Cholera Turning Tendons": "After the year of Jiaqing Gengchen (1820), there were many patients." Wang Qingren also said in "Medical Forest Correction Mistakes, Volume II, Plague and Poison Tu Di and Turn Tendon Theory": "In the first year of Daoguang Xin Si (1821), the number of people who were sick and vomited and diarrhea turned tendons in several provinces, died too much, and those who were poor and could not be buried, the state issued coins and coffins, and a total of hundreds of thousands of gold were given in the remaining months." In the Qing Dynasty, it was most popular in the tenth year of Guangxu (1888). In the era of the Republic of China, cholera was the most widespread in the 21st year of the Republic of China (1932), affecting 306 cities, with 10,666 sick people and 31,974 deaths.

After cholera was introduced to our country, because the source of the disease was unknown, doctors named the disease according to the symptoms and prevented it. Xu Zimo called this disease "Hanging Foot Sha" in "Hanging Foot Sha", and the same book called it "Ma Foot Plague" with the title, and Tian Jinyuan called it "Shi Xing Cholera" in his book "Shi Xing Cholera Refers to the Mystery". In the early years of the Republic of China, there were also English speakers who called the disease "true cholera". Since then, with the development of the times, after the middle of the twentieth century, the disease has been called cholera in statutory literature and textbooks, and it is no longer called "true cholera" and other names. In Wang Mengying's "Treatise on Cholera", it is proposed that in spring and summer, alum and realgar should be poured into the well, and the water tank should be soaked in kudzu root and incense as the method of disinfection prevention.

Although the source and severity of cholera are different from those in the Treatise on Typhoid Fever, the use of syndrome differentiation and prescriptions in the Treatise on Typhoid Fever, such as the use of Lizhong Tang and Siyi Tang, can receive good curative effects. Xu Zimo clearly pointed out in the "Treatise on Hanging Foot Sha" that the medicine of warm meridians and yang is the cure. Although Xu Lingti, Wang Mengying and others have opposed this point of view over the ages, saying that cholera is a fever and cannot be treated with hot medicine, but from the perspective of the cold symptoms such as abdominal pain, rice swill, and cold hands and feet, it is suitable to use ginger attached to the four adversaries, which is also verified by practice. At that time, Mr. Zhang Taiyan pointed out that the curative effect of Siyi decoction is comparable to that of camphor acupuncture and saline injection (rehydration) in Western medicine, and the principle is also the same. In modern times, the main principles of cholera treatment are nothing more than infusion or oral medication to replace water and electrolytes, antibiotics (eg, sulfonamides, furazolidone, tetracycline, doxycycline, etc.) to treat complications and symptomatic treatment. The use of traditional Chinese medicine in the treatment of cholera is worth paying attention to, as early as the Neijing Doctrine of Luck, it was pointed out that different types of climate patterns are associated with the prevalence of certain diseases. In 1951, Yu Wei's research on the cholera epidemic in Shanghai in 1946~1950 confirmed that the cholera epidemic was related to the absolute humidity of the atmosphere.

The Elto cholera outbreak in 1961 also appeared in the coastal area of Guangdong Province in China, and later affected more than 20 provinces and municipalities (autonomous regions and municipalities directly under the central government). Cause a certain amount of harm. The cholera epidemic in India and Bangladesh in 1992 has been confirmed to be caused by a variant of the Eto-type, which was named 0139. It has now spread to Pakistan, Sri Lanka, Thailand, Nepal, Hong Kong, Europe and the United States, China first found 0139 in Xinjiang in 1993, and more than 300 cases were reported in more than 5 years, accounting for only 0.5% of the cases in Alto in the same period. At present, cholera epidemics in developing countries remain a troubling public problem. In 1997, a massive cholera outbreak among Rwandan refugees in Zaire infected 70,000 people and killed 12,000. This proves that cholera is still catastrophic and that the seventh epidemic is not over.