Because of the tight time and heavy tasks, the building of the Clinical Trial Center of Hedong University used the ready-made building of the School of Science.

The building, which was originally intended for teaching students in the Faculty of Science and was partly used as a classroom for teachers, is now occupied...... Everyone is actually still very happy.

After all, there is a new project landed, and for all the teachers and students of Hedong University, it is a great thing that Yang Rui's clinical trial center is located in this school, no matter how you look at it, especially for the teachers and students who are studying there, and they are extremely looking forward to it.

The current distribution system determines that the school's forced grade is more important than the quality of teaching.

A good school will have a good unit to ask for people, and a bad school will connect with a unit that no one goes to, a very pure working relationship, and occasionally there will be a little bit of a leak, but for the vast majority of students, it is really a matter of serving everyone to win glory for the school.

The school's forced qualifications are not enough, and other units will not recruit people at all, what do you say about your quality, how is this year's genius, and do the leaders of government units and state-owned enterprises care?

A provincial enterprise will be very proud that it has grabbed a student from Peking University and two students from Beijing Institute of Technology this year, but it will be very shy to say that we have solved the work of 12 children of secondary school in this unit, of course, it is solved under a very strict audit system......

Even if you enter the unit, the university where the first degree is located will still be mentioned on different occasions, and it will play a big role from time to time. Especially in vertical systems, such as electric power, postal services, telecommunications, taxation, railways, water conservancy and other departments, at the provincial, municipal and national levels, there is basically a mainstream school preference, which will change differently in different periods of time and different periods of time, but it is real.

For example, this kind of first and only clinical trial center in the country is located in Hedong University, and all the enterprises and institutions related to biology, zoology and pharmacy in the country will definitely pay more attention to Hedong University when selecting people this year.

Even the units of the hospital, health bureau and other systems, when they pick people, they will also look up to the students of Hedong University.

The so-called edification, smoked out of vinegar, and smoked out of Nobel laureates, should be treated differently.

For the students of Hedong University, a building of the Faculty of Science is really not so charming.

Not to mention, construction is still intensifying next to it, and a new building is being built.

The excitement of students and faculty can also prove that everyone is actively applying to join the clinical trial.

It's not for a subsidy of two cents a meal a few days - the most taboo thing in clinical trials is to lure people to participate in the experiment with money, which is different from what ordinary people think.

That is, the first phase of the clinical experiment, the subsidy is slightly more, because it is necessary to use healthy people to do safety tests, but it is just a little more, far from enough to attract people to actively participate - European and American pharmaceutical companies will give some medical insurance for a slightly longer period of time in disguise, so as to have a certain attraction to low-income groups, but the gray area will end here, and further on, it is basically an illegal part, once it is discovered, the experimental results will be heavily doubted.

The students and faculty of Hedong University are not because of subsidies and non-existent medical insurance, but because of their positivity, in the final analysis, can be attributed to dedication.

Or rather, a kind of hero complex.

In this era, heroes are still the pursuit of most people, at least, the deep-seated pursuit of most people's hearts.

Students, faculty and staff in ivory towers have even more of this tradition.

The first phase of the experiment was repeated, so it also went quite smoothly.

It originally only needed dozens of people to participate, and the core of concern was safety and pharmacokinetics - simply put, what was excreted was excreted, whether it would generate additional toxic clouds in the body, and the most troublesome part was to recruit volunteers, analyze something, and pull a few skilled experimental dogs to do it, not to mention, Pfizer has completed a phase I clinical trial.

Yang Rui did repeated experiments, mainly to verify them, so as not to be deliberately deceived by Pfizer, so that he bought a fake.

It is also one of the effects to get off to a good start and let everyone get acquainted with the equipment and instruments, and it is not even necessary to follow the steps of the first phase completely. To apply for a license in any country, there is no need to do two clinical phases, and one hundred and fifty ten, not to mention anything else, it is less to waste millions in vain.

After a short process, the high-profile phase II clinical trial was put on the table.

This time, the building of the Clinical Trial Center was fully utilized.

The focus of the phase II clinical trial is divided into two points, the first focus is still safety, what should be done in the first phase, and the second phase should not only be done, but also expanded.

The second concern is efficacy.

From the screening of compounds to animal experiments, to the first phase of clinical trials, and then to the second phase of clinical trials, the previous part, to say that the focus on efficacy is also concerned, but no experiments have been carried out on humans, and now, it is finally time to test and harvest.

For this reason, Huang Mao made a special trip from Sinovel Laboratory to be responsible for the coordination of the experimental work.

Tu Xian and his wife Wang Xiaoyun also went to Pingjiang on a business trip to help, sildenafil is a drug bought in the name of Yang Rui, and its rights and debts also belong to Yang Rui, so he naturally can't let the ion channel laboratory or Yang Rui's genetic engineers come to help. In fact, it's okay to go to them to help, but Yang Rui doesn't think it's necessary.

The most needed doctor in the clinical trial center is still the doctor, it does not even need a permanent research team, whoever is willing to test the drug can rent the experimental center, and changing a research team will not affect the accuracy of the experiment.

Of course, for the sake of insurance, the newly built clinical trial center of Hedong University still needs a permanent team, and Yang Rui entrusted Li Zhangzhen to hire a few doctors, and he pulled a few pharmacokinetic scholars himself, even if it was to form a research team of the clinical trial center.

That is, he is now very prestigious, otherwise, investors would have to be angry when they see him doing this.

No matter how much money is spent, the research team is organized, and it is organized so casually.

The other is because of Yang Rui's lack of confidence.

If you don't have enough faith, don't buy sildenafil, how expensive is this?

It's really a cub who sells Yetian and doesn't feel distressed.

The bank cadres of the four major banks are all distressed.

Yang Rui still commanded everyone to do things with a flat attitude.

He said that he was in charge, but in fact, he was also discussed.

He has never done clinical trials before, but several pharmacokinetic scholars, at least all have experience in the development of Chinese patent medicines, combined with some public information, but also learn decently.

The difficulty of clinical trials is fundamentally the same.

In later generations, there were many clinical trial centers in Africa, and in places like Uganda, how many qualified doctors could there be?

People make anti-malarial drugs, HIV drugs and the like, and they are doing the same.

It's just that in the eyes of the bankers, this is too child's play.

The vice president who came to inspect heard about Yang Rui's prestige, and he didn't want to offend him easily, so he instructed his manager to inquire.

"What are the criteria for a phase II clinical trial?"

"What do you expect its depressurizing capacity to look like?"

"How sure are we of passing the phase II clinical trial?"

The manager had a lot of questions, but not many could be answered by Yang Rui.

Several vice presidents of banks had to look at the snow-white ward day by day, as well as at the conference room, a few large blackboards full of words in a daze.

What is on the blackboard, they can't read.

What is in the ward, they still can't understand.

It's useless to understand it, or rather, it's just to add to your troubles.

Through discussion after the meal, several people basically made it clear that Yang Rui was suspected of cheating money, but they were always unsure why he did this.

"Professor Yang, what's the result today?" It was another evening, and Wang Xiaoshu from ICBC was chasing Yang Rui's steps out of the house, tired from both sides.

"Oh, and the results today weren't so good. Yang Rui made a slight smile and showed it to those who didn't know, just as he was calm and super resistant to pressure.

Wang Xiaoshu was not in the mood to laugh today, he smiled stunned, and said: "The result is still not good, aren't you in a hurry? Also, hundreds of millions of dollars of expenses are not spent on your money." ”

"It's not my money that's spent. Yang Rui was not happy, and said: "What your bank took out is a loan, not a gift to me, what's the matter? You want to erase the debt for me?"

"I guess that's it!" Wang Xiaoshu jumped up suddenly, not like a sixty-year-old cadre, and shouted: "You want to use our money for pharmaceutical development, you are too ruthless, do you know what the concept of 180 million US dollars is? That's how much people's hard-earned money, you just robbed it...... I, I'm also about to retire, I'm not afraid of you, I'm going to report to the top and stop this matter!"

"Stop?" Yang Rui shook his head and said, "Don't be kidding, you are just the bank that pays the money on behalf of you, and the matter of pharmaceutical development is not your specialty." ”

"Pharmaceutical development is always Pfizer's specialty, I don't believe that Pfizer didn't do the second phase of clinical trials, they must have secretly done the second phase, and the performance was not good, so they sold it to you. I don't understand pharmaceutical development, but I understand acquisition transactions, and a fool can sell drugs to you like this, a big deal of hundreds of millions of dollars, can you be so casual? That is, you young people dare to do this. ”

What Wang Xiaoshu said made Yang Rui impressed.

It is very interesting to be able to say that Pfizer may have secretly done the second phase of the clinical trial.

Unlike many Chinese nowadays, they will think that foreigners are very well-behaved.

Pharmaceutical companies are in the business of human life, okay, abide by your sister's rules.

It is indeed difficult to secretly do clinical experiments, but it is difficult not to say that it cannot be done.

It is true that Pfizer cannot openly do phase II clinical trials, but it is still very possible to do a small-scale efficacy study in private.

Of course, this kind of small-scale testing often does not fully grasp the situation of the drug, and it is likely that there will be omissions, but Pfizer makes up for the omissions with expensive contracts.

Therefore, although Yang Rui does not know whether Pfizer has done phase II clinical trials, Wang Xiaoshu's guess is very reasonable.

It is likely that Pfizer decided to sell sildenafil to Yang Rui after not seeing good efficacy in a small-scale test.

At the very least, they did a certain amount of testing and judgment before selling.

In terms of antihypertensive effects alone, Pfizer's case for selling sildenafil is already abundant.

Wang Xiaoshu's guess is also very reasonable.

Unfortunately, he doesn't have the power to decide.

Yang Rui said: "I can't explain to you about scientific research, you obviously don't know much about the field of medicine. In short, I don't care if you believe it or not, but if you affect my research, you're welcome. ”

"It's useless for you to be polite to me. I know that you are Professor Yang, but let me tell you, the four banks have already negotiated it, and if you don't give a reasonable explanation, we will freeze your money if necessary. "Wang Xiaoshu seems to be aggressive, but he is actually very weak-hearted. To say that his level is already very high, let alone a small research institute, even the central enterprises dare not despise him.

However, when he spoke, Comrade Wang Xiaoshu still gave enough way out, and while wooing the other three banks, he said a reasonable explanation and necessary circumstances......

Yang Rui looked behind him, shook his head, and said, "What about the representatives of the other three banks?"

"I'll just say it. Wang Xiaoshu was also a little embarrassed, among the four, he was the oldest, the closest to retirement, and had the strongest sense of justice. Other people's attitudes should be said to be incompatible, acquiescing behind them, and it's still uncertain what will happen in person.

Yang Rui guessed the reason, and smiled disdainfully: "Let me say so." ”

"I'm listening. Wang Xiaoshu concentrated.

Yang Rui said "En", and raised his voice a little to ensure that he could hear anyone hiding around: "Which bank is the first to find trouble, and which bank's debts will be paid off last, do you hear clearly?"

Regardless of whether it is 180 million or 580 million US dollars, the four banks all contribute capital proportionally, but when it comes to repayment, can they repay hundreds of millions of dollars in one go?

Of course it's impossible, even if the new drug is sold in one go, the other party may pay in batches, and maybe it will use shares to deduct cash or something. Not to mention the sales collection, it always has to be one after another.

If you can't sell it, it's even more doomed, and the money for repayment is not enough, so who will you give it to first and then to whom?

If it is executed in accordance with the law, the debt is paid in order.

However, no matter how strict the law is, there is room for action, not to mention, here are the non-standard debts of the four major banks and Yang Rui.

When it came time to give money, Yang Rui didn't give the money according to the proportion, or the money was paid back in order, who could do anything?

Wang Xiaoshu seemed to have been hit in the chest with a heavy hammer, and his blood pressure soared in an instant.

"Okay, go back and have a good rest, and I'll show you the specific situation tomorrow, so that you can learn more about clinical trials. Yang Rui was also afraid of being angry with the old cadre, so he smiled and eased the scene and gave Wang Xiaoshu a step down.

"I'm going to bring the experts. Wang Xiaoshu blushed and took the opportunity to make a request.

"No problem. Yang Rui nodded in agreement, he was very confident in the effect of sildenafil on lowering blood pressure...... The results should be fairly stable.

(End of chapter)