"Let me start by talking about the current state of development of medicine and biology at home and abroad. The pen %fun %Pavilion www.biquge.info explain it clearly in a few words. Yang Rui thought for a moment and said: "In short, since the 70s, it has been the golden age of new drug research and development in the world, and a series of original drugs and imitation innovative drugs have been marketed successively, and the first of the synthetic β adrenergic blockers propranolol, histamine H2 receptor blockers cimetidine and ranitidine are the first cases, saving many patients and making high profits. As a result, nearly 20 years of development of new drug research theories, as well as the rapid development of various technical platforms and methods, China has not kept up with the times at all. ”

Yang Rui glanced at the three of them and saw that they were indeed listening, so he continued: "For now, our backwardness in new drug research cannot be changed in a short period of time, and the reason is very simple, our country has no money. At present, the investment in new drug research and development is about $400 million per drug, but this number will skyrocket, and I expect that by the end of the 80s, the capital cost of a new drug will rise to $1 billion to $1.5 billion, and the R&D cycle will increase to 10 to 12 years......"

Yang Rui didn't care about making a prediction, but he didn't know that this kind of prediction rarely appeared when giving lectures to the bigwigs - it's okay if you guess right, but if you guess wrong, it's over.

Yang Rui was not afraid of these, and unscrupulously talked about many problems in drug research and development, and spread out to the domestic biopharmaceutical industry.

He was so familiar with these contents that he didn't need to think much about it to be accurate and detailed.

The three listeners also listened very carefully, saying that the pharmaceutical industry is one of the few high-tech industries in China that can earn foreign exchange -- although it is very high-tech compared to the international level, it is still a very important industry after all, and it is naturally necessary to learn about it in two hours.

Tang Gong even took out a notebook to make a brief record, and when Yang Rui paused, he asked, "Yang Rui, I heard that you have made a new medicine, which has been sold to foreigners, and it is very valuable?"

Yang Rui did not shy away from saying: "Yes, I signed a milestone contract, and the total value of the contract is more than 10 million US dollars." ”

The three bigwigs looked at each other, and none of them asked where the money went.

On the contrary, Tang Gong asked with interest: "Is it possible to develop such a drug in China?"

Yang Rui thought for a moment and said, "Although I don't want to say it, I think it's unlikely." ”

"Huh?"

"New drug research and development is a probabilistic problem, for now, the cost budget for developing a new compound is $50 million, of course, $5 million may be done, but $5 million may also get nothing, so in order not to lose money, a budget of $50 million needs to be prepared. Yang Rui paused for a moment, and said: "The domestic budget cost may be a little higher, after all, there is no equipment or anything, and you have to buy all new ones." I'm just talking about making new compounds, like I've done before, and if you do a full drug development, it's longer, it's less efficient, it's less realistic. ”

"So, domestic pharmaceutical companies can't make original drugs?" Tang Gong looked a little regretful, probably the kind of person who can't see the loss of profits.

After thinking for a while, Yang Rui said: "I am in favor of making generic drugs first, and then making original drugs, but the goal of making generic drugs should be to make original drugs, not just imitate them all the way." ”

Yang Rui paused and said: "Intellectual property rights and patent protection are the basis for the research and development of new drugs, otherwise, no company would use $1 billion to make a wedding dress for people." ”

When he said this, he naturally thought of the history of generic drugs in India. In later generations, India has become a pure generic drug country, and their national policy requires pharmaceutical companies to force authorization, of course, the current India, this system and regulations are not perfect.

So, Yang Rui once again in the form of prediction, said: "There is a fundamental difference between the development of the generic drug industry with the goal of original drugs and the generic drug industry with the goal of developing generic drugs......

Immediately afterwards, Yang Rui said the policy that India will implement, and said: "I estimate that India's generic drug industry can be bigger." However, after all, the production of generic drugs must be limited to original drugs, and the change of policy, and even the change of international form, will affect their industry, which is not very suitable for China to learn. ”

What the three bigwigs want to hear is naturally the content at the national level, and Yang Rui's answer is also very attractive.

The pharmaceutical industry is a trillion-dollar industry in the world, and it is one of the largest industries, and its consumption of resources is very small, and it belongs to a category of extremely high added value.

"So, if we want to develop original drugs in China, do you think it is feasible?" Tang Gong asked about the specific steps, which is already the level of policy consultation.

Yang Rui thought seriously for a moment and said, "Overall, I think that the four or five five-year plans should be able to see results. However, the cost of drug research and development is so high, it is still necessary to take enterprises as the main body and fully consider the benefits, otherwise, no matter how rich the country's finances are, they will not be able to support such a long and huge investment. For now, I think GMP is a good strategy. ”

"GMP stands for Good Manufacturing Practice?"

"Yes, GMP is not an end, but a means, and the main problem of domestic pharmaceutical companies is still too much. Whether it is the experience of the United States, the experience of Japan, or the experience of Northern Europe, pharmaceutical companies are bigger and stronger, mergers and acquisitions are also an inevitable way, there are currently more than 4,000 pharmaceutical companies in China, there are too many, and the generic drugs of generic drugs are uneven, and the development of original drugs is ......" Yang Rui laughed twice, then shook his head, and said endlessly: "I think that it is a lot for domestic pharmaceutical companies to keep around 100, and in the short term, it is necessary to control the scale of pharmaceutical companies at 1,000." ”

Historically, the implementation of the GMP system has reduced the number of pharmaceutical companies in China from 4,000 to 2,000, and Yang Rui's attitude is naturally more resolute and radical. In the case of the government's public power to provide raw material guarantee and the governmentization of drug procurement, it can also generate losses, not to mention the value, such pharmaceutical companies produce fake and shoddy products, but patients have no choice and right to resist.

The three bigwigs couldn't help but fall into deep thought, Qiao Gong was even more suddenly spiritual, he was in favor of large-scale mergers and acquisitions of domestic enterprises, starting from pharmaceutical companies, it was the incentive to have a law and Boding, if it was because of this, the whole industry could be shut down and transferred, which was naturally more in line with his governance philosophy.

Tang Gong and Li Lao's governance concepts are more peaceful, but Yang Rui's statement has shaken their positions.

Indeed, 4,000 pharmaceutical companies is indeed too many.

China's economic policy has always tended to be big and comprehensive, because under the system of a planned economy, small but beautiful companies are almost non-existent, and they mean that management costs are too high to achieve.

China's railway industry, heavy machinery manufacturing, petroleum industry, finance, communications, aerospace and other fields, are a monopoly or several monopoly model, at present, are still relatively good operating industries, especially compared with coal mines, textiles and other industries, management efficiency and profit margins are not half a star.

To develop the pharmaceutical industry, 4,000 pharmaceutical companies must not work, and it can even be said that the existence of 4,000 pharmaceutical companies has challenged the survival of the entire pharmaceutical industry.

Therefore, it is almost necessary to reduce the size of pharmaceutical companies.

Tang Gong and Li Lao asked several questions in a row, and after Yang Rui answered, they gradually fell into deep thought.

Qiao Gong said with a hot iron: "Yang Rui, shutting down and turning around is a big proposition, you can also talk about it." ”

Yang Rui hesitated for a moment and said, "This is the content of management. ”

"You just talk about pharmaceutical companies, the pharmaceutical industry is your business, besides, didn't you have suggestions in this regard before?" Qiao Gong sold Yang Rui to the stage without hesitation.

Yang Rui couldn't shirk it, hesitated, and said: "In my opinion, what pharmaceutical companies need most is capital, followed by technology and equipment, and the demand for manpower is the lowest." Compared with the machinery manufacturing industry, the degree of automation of pharmaceutical companies can be very high, so although skilled workers are needed, the number of requirements is actually reduced. In other words, the most important financial integration of mergers and acquisitions of pharmaceutical companies is the improvement and complementarity of technology, then the purchase and complementarity of equipment, and finally, the diversion of a large number of workers. ”

Yang Rui did not use the words "elimination or layoff", because before the concept of "laid-off" was proposed, workers were lifelong occupations, and occasionally state-owned enterprises that were closed down and transferred also had to redistribute workers' jobs.

Still, diversion is a brutal and unavoidable topic.

Qiao Gong had already conceived, looked at Tang Li and the others, and said: "I think, what Yang Rui said is very reasonable, if we don't do a pilot, we will use the Jingxi Pharmaceutical General Factory, which has violated the production law rules, as a pilot, how about it?"

"The scale of the BWI Pharmaceutical Factory is huge. Tang Gong looked up.

Qiao Gong just wanted a big one, and immediately said: "There are great benefits, and you can fully find the problem." In addition, the Ministry of Health reported that the handling opinion was to shut down and transfer, which is a ready-made test material. ”

Tang Gong didn't speak, but Li Lao said: "I agree, but you can't simply shut down the matter, it is to deal with it, and it is meaningful to deal with it." ”

"I'm in favor of it, we can analyze it now. Qiao Gong came to his senses, and both eyes were shining.

……

It is hereby explained that the Weibo deity of the bird dolphin is: the diligent Zhiniao Village

People are as their name suggests, don't be confused.