Van Lunding was very silent in the Huarui laboratory, except for talking about some things in the development of new drugs, he rarely chatted or even spoke, and sometimes, he would even watch Yang Rui make one derivitone derivative after another with resentful eyes. Pen Fun Pavilion wWw. ｂiquge。 ｉｎfo

Yes, deferiprone derivatives after ones.

Yang Rui completely listened to Fan Lunding's opinion and decided to make more derivatives of deferiprone for backup.

The development of new drugs is a very moral test, because the public's unusually high requirements for pharmaceutical companies make the risk of clinical trials infinitely increased, and drugs with the same chemical structure can be passed in Europe, not necessarily in the United States, this year, and next year.

Even a company like Pfizer can't guarantee that a drug with a certain chemical structure will definitely pass the FDA review, different chemical structures will have different side effects, and everyone will react differently to the drug, and no one can guess whether your next clinical trial will encounter a certain patient to have a stress response.

Modern clinical trials do not cover the entire population, let alone the screening of clinical trials through genes, so unless it is an important drug that is highly anticipated by the company, a clinical accident is enough to ruin the future of a good drug.

And the solution can only be like buying a lottery ticket, try to buy as many as possible, and try to cover as much as possible.

Of course, under such policy restrictions, the public is not necessarily the drug with the least side effects and the most effective effect, but the most fortunate drug.

In other words, Yang Rui is not convinced that the chemical structure of deferiprone used by the former Indian company must be the one with the best efficacy and the least side effects.

Similarly, Yang Rui is not sure that the chemical structure, which was once the luckiest in another clinical trial, will still stand out.

Therefore, after getting Fan Lunding's reminder, Yang Rui could only make as many active substances as possible.

And his method of making new active substances is also very simple, just copy the generic drugs of the past.

Different generic drugs have different chemical structures, as generic drug companies, if they want to imitate a certain original drug, they often prepare three or four or even six or seven years in advance, with such a long time, weak generic drug companies can always imitate several similar chemical structures, and then enter the clinical trial stage - the review system for generic drugs is much more relaxed than that of original drugs, but despite this, there are not too many generic drugs that can pass the supervision.

But for Yang Rui, who has swept books such as pharmacopoeia, there are one or two generic drugs in a country, and there are too many generic drugs in the world, especially the drugs around the nineties, the structural patents of generic drugs have become invalid, and the generic drugs of various generic drugs are emerging one after another, some of which are quite creative.

Yang Rui didn't have to think too much about it at all, just follow the established steps and make various drugs with different chemical structures in order.

This feeling is actually a bit like the work of graduate school, which is nothing more than achieving the set goals.

Although it's boring, it's actually a little bit of accomplishment.

After all, it's easy to make a brand new compound a day on average.

Think of an ordinary person using a tin hoop and a trash can as if they were doing something big, synthesizing a new compound - well, ordinary people don't care about that.

Even Wei Zhenxue turned a blind eye to Yang Rui's opening behavior.

Although he graduated from chemistry and has worked in the Coal Science Institute for many years, China's chemical engineering major has always been responsible for absorbing the nutrients of Western countries.

However, Van Lunding has not worked at the Institute for many years.

He had studied and worked in Cambridge for many years, and he had never seen a brand new compound done so quickly.

Van Lunding couldn't help but call his former mentor, and at the end of the call, the two sides listened to each other's breathing for a minute, even if the conversation ended.

Since that day, Van Lunding has been even more silent.

Wei Zhenxue asked Fan Lunding a lot of questions because of the reason for Yang Rui's help, but he didn't get a warm and detailed explanation, he was very unhappy, and when he did the experiment, he said to Yang Rui: "This foreigner, his personality is too dark, you see him lowering his head all day, as if others owe him hundreds of thousands, too guilty." ”

"People don't like to talk. Next to him is Wang Wanglei, a scientific researcher with a tiger head and a tiger brain, who is currently a professional scientific research Wang and has been following Yang Rui for a long time.

Wei Zhenxue shook his head: "Didn't you see how much he talked when he first arrived in the laboratory, I think, he saw that we made results, and he was unwilling, or simply jealous, so he didn't speak." ”

"Where will it be, people who graduated from Cambridge are jealous of us. Wang Lei pursed his lips and said, "I heard that foreigners have a salary of tens of thousands of yuan a month, and those who graduated from Cambridge are not even more?"

"Cambridge graduates, and it's not Cambridge that belongs to their family, as far as we do to remove ferrite, they don't have it. Wei Zhenxue also shook his head, and said: "Tens of thousands of yuan a month is also nonsense, we haven't seen foreigners, there are thousands of yuan a month are not young and old, if you want to fall to me, I will save money, spend 50 a month, save money, save enough 200,000, I will resign and go home, eat bank interest every day, and no longer need to nest in the laboratory every day?"

Huang Mao, who was doing polymerase experiments next to him, heard it and couldn't help but say: "Old Wei, we work in the laboratory, not for money, but for common ideals and pursuits. ”

"And then?"

"So, you are not nesting in the laboratory because you don't have 200,000, you are nesting in the laboratory for our ideals and pursuits. ”

Wei Zhenxue stared at Huang Mao for a long time, sighed, and said, "You are wrong, you are nested in the laboratory every day, so there are no hundreds of thousands." ”

Huang Mao was dumbfounded.

Wang Lei laughed, quickly covered his mouth, and said, "I mean, Researcher Wei actually likes to nest in the laboratory, otherwise, why would he be reluctant to go back after work." ”

Wei Zhenxue snorted, turned his head to look around, and said, "What am I going to do when I go home?" There is Wang Xiaoyun in the laboratory, and I only have a yellow-faced woman when I go home. ”

Wang Xiaoyun, who was called by her name, looked up in surprise, and not far from her, Comrade Wang Xiaoyun's husband, Comrade Tu Xian, gently sniffed a jar of liquid to his hand.

Wei Zhenxue saw it, laughed, and hurriedly said: "Lao Tu, you have no sense of humor." ”

Huang Mao laughed out loud and said, "I think it's quite humorous." ”

Yang Rui and the others also laughed. Liquid smell is a very terrible poison, its wound is yellow, it does not scar and does not suppurate, it is so rotten, it is more ruthless than sulfuric acid on the face, and it is somewhat in line with the definition of yellow face...... This is the reason for the laughter of several people, a joke that belongs only to the laboratory.

Listening to their laughter, Fan Lunding felt awkward in his heart, and when he went back in the evening, he couldn't help but call his mentor.

"How many actives do they make now?" the mentor asked Van Lunding.

"21 kinds. Van Lundin's bitterness could be heard through the transatlantic phone.

"Two weeks, from 12 to 21?"

Van Lunding said: "Specifically, it is 11 days, and there are 9 more types. ”

"Unlikely ......"

"That's what I'm trying to say...... Is there such a possibility, he did theoretical research in advance, a lot of theoretical research...... Then, now verify it experimentally. ”

"That's too fast. But ......"

"But what?"

The tutor on the other end of the phone took a breath and said, "It's just Yang Rui's words, it's not completely impossible." ”

"Huh?" Van Lunding was surprised, he never thought that his always proud mentor would say this.

"You probably haven't known about academia for a long time, do you know what everyone thinks of Yang Rui now?"

"I know that several of his recent studies are well-known, and his articles have been published in Cell and Nature, but I don't know what the academic community is saying. "How could Van Lunding know about the academic evaluation of a scholar who has been away from academic circles for too long.

The tutor in Cambridge said solemnly: "There are a lot of comments, and some of them say things that I didn't believe before. ”

"Huh? Van Lunding felt like watching a horror movie, and goosebumps stood up all over his body.

His mentor's voice was even more slow and heavy: "Some people say that Yang Rui will win the Nobel Prize sooner or later, and maybe he will win the Nobel Prize very early, so that he will break the record of the Nobel Prize in physiology and medicine, I didn't believe it originally, but now it seems that it is really possible." ”

Van Lunding's body trembled.

The word Nobel Prize, for academics and researchers in industry, is more exciting than a room of gold.

A person with a Nobel Prize may be able to mobilize more resources than someone with a room of gold.

And that sense of honor is even more attached.

"I can help you ask a few people to see if there are any scholars who know about going to ferrite, and you also learn more from Yang Rui, this is a rare opportunity. The mentor paused for a moment and said, "Last month, we started to use the PCR machine in our laboratory, a very simple but very easy to use instrument, a cross-era invention. ”

……