said that Wu Hongbo was moved, and Yang Rui's plan couldn't have gone smoother. Pen % fun % Pavilion www.biquge.info

If you look down at the domestic biological community, the number of people is too large, and the biology teachers in ordinary primary and secondary schools don't know how many people you want, but when you enter the scientific research community, especially when you look up, the number of people at the top of the pyramid is very small.

Wu Hongbo came forward, and with such a wonderful reward as traveling to the United States, Sinovel Labs quickly sent out six invitations.

At the same time, Yang Rui continued to communicate with several pharmaceutical companies and actively communicated with Benjamin Law Firm.

The content of his communication, mainly the PCR lawsuit, inevitably involves the price negotiation of deferipenone.

Benjamin is a named partner at a well-known law firm in a lawsuit against Sinovel against DuPont, not just for $2,000 an hour in legal fees, but also for more business.

High-value contracts such as milestone VAM agreements have always been a favorite thing for lawyers.

Milestone contracts are extremely complex, coupled with the existence of VAM agreements, and if you don't pay attention to it, you will be cheated. Pharmaceutical companies, like financial companies, are inherently evil and can never be trusted, and lawyers are naturally indispensable.

Within a few days, almost all pharmaceutical companies accepted the model of the milestone VAM agreement, and then began lengthy detailed discussions, and some companies had to consider whether to set up a joint venture subsidiary to undertake the work, as Yang Rui requested.

In fact, the cost of developing new drugs is too high, and some medium-sized pharmaceutical companies can hardly afford it independently.

The average development cost of Phase 1 clinical trials is $1 million, and milestones range from $1 to $55 million, which means that pharmaceutical companies may have to prepare more than $56 million of budgets for this — and while they can't give as much as Yang Rui wants, they still have to prepare budgets to be eligible to compete.

The average development cost for Phase 2 clinical trials is $20 million, and milestones require $20 million to $60 million, which means that pharmaceutical companies may have to budget more than $80 million for this.

The average development cost of Phase 3 is $100 million, and the milestone Yang asks for is $30 million to $90 million, which means that pharmaceutical companies may have to prepare $190 million for it.

As a milestone project, the maximum budget for the entire project could reach $330 million, which is not cheap by any means. It is to repay the money at a sky-high price, at most, it will cut one-third of the budget, and the final cost will still be 200 million US dollars.

This is actually the average development cost of a common drug.

Of course, the cost of 200 million US dollars for pharmaceutical companies is a phased expenditure, which also means that Yang Rui's income will also be phased.

The easiest place for him to get money is the milestone of the first phase of the clinical trial, as long as the safety clinical trial passes, he will get as little as $10 million or 20 million, and as much as 40 or 50 million dollars. As long as the contract is signed, the money will almost certainly be available within half a year.

As for the second and third phases of clinical trials, it will take a long time, and if the pharmaceutical company decides to sell ferritone directly after completing the first phase, it may take even longer. And its income is not necessarily more than that of the second phase, in fact, as far as Yang Rui knows, the second phase may get less money than the first phase.

Because from the second phase, a lot of risks and costs are actually concentrated on pharmaceutical companies. The efforts made by Yang Rui at the end of animal experiments are mainly cashed in the first phase of clinical trials.

According to the usual process of pharmaceutical companies, it often takes three or four years to complete the second phase of clinical trials, which is not surprising if it is done slowly, five or six years, and if it is done quickly, it is rarely shortened to less than two years.

Phase III of clinical trials is even more distant. The development cost of $100 million is mainly caused by the size of 20,000 people, and the average cost of $5,000 per person is really not enough. The 20,000 people were not randomly found by running around, but all of them needed to be recognized or even introduced by doctors, and complex contracts were signed before they could be carried out in batches. It's more difficult than marketing a marketed drug, and only the largest marketing pharmaceutical companies can easily do this kind of work, and the smaller pharmaceutical companies have to mobilize all the people to start a new business.

Yang Rui's eyes were mainly focused on the first phase of the clinical trial. All seven compounds in the first phase of clinical trials have passed, and he can get the most part, and if he is lucky, he may have forty or fifty million. As for the second and third phases, he will take two or thirty million dollars at most.

Of course, the eventual listing will also give him a handsome bonus milestone, perhaps talking about the scale of tens of millions of dollars, but it will take longer, maybe not even ten years.

"Time is the least durable commodity. Yang Rui looked at the schedule listed by Benjamin Law Firm, and couldn't help but sigh.

"For you, in the days to come, just wait to count the money. Hey, I knew that doing research was so lucrative, so I wouldn't go to law school. Hong Kong lawyer Yue Ting gradually replaced the small lawyer who had no sense of existence in Sinovel and officially became Sinovel corporate lawyer, so he also knew some of the relationship between Sinovel and Yang Rui.

$600 an hour is expensive, but making $10 million is still out of reach.

Thinking about Yang Rui's easy access to the first $10 million in his life, he was only in his early 20s, and he was still in a closed continent, Yue Ting was also full of emotion.

Yang Rui just smiled and said: "I care more about the money in my hands than counting the money, you have to make a contract with Jielikang as soon as possible, and sell the catalyst of coenzyme Q10 first." ”

"Okay. ”

"Have you booked your ticket to the U.S.?"

"The PCR lawsuit is the first priority, and this must be dealt with. ”

"No problem, Benjamin also attaches great importance to PCR, this lawsuit is well-known in the US judicial and scientific circles, and the business community and Wall Street are also concerned. ”

"Of course they care, small companies against big conglomerates, if I hadn't been well prepared, I wouldn't know how to die. Yang Rui is also paying attention to the lawsuit in the United States at any time, but the more he pays attention, the more frightened he becomes.

The huge DuPont consortium naturally doesn't have nothing to draw it for.

They really have a chance to win, this kind of thing, Yang Rui thinks it is incredible, PCR is obviously made by me, it is possible for DuPont to win.

However, this is the law in the United States.

DuPont used two Nobel laureates and a large amount of scientific research evidence to prove that it has had relevant research since the 70s.

Not to mention, they really do.

It was also Yang Rui's previous publication of articles, pre-research on heat-resistant polymerase, a large number of videotapes, and the invitation of Nobel laureates, coupled with the joining of a large patent law firm, that allowed Yang Rui to stabilize the situation.

Despite this, the debate between the two sides and several court sessions also lasted for more than half a year, which actually aroused a lot of discussion in the industry.

As a result, Yang Rui had to add money to Benjamin Law Firm, and the budget for the lawsuit slowly grew to nearly $4 million.

For Chinese, this is indeed an astronomical amount, Yang Rui has privately thought more than once that if he did not predict the future of PCR, and accumulated enough funds and made sufficient preparations, this lawsuit really has no need to continue.

$4 million is not the final expense, and victory is not a foregone conclusion. Think about how frustrating it would be if you spent more money and ended up losing the lawsuit or settling it.

With so much money, if you bother to convert it into RMB, you can get more than 30 million yuan, which can be used to buy a house in Beijing, buy hundreds of courtyard houses, and easily sell them for tens of billions of yuan after 30 years.

It may not be as valuable as the $3 billion in PCR, but it's much simpler.

After all, to achieve a PCR value of $3 billion, it is still indispensable to pay and operate, and the house is placed there, but it is much simpler.

Why Chinese enterprises are reluctant to go to the United States to fight lawsuits, and why Chinese state-owned enterprises would rather suffer losses than protest lawsuits, can be understood by calculating the economic accounts. If the leader of a pharmaceutical company spends $4 million in a lawsuit and accidentally loses it, it is really a shameless career. Even if you win, you will probably have to stop on the official road.

However, the rights and interests of PCR are wholly owned by Yang Rui, and Yang Rui can only grit his teeth and sign the checkbook and hand it to Yue Ting.

Yue Ting carefully checked the signature and spelling, put it away and said with a smile: "No problem, I will deposit it in the Cayman company." ”

The offshore company in the Cayman Islands is the parent company of Sinovel, and on top of the offshore company in the Cayman Islands, there are multiple levels of offshore companies that work together to help Yang Rui control Sinovel while hiding himself.

"Please. Yang Rui put down his pen and said with a wordless smile: "More than $1 million as a lawyer's fee, I really didn't think about it before." ”

"Benjamin's fees are high, but they are really powerful, and Hong Kong companies generally don't get such barristers when they are litigating in the United States. Yue Ting smiled and said, "In the near future, it's best for us to keep in touch, I will report to you the quotations of various pharmaceutical companies at any time, and you can also make a decision to inform me." ”

"Good. Yang Rui nodded: "I haven't been at Peking University in the past few days, I'm in Sinovel Labs." ”

"The scope of Peking University is also too broad. Preferably in a place with a phone. ”

"The ion channel lab has a phone, but if I go to class or stay in the dorm somewhere, I can't do it. ”

Yue Ting thought about it contemplatively, from his point of view, it was indeed very important to find Yang Rui in time, he could negotiate instead of Yang Rui, but important issues could not be decided for Yang Rui, if it would take a few hours to find someone every time, the progress of the negotiation could be imagined.

In case a guy like Arnold appears again, giving an hour to decide the time or something, Yue Ting doesn't know what kind of loss will be caused.

After thinking about it, Yue Ting slapped his head and said, "Let's get a pager, can we?" The pager is a bit like a telephone, but it can only call people in one direction, you see the number, you know that someone is looking for it, and the machine is not big, it is smaller than a slap......

"BP machine?" Yang Rui was even more surprised than Yue Ting: "It's available now?"

"There's a name for it, you know?" Yue Ting shook his head in an instant, and answered Yang Rui's question directly: "I heard that Shanghai has just set up a public paging network this year, and Beijing is running it, I don't know if it has been done well, but some units have their own paging stations, such as hospitals and customs, I think, can you join the self-organized wireless paging network through people?"

Yang Rui looked at Yue Ting with strange eyes and said, "You know more technology than me." ”

"Wherever I am, I just care more about things that save time. Yue Ting smiled through the crackdown.

Yang Rui complained in his heart: "I mean the technique of pretending to be forced." ”

……