At the end of the meeting, Xu Zhengping figured out Yang Rui's thoughts, and said in amazement: "Let's do ferrite removal, it's really wrong." Pen %Fun %Pavilion www.biquge.info"

There are those who do biology and there are those who make medicines, but this does not mean that any scholar who does biology can do drug research, and it is impossible to make any medicine like any medicine.

Yang Rui's ion channel laboratory, normally speaking, belongs to the foundation of basic biology, and it has been based on the ion channels of cells, which is almost the lowest bioactive substances that humans can currently access.

If in a few years, with the rise of targeted drugs, the biologists in the ion channel laboratory will really have suitable drug research, and it will be no problem to turn to industry to make some money.

But right now, the research in the ion channel laboratory is too far ahead of drug research, and the scholars in the laboratory are probably not willing to put down their bodies to do industrial work. As far as Xu Zhengping himself is concerned, anyway, they all get about the same salary, why don't you stay in the promising laboratory of Peking University, do promising basic research, and brush papers is a very nervous thing, you take a slow step, and the people behind will catch up, and your previous efforts will be in vain, and after two or three years, you will turn around, and you once occupied the leading frontier position, maybe it has become the rear.

Choosing to do scientific research is to choose a lifetime of competition, a little ideal scientific research workers, starting from the third year of high school, is basically the state of the college entrance examination every year, people who can't stick to it are naturally eliminated, anyway, a scientific research leader to the end, only a few top people are needed, and the rest can be filled with scientific research dogs, and if you can't, you can match a few scientific research apes.

Only a guy like Yang Rui has the spare time to think about doing something else.

However, Yang Rui also understood Xu Zhengping's thoughts, and only said: "Let's go to the doctor who spoke before first to see what the specific situation is." ”

He thought to himself, if the ion channel laboratory can't make drugs, then Sinovel Laboratories will do it.

Although it is not a money-making project, in the end, it should still be able to make money, after all, Yang Rui does not have to worry about the most time-consuming research and development process, nor does he have to worry about not being able to achieve results, and these parts are the most risky. As for clinical trials or something, it is true that it takes energy and time, but the main thing is trouble, the level of drugs is acceptable, clinical trials can always be passable, and so many countries in the world do not necessarily have to sell them globally.

Actually, even if it doesn't make money, Yang Rui doesn't care.

His ultimate goal in establishing Sinovel Lab is to be free, not just for personal pleasure, but also for the financial freedom of pursuing ideals.

You can do whatever you want to do experiments, and you can do what you want to do research, this is Yang Rui's ideal - silver chloride, platinum rods, throwing a piece of pure sodium to see an explosion, and making tea with 4 nines......

Hastily pulling Huarui Labs to make a drug that doesn't make much money doesn't need any explanation, it's just that it's just rich and capricious.

"I want to see how the patient is doing. Yang Rui looked around and said, "I happen to be in the hospital, ask if you can take a look at it on the spot." ”

"Okay. Xu Zhengping had no position of opposition, as the deputy director of the ion channel laboratory, he wanted to support the director Yang Rui, and turned his head to ask Wang Sisheng: "Xiao Wang, do you know the doctor who spoke just now?"

Wang Sisheng said in his heart, "How can I know", turned his head and smiled: "I'll ask." ”

After a while, Wang Sisheng asked someone and said, "It happens to be a doctor from Union Hospital, named Yong Xiaodong." I reported Director Yang's name, and they immediately agreed, and now we are in the inpatient department, and someone will be sent to pick us up later. ”

After a total delay of less than half an hour, Yang Rui was on the first floor of a building in the inpatient department and saw Yong Xiaodong waiting there.

"Director Yang, Director Xu, Comrade Wang......" Yong Xiaodong warmly shook hands with the three of them, and greeted the three scientific research Wang who followed behind, and introduced as he walked: "My current work is focused on thalassemia, you are interested in learning about it, I am very happy, this disease, there are too few people willing to know." ”

Soon, Yang Rui knew the reason why people didn't want to understand.

It's miserable.

If the loss of hair in cancer patients undergoing chemotherapy is a change in appearance, then thalassemia major can be said to be a change in appearance.

The deformed bones due to compensatory hyperplasia have been transformed beyond recognition, and most patients with severe disease are children......

Looking at the deformed face, abdomen, legs, and arms of a child who is the oldest in elementary school, even the eldest Xu Zhengping couldn't stand it anymore, and couldn't help asking: "Why are they all so small?"

"Thalassemia major is a disease of early death. Yong Xiaodong whispered.

The implication is that the older ones are dead.

Xu Zhengping shook his head and said: "I remember that you said in your report today that the average age is between 15 and 20 years old, and all primary school students here are ......."

In fact, most of the children are only in the third grade of elementary school, and many are kindergarten children who don't even understand what is going on......

"Usually those who are sent to our hospital are those whose parents still have a glimmer of hope, and those who cannot be cured by the age of nine or ten usually go home. Yong Xiaodong said in a low voice: "There are not many people with thalassemia in the north, mainly in the south, especially in the Liangguang-Yunnan-Guizhou region, there are more gene carriers of thalassemia and many patients. When they come to the capital, the cost is also large, and if there is no obvious improvement, most of them will choose to go to the hospital at home, or some will not be treated. ”

"Didn't you stick to the treatment?"

Yong Xiaodong smiled bitterly: "We can't talk about treatment at all now, except for blood transfusion and ferramine transfusion, there is no other treatment plan." Moreover, the cost is also significant. ”

Not only is it very expensive, thalassemia major requires long-term blood transfusion and infusion, and when you are a little older, your hemoglobin has dropped, so you must have regular blood transfusions, which is long and dosage, plus the treatment of complications, it can be described as a daily expense.

Yang Rui casually turned his head to take a look, and he could see the decadent father, the sad mother and the painful parents, as well as the numb child.

In less than half a month, the disease that requires blood transfusions once a month at most, as well as the same frequency of iron-removing injections, and the drastic changes in appearance, are not enough for children to feel the beauty of life.

Even if iron is developed, I am afraid that it will not be able to talk about a good life.

However, the pressure will be much less.

Yang Rui thought about it and asked, "If we develop an oral iron removal agent, will it help?"

Yong Xiaodong's eyes lit up and asked, "Is there a pharmaceutical factory that has produced oral iron remover?"

"Not yet, I'd like to find out first. ”

"If there is an oral iron remover, it will definitely help, at least for these families to last a few more years. Yong Xiaodong couldn't bear to say: "Although in the end, it is still the same result, but it should still be different." ”

If you have been a doctor for a long time, you usually don't get too emotional, but in the face of a group, your feelings will also be enriched.

Yang Rui looked at his expression and couldn't help but comfort: "Although the final result is the same, it is also important that the process is different. We are not God, and we can't change the world, but I think there is still a big difference between a child who dies at the age of fifteen or sixteen and becomes critically ill at the age of thirty. ”

"And then there are thalassemia intermediates, and they can make a lot more difference. ”

Yang Rui nodded, and introduced the hydroxypyridone compounds studied by HIDER, and said: "I don't know much about deferiprone either, but as far as I know, the structure of deferiprone is electrically neutral, and it has a certain lipophilicity, and the molecular weight is also small, which means ......"

"It can be absorbed in the gastrointestinal tract!" Yong Xiaodong reacted immediately.

Yang Rui bowed: "And it can penetrate the tissue cell membrane, I don't know how it will behave in the cell, but from a better direction, it should be able to chelate the iron atoms in the cell." ”

Normal infants and young children should pay attention to iron supplementation when eating milk powder, but for children with thalassemia, every little iron loss means that they can prolong their life for a period of time and improve their quality of life.

Yong Xiaodong took two steps excitedly, but after a while, he stopped again, and said with annoyance: "It's a pity that there is no pharmaceutical factory to produce the oral iron-removing agent you said, even if the basic conditions are there, foreign pharmaceutical companies are still unwilling to develop it." ”

The reason why we only talk about foreign pharmaceutical companies is because Chinese pharmaceutical companies simply do not have the ability to create original drugs.

The world's pharmaceutical companies are divided into two categories, one is the original drug company, including the well-known Johnson & Johnson, Pfizer, Bayer, or Jielizeneca and so on.

In addition to original drug companies, there are also professional generic drug companies.

A generic drug company is a company that produces generic drugs after the original drug company's drug patent expires. For example, Viagra is Pfizer, but when Viagra's patent expires, Jinge can be sold, and it is not necessarily cheap, but it saves the unpredictable drug development process, and the arduous clinical trial is equivalent to reducing the cost of hundreds of millions of dollars and saving the average fifteen years of research and development time.

In Europe and the United States, the number of generic drug companies is dozens of times that of original drug companies, and the scale and strength of many companies should not be underestimated.

Some generic drug companies are also very large, such as Israel's Diwa Pharmaceutical, Germany's Sandoz, and the United States' Mylan, all of which are large pharmaceutical companies with annual sales of billions or even tens of billions.

In China, original drug companies basically do not exist, that is, the scale of generic drug companies is very small. In addition to some commonly used popular products, drugs produced abroad in the 60s are not in time to be imitated in China.

In this case, it is naturally very unreliable to count on domestic pharmaceutical companies.

Yang Rui patted Yong Xiaodong and said, "I'll think of a way." ”

"Can you think of a way?" Yong Xiaodong obviously looked disbelieving.

Wang Sisheng couldn't help but say: "Our Director Yang has a good relationship with Jielikang in the UK. ”

Yong Xiaodong's lips moved, but he still couldn't help but say: "It's useless, the British can't have thalassemia." ”

"Not on the British, we on ourselves. Yang Rui looked solemnly at the hospital bed next to him, the child on the bed was lying pitifully on the infusion, I don't know if he was asleep or awake, his chest and legs were skinny, his stomach was high and bulging, his mother sitting on the side lowered her head, and when the doctor came, he just looked up and lowered it heavily.

Xu Zhengping glanced at Yang Rui's gaze, gasped, and hurriedly said, "Director Yang, this matter has to be considered in the long run." ”

"I know. ”

"Director Yang, Yang Rui, making medicine is a research in biochemistry, let's start from scratch, how can we be in time!"

"Of course, we have to do it as soon as possible. Yang Rui retracted his gaze and sighed in his heart, but he secretly made up his mind to make his own original pharmaceutical company.

Even if you don't make money, even if you lose money, you should start this pharmaceutical company first.

No scientific research product is ever produced without input.

The biological and pharmaceutical industries are typical of them.

China needs to have its own original drug company.

If it is industrial and agricultural products, whether you have your own factory or not, in fact, it doesn't matter, the international division of labor and cooperation, you produce precision machine tools, I produce refrigerators, I need your precision machine tools, and you can't do without refrigerators.

Even agricultural products, in fact, there is nothing remarkable, the US government will not deliberately make the Chinese hungry, and there is no need for that, it is nothing more than a little more expensive and a little worse quality.

But medicine is really different.

As Yong Xiaodong said, the British are not allowed to have thalassemia, therefore, it is difficult for British pharmaceutical companies to have the impulse to make thalassemia drugs, the reason why it is difficult is that India is the traditional market of the United Kingdom, and the South Asian region where India is located is the severe area of thalassemia, so in the end, there are Indian companies that insist on making deferiprone out.

Germany, France, Italy, Spain, or Norway and Denmark, which are also in Europe, don't even need to add adjectives like "difficult", it is completely impossible for them to make thalassemia drugs, because there are no thalassemia patients in their country, instead of spending more than ten years studying the drug, and risking the risk of being unfamiliar with life to go abroad to do clinical trials, it is better to choose a common disease in their own country to overcome.

In the final analysis, the genetic diseases that are common to the Chinese people need to be overcome by the pharmaceutical companies in the country.

This will also be the cold reality that all countries and nations will face in the post-genetic era.

If you don't invest in scientific research, you don't want to have a reference for copycats.

If the country is unwilling to invest, people from other countries may sympathize with donations, but they will never donate to a first-class scientific research team for fifteen years, and the same research funds as the bottomless pit.

……