Arnold finished the phone call and came back excitedly to report the good news, and saw that Yang Rui had already drunk a bunch of beer with a table of representatives of pharmaceutical companies. Pen | fun | pavilion www. ｂｉｑｕｇｅ。 ｉｎｆｏ

Arnold's eyes turned red in an instant, as if a man went out to buy a green onion and came back to find three more used sets in the kitchen, or like a man who rushed out to buy a set and came back to find six more broken bitter gourds in the bedroom.

Arnold's heart is bitter like a broken organic bitter melon - my life, my struggle, my goal, not to do such a thing!

"Arnold is here. Drink together. Yang Rui invited Arnold to the table as if he was fine, and even called him a nickname.

In the eyes of his peers, Arnold sat down at the table with cold eyes and said, "Yang Rui, I thought your promise to give Jielikang the right of first refusal was true. ”

"Of course it's true, before signing a contract with any company, I will tell Jielizena and give you a small time to quote. Yang Rui put down the beer glass and said.

Priority was originally like this, Arnold had nothing to say, and said disappointedly: "I thought you would give us a chance to talk about it first, in private." ”

"If it's emotional, don't want it. Yang Rui knows what Arnold thinks, the cooperative relationship between the two sides has become somewhat inseparable today, if the British intercede, if they use the relationship to speak, Yang Rui is really hard to refuse.

"The conditions of JieliZeneca will definitely satisfy you. Arnold was so eager to do the extra questions, especially if he didn't answer the basic questions very well.

Yang Rui said: "I know that Jielizen will give excellent conditions, which are enough to make up for the efforts of Sinovel Labs, and may be enough to make up for many times the efforts of Sinovel Labs, but I have to be responsible for Sinovel and for researchers including me, and we want the best conditions." ”

Yang Rui looked around and said: "Removing ferrenone is my first achievement in the field of pharmacology, and it is also the first achievement of Huarui Laboratory, I don't know if this is ability or good luck, or just a flash of inspiration, I have to try my best to fight for what I can, this is my duty, right?"

"I admit that what you said is very reasonable, you want to give Sinovel an insurance policy, so that it can continue to operate for many years after that, I can understand, but I want to say that JieliZeneca can be your insurance company, and the good relationship with Jielizena can also ensure the long-term operation of Sinovel Laboratory. Arnold has a lot to say, but he chose it because it was a condition that only Generica could offer.

No matter how huge other companies are, they dare not make such a guarantee without the basis of cooperation with Yang Rui.

Yang Rui picked up the beer glass and took a slight sip, letting the liquor rotate in his mouth, feeling the bitter taste.

"Yang Rui, the resources that Jielikang has are world-class, and what we can provide to you is more likely to be the world's first, and I can guarantee that even if Sinovel Labs does not produce any output in the next seven years, I guarantee that you are Jielizen's partners and enjoy the treatment of first-class laboratories. Once again, Arnold came up with a condition that no other company could offer.

In fact, he still has a lot of conditions to say, such as price, such as licensing, but he doesn't want to get caught in a price war, the relationship between the two sides is Arnold's biggest bargaining chip, and the scale of Jielizen is his biggest reliance.

I have to say that Yang Rui is a little excited.

Seven years of partnership and the treatment of a first-class laboratory are really not to be said, and Yang Rui is confident that Arnold can deliver on his promise.

The development of new drugs, especially original drugs, is extremely difficult and increasingly difficult. In the fifties and sixties, pharmaceutical companies were so keen to develop antibiotics that they almost turned over all the bacteria in the soil, and schools like Harvard launched a campaign to let everyone mail the soil near their homes, at that time, antibiotics appeared at a rate of several per month, and it was not difficult for larger pharmaceutical companies to develop a dozen new drugs a year, but by the seventies, with the development of technology and strict drug supervision, single-digit new drugs had become the norm. As far as Yang Rui knows, after 2010, the time expectation for large pharmaceutical companies to develop new drugs has been extended to 10 years—if a new drug can be developed in ten years, it will be fast.

In this context, the patience of pharmaceutical companies is actually very good, not to mention a young and experienced scholar like Yang Rui, or a professor from a famous university who is a little famous, has just set foot in this field, and the patience of pharmaceutical companies can last for two or three years, or even three or four years.

Seven years is beyond the patience of a normal company, but with Arnold's support and world-class results, Yang Rui is indeed qualified to get such a promise.

However, in his heart, Yang Rui did not want such a promise.

If Yang Rui is an ordinary scholar, he should welcome inseparable relationships, and large multinational pharmaceutical companies are the best partners in the field of biology and medicine, of course, they will still bully others and customers, but that does not mean that small pharmaceutical companies will not do this. The difference is only that the big pharmaceutical companies look better, have more patience, have more funding, and have stronger funding and execution capabilities.

It's a pity that Yang Rui is not an ordinary researcher, there are too many things in his head, more than one Jielikang can't eat it, and none of the partners can eat it.

At the current rate, developing a new original drug in two months may seem coincidental or even fantastical to others, but for Yang Rui, this is indeed a work that can be replicated.

What those generic drug companies do after the information of the original drug is made public, Yang Rui can do it.

The only problem is that the complexity of original drugs is far greater than that of generic drugs.

Jielizena has a market value of nearly 100 billion yuan and annual sales of more than 10 billion, but when it comes to new drugs, it is good to have three kinds of drugs every year, and it may be a new drug composed of different compounds with the same target. Just like Yang Rui's deferiprone left seven active substances in the end, if these seven active substances have passed clinical trials, it is equivalent to having seven new drugs.

This is also the reason why deferiprone is valued by many companies, and the sales of deferiprone itself may not be high, but it has a great chance of passing clinical trials and going to market, which is enough for companies to focus on.

Yang Rui's future work will only attract more and more attention, but the scale of Jielikang cannot be rashly expanded.

In fact, pharmaceutical companies often encounter similar situations, such as a lot of compounds synthesized back then, or a lot of targets found back then, what should I do? It's so easy to do, I'll do it again next year.

From the company's point of view, this behavior is called technical reserve.

When Wall Street valuates pharmaceutical companies, stockpiling drugs is also a very important part. Moreover, not only synthetic compounds can be reserved, but also how many phase III clinical trials, how many phase II clinical trials, and how many drugs that have passed animal experiments can also be used as a reference for reserve and evaluation.

At Yang Rui's speed, he doesn't want his invention to be reserved by the company, even if the research after the reserve is more profitable, Yang Rui is not happy.

He needs a lot of money, but his goal has never been to make money.

Yang Rui is destined to find a partner other than Jielikang.

If Arnold's promise is agreed, or after the ferrite is listed, Jielikang will not easily let Yang Rui out.

At that time, Jielikang will definitely strengthen the relationship with Yang Rui, and may have a lot of short-term benefits, but that is not what Yang Rui wants.

Arnold must not have guessed that it was precisely because of his promise that Yang Rui made up his mind.

"I believe your words, but Sinovel wants to be on its own. Yang Rui clearly rejected Arnold, then opened a bottle of beer, poured a full cup in front of Arnold, touched it lightly with a beer bottle, and said, "Do your duty." ”

"Do your duty. Yang Rui raised his glass to the others again.

"Do your duty!" everyone raised their glasses.

Raymond of Greenstone Point even drank a large glass of beer. These business elites from developed countries do have a sense of pride in "dutifulness", and if they are not dutiful, who would want to sit on the streets of a foreign country, eat the offal of cows, sheep and pigs, and smell the rotten smell of stinky tofu.

"How does it taste?" Yang Rui chewed on the stew, pushed it to the middle of the table, and said, "These two of mine are my favorite Beijing snacks, you're welcome." ”

The elites grabbed a piece of belly and grinded their teeth hard.

After a while, the Japanese took the lead in raising their heads, and said with tears in their eyes: "Very delicious, Chinese food is broad and profound, so delicious." ”

Raymond also cocked his thumb, his eyes flashed with sparkles, and he choked up: "Chinese food, it's amazing." ”

"It's good to like it, it's good to like it. Yang Rui smiled and put down his chopsticks.

The others hurriedly dropped their chopsticks, and the Italian took a deep breath, then pinched his nose suddenly, his eyes wide.

"Stinky tofu doesn't smell good, but it's delicious. Yang Rui explained with a smile, and said: "China, like other countries in the world, has many characteristics of its own, and Chinese also have many habits of their own, but the whole world has similar problems, the biggest trouble, in today's world, I think, probably disease." ”

Yang Rui pointed at himself and the Americans as he spoke, and said with a smile: "The Cold War should no longer be a hot issue." ”

"Maybe Reagan cares, I don't. Raymond said with a smile.

"I don't care, what I care about is whether deferiprone can be successfully marketed and as soon as possible. Seeing that Yang Rui finally got to the point, everyone else straightened their waists.

"Do you want to have a small auction?" asked the Italian.

"No, no, no, what I want now is not competition, but cooperation. Yang Rui shook his head again and again: "That's what I just said, I hope that deferiprone can be successfully listed, and it will be listed as soon as possible, so I ask the company that buys deferiprone to be strong and has a strong ability to market drugs." ”

Representatives of several companies did not look good.

If there is an evaluation standard, a company with new drugs on the market every year is a company with a strong ability to market drugs, just like a film company that produces new movies every year, it can be called a strong film production company.

And there will never be more companies that can do this.

More than half of the companies here are not strong.

"Please be still. Yang Rui's smile was very contagious, he raised his glass again, and said: "I know that different pharmaceutical companies have different business models, for example, some companies are good at drug development......"

He looked at the British and Norwegians.

"There are companies that are good at marketing. Yang Rui looked at the American Raymond.

"There are companies that are good at developing new indications for existing drugs. Yang Rui looked at the Germans and Japanese.

"Some companies are good at ......" Yang Rui looked at the rest of the Italians, who were eager to try, and said, "Good at some other jobs......

"But anyway. Yang Ruimeng clapped his hands and said with a smile: "The listing of new drugs is a big project, I respect your way of doing business, but I will choose the company or combination of companies with the most listing ability." ”

Except for the Italians, who are still confused about what "other" is, other companies have understood.

Raymond asked, "You want you to join forces and buy a patent for deferiprone ?"

"It is your freedom to unite or not to unite. But for companies that are more capable of going public, I am willing to cede some of the benefits. Yang Rui paused for a moment and said, "We can bet." ”

At this moment, representatives of various companies were interested.

The pharmaceutical industry is one of the industries most closely related to finance, and those M&A agreements that can easily cost tens of millions of dollars require the participation of investment banks, those new drug development that can easily cost hundreds of millions or even billions of yuan need the hedging of the insurance industry, and those sales revenue of billions or even tens of billions of dollars require the intervention of commercial banks.

VAM is the most common contract in the development of new drugs.

In the process of developing a new drug with such a low probability, scientists and laboratories are gambling, laboratories are gambling with biotechnology companies, biotechnology companies are gambling with pharmaceutical companies, and pharmaceutical companies can be gambling with Wall Street.

Of course, the reason why everyone likes VAM agreements is often not because of locking in profits, but because more people simply like to gamble, just like many commodity circulation companies silently modify futures hedging transactions into futures hedging and value-added transactions.

For pharmaceutical companies that are in an advantageous position in the VAM agreement, they can choose to sell the higher-risk VAM to Wall Street, and keep the lower-risk and higher-profit VAM to themselves.

Yang Rui's request is tantamount to guaranteeing the profits of pharmaceutical companies.

Everybody likes a profit that doesn't lose money.