Pharmaceutical companies are very capricious in the Jinyuan world, if Yang Rui is a Chinese-American or something, let alone talking about business with Pfizer, he can be recruited by Pfizer and thank the lord Longen.

If you don't get it right, it's just a group of lawyers who pounce on it and make you pay for your doubtful life.

Today, Yang Rui is the head of the ion channel laboratory, the owner of the Huarui laboratory, the first generation of Yang Rui's genetic engineering laboratory, the inventor of PCR, the pioneer of the human gene era, the king of G protein-coupled receptors, the breakthrough of ion channels, the Nobel Prize winner, the real king of genetic engineering, the controller of the cow embryo, the setter of Chinese medical standards, the pioneer of the 863 Project, the rescuer of millions of patients with irregular heartbeats, the male god of Chinese and foreign media, the father of cloned sheep, the terminator of thalassemia, the expander of coenzyme Q10, the lightning rod of the Chinese scientific community, and the supreme monarch of 64 experimental dogs……

As a pure Chinese and Chinese scientist, backed by the big tree of China, he can question life with foreign companies and state-owned enterprises in minutes, or he can formulate policies to make pharmaceutical companies that want to develop in China look up to the stars and lament the injustice of the world.

Being a big boss in China, a country with a closed and huge market economy, has such advantages. Unlike countries such as Japan and South Korea, if you want to implement a drug closure policy, you have to consider the implementation of security regulations.

Needless to say, it is not uncommon to influence the policies of other countries, and in order to unite with insurance companies to make money, they can change the medical insurance policy, leaving people with no place to die.

However, China has never been a country that plays its cards by common sense.

Even without Yang Rui's involvement, Pfizer will encounter many problems in China. For example, the name "Viagra" was preemptively registered by domestic companies, and the result was that there was no result in a lawsuit for several years, and until the end of the patent period, Pfizer could only be named Viagra.

Pfizer's problems don't end there. After the expiration of Viagra's patent, the domestic Jin Ge raised the banner of competition, and in addition to advertising, their most ruthless move was to break Viagra into the prescription drug industry.

For a long time, Chinese who wanted to buy Viagra needed a prescription to buy it, and Chinese who wanted to buy Jingo, went to any small pharmacy, as long as they brought money, they could get what they wanted.

Is this competition legitimate? At least at the policy level, it's the result of competition.

Whether a drug can be marketed, whether it should be included in the prescription drug list, what special requirements there are, whether it can be produced in the country, whether it must be produced in the country, whether it must be produced in the country, and whether to do further testing and clinical trials are ultimately decided by the bigwigs of various committees.

Faced with a market of 1.2 billion people with an average annual growth rate of more than 10%, Pfizer is easily unwilling to offend the bigwigs.

Even, in order to make up for the relationship, Pfizer also paid a China expert to go to China to negotiate with Yang Rui.

"Franky, why did you come on behalf of Pfizer and not do it on Jielikang?" Yang Rui was stunned for a few seconds when he saw Pfizer's representative.

He hadn't seen this big British fat in a while.

Frankie smiled like a cracked doughnut and said, "I opened a special consulting company to provide services to pharmaceutical companies about China, and my income has increased several times. ”

"You're your own boss?" Yang Rui gave a thumbs up to his old acquaintance, Comrade Frankie.

He liked this chubby Englishman, and Frankie was much more sensible and communicative than the arrogant and prejudiced foreigners that are common today.

Frankie can eat this bowl of rice because everyone likes him.

Seeing that Yang Rui agreed with his choice, Frankie was very happy, so he used the Chinese he had just learned, cocked his tongue, and said: "It's all up to the brothers!"

Yang Rui laughed, nodded Franky, and said, "With your efforts to learn Chinese, I want to invite you to dinner." Well, go to my lab. I'll let Old Man Yu take charge. ”

"Chef Yu's craftsmanship is 3 stars. Frankie was hungry as he spoke. He's talking about three Michelin stars, the highest state.

"Yes, you've eaten the food cooked by Chef Yu, that's good, don't introduce it, do you want to order?" Yang Rui took out Chinese-style hospitality. For strange foreigners, he doesn't have such a mood.

"Chef Yu is here to choose. Frankie paused and said, "If you can, stewed lion's head, I want two." ”

"Well, there are two stewed lion heads with a big fist, and the rest are for Chef Yu to choose, there is a ......" Yang Rui looked at Frankie's broader figure and said, "There are seven or eight dishes, it should be about the same, a little bigger." ”

Frankie listened to the translator's whisper and nodded repeatedly: "The big portion, the big portion is good." ”

Neither of them had any intention of talking about business, but Connell, the manager of Pfizer, was extremely happy, thinking that the six-figure expenditure was not in vain.

Chef Yu is older, so he has less time to cook in person, but more time to think, and the taste of the dishes he makes has improved to a higher level.

However, most of the dishes are made by his apprentices.

said that he is an apprentice, and now he is also a chef, and when he is placed outside, he is also a small celebrity in the culinary world, whether it is frying or steaming, he has his own characteristics.

For example, Frankie's favorite stewed lion's head, the traditional method is to use a flat knife to slice the pork ribs into the size of pomegranate seeds, and the optimal ratio is seven fat and three thin, but Chef Yu's second apprentice has already begun to consider health factors.

The lion head he made is not as fat as the master's, and at the same time, the ratio of fat to thin is five to five, and the oil is skimmed with ice water, which not only maintains the tender and Q elastic taste, but also increases the proportion of lean meat, making the stewed lion head healthier and more suitable for people who are not short of meat.

Of course, there is no way to say that you eat too much because it is delicious.

As for whether it is authentic or not, Yang Rui has long been indifferent.

Modern people eat famous dishes and pursue authentic mentality is the most inauthentic. Authenticity can only be said to be in line with the taste of a generation, and if it is not good, it is in line with the taste of a literati. The worst is that it is in line with the preferences of people in a region, and it is still quite far from delicious.

From this point of view, eating authentic food is equivalent to a tourist queue and a photo at the entrance of the scenic spot, which is eaten for the circle of friends.

"Professor Yang, how did you come up with the idea of buying sildenafil? After eating to the point where he couldn't walk, Frankie leaned back in his chair, touched his stomach with his hand, and asked about serious things with a smile.

"I'm bullish on the prospects for nitric oxide drugs. Yang Rui did not hide his approval, took a sip of wine, and spoke slowly.

Sildenafil is an active drug that has been tested for animal safety, and no matter how cheap it is, it costs tens of millions of dollars, and if it is not recognized and optimistic, there is no reason to buy it.

Nitric oxide drugs were also the most popular type of drugs in the past two years. The so-called nitric oxide drugs, the most famous of which is nitroglycerin, which is the Nobel dynamite ingredient, also has a miraculous effect on angina, but for a hundred years, people did not know why.

It wasn't until the end of the 80s, that is, in the past two or three years, that the biological community slowly figured out that it was nitroglycerin and other organic nitrenzymes that could increase the concentration of the second messenger in human tissues, and the way it worked was to metabolize nitric oxide.

This is a new mode of signaling, a deep understanding of the human self.

The term nitric oxide has become so hot that in a few years, it will even win the Nobel Prize.

That's why Pfizer conducted the sildenafil study, and they screened a large number of molecules to finally select this small molecule compound, which was named UK-92,480.

As can be seen from its naming number, it is very troublesome to sieve a molecule out.

Although Yang Rui believes that there must be other molecules that can exert similar or stronger effects, but if he is given tens of millions of dollars, or even hundreds of millions of dollars, he may not be able to screen out.

Pfizer's reluctance to put it on the shelves is also for this reason.

Nitric oxide drugs have just become lively, and now they are sold, and it is really not easy to sift out a usable one that is so safe.

However, China is also a big market that has just become lively, and it is also unwilling for Pfizer to find a big obstacle for itself as soon as it opens.

Frankie took Pfizer's money, so naturally he wanted to help Pfizer speak, he also took a sip of white wine, grinned spicy, and said happily: "Why do you fall in love with Sildenafil, do you have to do it? Doesn't this make Pfizer ask for a sky-high price?"

On the surface, he is helping Yang Rui speak, but in fact, he is also raising the price.

Pfizer was still reluctant to sell, and at this time, Yang Rui was forced to come out to talk, and the first choice was to open a sky-high price.

Yang Rui was not surprised, holding a wine glass, and said: "I chose sildenafil because it is the safest among nitric oxide drugs." Sinovel's first drug, not to mention the efficacy, safety is something that needs to be paid attention to. ”

"Hey, is this the direction of your business?" Frankie was suddenly led crooked by Yang Rui.

Yang Rui nodded and said, "Sort of." Okay, let's talk about Pfizer's offer. ”

"You're in such a hurry, aren't you asking people to pay a high price? Frankie used the same tactics again.

Yang Rui leaned back in the chair, put his hands to the side, with the expression of a big man, and said, "Let's try it." ”

"This ......" Frankie was suddenly shocked by Yang Rui.

His task is very simple, contact Yang Rui, ease relations, and make an offer, if he angers Yang Rui and destroys the Chinese market, Pfizer is unhappy, he will be blind.

"Connell, come on. Frankie quickly found a scapegoat.

Pfizer's manager didn't care, he didn't know Yang Rui in the first place, and he didn't establish any relationship, hesitated for a few seconds, and said: "If you only sell sildenafil in the Chinese market......"

"There is no such thing as selling, what you are holding in your hands now is a compound, and it is not a compliant drug, could it be that I have developed a new drug and only sell it in China? Am I crazy?" Yang Rui immediately interrupted Connell's words.

The development of a new drug will cost hundreds of millions of dollars if it goes well, and there is no reason to sell it in just one place.

If it can cure alien diseases, pharmaceutical companies dare to invest money to restart the Apollo program.

Connell asked for a sky-high price and said with a smile: "You can leave the market outside of China to us......"

"Agency sales is a matter of the future, and now we will talk about the transaction of compounds. "When Yang Rui really wants to sell the blue pills, he still needs a foreign pharmaceutical company to be an agency, but that is a matter of the future, and it is meaningless to talk about these things before seeing the effect.

Connell just said casually, and at this time he couldn't help but look at Frankie, and then said: "We have spent hundreds of millions of dollars to develop sildenafil......

"If you want to entertain me, there is no need. Yang Rui stood up suddenly.

"Professor Yang Rui, how about our cooperation in development? If you are interested in sildenafil, we are willing to use an open program to cooperate with you, and the cooperation program can be very open. Connell desperately hinted.

For Pfizer, the allure of Nobel laureates is also very great.

Especially Yang Rui, he has a precedent for developing new drugs and succeeding, and he is a cutting-edge biologist who has made G protein-coupled receptors, and his qualifications are several planes stronger than the current head of sildenafil, Terlet, it can be said that as long as Yang Rui is willing to cooperate, the terms are not too harsh, and Pfizer is very interested.

Even if he doesn't achieve anything, when the time comes, the new drug sildenafil will be developed by a Nobel Prize winner, and it may be sold for hundreds of millions of dollars more.

That's the biggest reason why Frankie gets paid six figures.

He immediately said, "Professor Yang, this is a rare opportunity, you can put forward any conditions." Sildenafil has just done animal experiments, and it's still far from being launched, so maybe you'll sell it then, so why don't you start working together now?"

The drug of deferiprone is a long-term recovery project, and Yang Rui is too lazy to take the time to do it, so he sold it in a milestone way.

Even if Viagra wants to cooperate, it is after discovering its true efficacy.

"Find someone who can make a decision and ask him to make an offer. Yang Rui was not affected in the slightest by Frankie's words, and said: "I can open a high price, otherwise, I will buy other kinds of nitric oxide compounds, if I develop them first, the value of sildenafil will be greatly reduced." ”

The greatest value of a new drug lies in its new mechanism to treat diseases.

In other words, patients who have not tolerated certain types of drugs in the past may be better suited to taking new drugs. New patients represent higher sales.

Naturally, if a similar drug is marketed first, the drug that comes on the market later will inevitably be affected. In particular, according to the rules of the US FDA, the efficacy of drugs that are marketed later should be compared with those that are marketed first.

If the efficacy of the drug is comparable or inferior, the drug developed after the development cannot even be marketed, and for a company, the blow to the stock price alone is enough to choke.

It was a multi-billion-dollar business decision that Connell couldn't do.

He immediately bowed his head and said, "I'll notify the company headquarters immediately." ”

After speaking, he said casually: "Mr. Yang Rui, I hope that our negotiations will not interfere with Pfizer's business in China......

"Of course it will interfere. Yang Rui is not a little white rabbit, and said calmly: "A company that can't make a correct business judgment can't do business well, you can relay the Pfizer leadership in the same words." ”

"Professor Yang, I would like to toast you. Frankie couldn't be convinced.

The more domineering Yang Rui is, the more he likes it, it is impossible for Pfizer to give up the market of one-sixth of the world's population, and Yang Rui's pass is something they must pass.

Frankie only thinks that his consulting company has a lot to offer.

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