gave Frankie 300 pig brains, and he couldn't have imagined that Yang Rui would run to develop a new drug. Pen "Fun" Pavilion www.biquge.info

If you give Frankie another 600 pig brains, Frankie can't imagine that Yang Rui said that when he developed a new drug, he really made an active substance.

Of course, the active substance can still be regarded as a medicine, the process of new drug development is extremely cumbersome, and the work in the laboratory, if it is distributed by workload, may be less than half of the total work, and the part that Yang Rui is currently doing is far from one-third of the laboratory work.

Still, Frankie hadn't heard anything like that from other companies.

Arnold, who was seduced by him, had also never heard anything like it.

In fact, compared to Frankie's habit of shock, Comrade Arnold faced the shock as an entry-level player, and when he entered the door of the Sinovel laboratory, Arnold couldn't help but whisper to Frankie: "It's only been a few days?"

"Of course not, he was still working on the catalyst for coenzyme Q10 a few days ago, and in the past two months, hasn't he written a book? "Frankie has indeed been paying attention to Yang Rui for a long time, if it weren't for the fact that China does not have a developed media and information industry in Europe and the United States, Frankie would have investigated Yang Rui to the bottom of the day.

Arnold was the person in charge of the catalyst contract with Yang Rui two months ago, and during his stay in the capital, he basically negotiated terms with Japanese and Norwegian companies.

In other words, several multinational companies are dragging it out, they not only want to see the development of the situation, but also want to lower Yang Rui's offer.

After all, no matter how high the profit of the drug is, there is no reason to take 5% of the dry shares to Yang Rui for nothing, and it is a dividend of global sales. Although coenzyme Q10 is far from being a blockbuster-level drug, and even a quasi-blockbuster, it is also a medium-sized variety with annual sales of more than 100 million yuan in a single company.

You can't give Yang Rui $50 million a year. Such an agreement, the British feel pain when they think about it.

Even now, with the sales of coenzyme Q10, 2% of the income dividend is a lot.

In the case of a stable market, Jielikang can usually get more than 30% of the profits, and 2% of the income dividend is equivalent to 0.6% of the dividends, and the current annual sales of coenzyme Q10 of more than 100 million US dollars are equivalent to a stable income of 600,000 US dollars per year, which is also a lot and there is room for growth.

This is also an excellent condition that biologists can get, even if a well-known professor in the United States, if he signs a contract, he can get $600,000 in drought and flood protection, then he will jump happily.

It's a pity that Yang Rui is not satisfied.

Arnold and his foreign colleagues can only be consumed tacitly.

However, this is also a catalyst formula for coenzyme Q10, if it is replaced by a big thing such as interferon, there will definitely be no tacit understanding, and it will have been rushed out of the wild.

In order to obtain a drug, the price that large pharmaceutical companies are willing to pay is unimaginable to ordinary people. For example, in order to obtain Lipitor, Pfizer eventually bought its development company, Warnerlambert, for $82.4 billion, and while the latter's shareholders made more money, Pfizer also received $130 billion in total sales from Lipitor, and its peak annual sales were $13 billion, which is more than the government tax revenue of many countries.

However, the catalyst that can increase the yield of a drug is not an exclusive drug after all.

Arnold also put aside the catalyst for the time being, looked through Yang Rui's experimental records, and asked, "What kind of cooperation do you want?"

"This is the first time we've developed a drug, so we need to collaborate on everything. Yang Rui shrugged his shoulders and said, "It's mainly information, if you want, I can pay a consulting fee." ”

"How much is the consultation fee?"

"$10,000 for reimbursement of airfares and hotels. ”

Arnold smiled dumbly: "$10,000 is not enough for an investigator." ”

"I know. Yang Rui smiled.

Arnold's face changed: "You want Terric Kangbai to work?"

"It's not a bad thing for you to send two people involved to keep track of our progress, right? ”

"That's not possible. Arnold smiled at the corner of his mouth, he wanted to say, you gave the formula of the coenzyme Q10 catalyst to Jielizen, but this time is not suitable to mention this matter, Arnold endured it.

Yang Rui shrugged his shoulders and said: "Then don't cooperate, I invite you to be observers, you can say if you want to say it, even if you don't want to say it, this is your advantage, right." ”

"Don't have to sign a contract?" Arnold's heart moved, and it didn't hurt to understand the situation unilaterally.

Yang Rui shook his head: "At least sign a confidentiality contract." ”

"What else do you observe when you sign a contract?" Observers who can't report ......"

"You just report the results, and you don't need to talk about the process. "Deferiprone that has just reached the synthesis stage, as long as you don't let a specialized pharmacologist look at it and don't take pictures, you can't leak much.

Arnold was indeed very curious because of Yang Rui's relationship, and couldn't help but hesitate.

"Why don't you be an observer for a day and see. Yang Rui then asked the company's lawyer who was waiting in the laboratory to come over and sign the confidentiality agreement for Arnold.

Arnold refused, read the agreement carefully, and signed his name.

"Old Wei, show it to the British gentlemen. Yang Rui gave the two of them white coats, led them into the laboratory, and introduced ferrite ketoxone.

It is impossible for Yang Rui to offer a normal price to Jielikang, because he can't afford to make a price. The medical industry is an industry with a sound industrial chain to the point of perversion, and every job has a price, and it is ridiculously expensive.

For example, the most annoying clinical trial, many people think that clinical trials are drug research conducted by pharmaceutical companies in conjunction with hospitals or independently, but in fact, there have been clinical trial companies in Europe and the United States for a long time, and they specialize in providing clinical trial services for various pharmaceutical companies, with annual sales of more than 1 billion.

As for professional consulting firms, they are usually foolish, but the fees are even more ridiculously expensive, and the million-dollar price is just the beginning.

At present, pharmaceutical companies often spend tens of millions or even hundreds of millions of dollars for preclinical research, half of which is used outside the laboratory, and Yang Rui cannot afford this money.

His income mainly comes from Jielizene's dividends, and his expenses are mainly used for lawyers' fees, the former can be slightly more than the latter, enough for Yang Rui to carry out some experiments that are difficult to carry out in China, such as the synthesis of deferiprone , but after the synthesis, the degree of spending on any part is not something that Yang Rui can afford, let alone the ability to outsource, or outsource to Jielizen.

In fact, many domestic laboratories in later generations did outsourcing work from abroad, such as animal experiments, such as the determination of active ingredients, etc., which were complicated and quite profitable, but in essence, it was similar to Foxconn's form, which was the profit extracted by reducing costs, and the cost of being reduced was usually a scientific research king, or a tutor's student, or a small master or doctor who had just graduated.

In the long industrial chain of pharmaceuticals, the higher the upper echelons, the higher the capital required, the greater the risk taken, and the more profit obtained.

Domestic companies and laboratories are weak and do not outsource, nor can they make original drugs.

Even the research and development of original drugs in the 80s is not something that Chinese laboratories can undertake.

In this regard, Yang Rui is looking to Jielikang.

It's not a comfortable thing to ask for someone, but your skills are not as good as others, and you have to bow your head when it's time to bow your head.

Making medicine is not making art, and those who do art can advocate strong orders, pretend to be wronged, be indignant, be angry, and take it for granted and disdain.

But if you don't bow your head if you don't have the same skills as others, you are wasting your time and energy, your own accumulation and the trust of the people around you.

This time, energy, accumulation and trust is often measured in ten years.

Wasting ten years of the essence of one or even several researchers, just in order not to bow down once, the only people who can do such things are bureaucratic artists and brutes.

Yang Rui is not one of them.

As a novice in the pharmaceutical field, Yang Rui has little experience, unlike writing papers or monographs, Yang Rui's contact with pharmaceutical factories is limited to the laboratory and production part.

How to develop a drug is basically out of his educational direction.

In 84 years of China, no one understands this.

Domestic pharmaceutical companies may know how to pass the domestic drug review, but to pass the review of the drug regulatory agencies of the United States, the United Kingdom, and France, which are major drug consuming countries, Yang Rui must find Jielizen's help.

This is not only for the safety of the drug itself, but also for the purpose of deferiprone to achieve inexpensive thalassemia control.

The synthesis of an active substance of deferiprone is only the first step of the long march, and next, Yang Rui has to synthesize more active substances of deferiprone to find the most appropriate deferiprone molecule, the same core molecule with different side chains, the obtained may be completely different medicinal properties, and more toxic.

And the cost of doing the rest can be millions, tens of millions, or even billions of dollars.

Regardless of whether Yang Rui can afford such an expense, he has no reason to bear it.

The responsibility of pharmaceutical companies is to manufacture drugs, not charity, let alone charity, and deferiprone must be able to obtain sales that exceed the cost in order to continue R&D and production lines, and to continue to develop Huarui.

And to do this, there must be patients abroad to share the cost.

"Lao Huang, you follow Arnold and Mr. French and show him our results. Old Wei, let's continue. Yang Rui rubbed his hands and said directly in English: "The fifth synthesis experiment of ferrione begins." ”

……