Grace's appearance caused ripples in the Sinovel laboratory. Pen ~ fun ~ pavilion www.biquge.info

There are many foreigners in Yanjing City, and there are many people who pursue fashion, but it is not easy to see a woman like Grace, who has a beautiful figure and unique fashion taste.

At first glance, this looks like the outfit of a female soldier on the battlefield, which is a little rough, but if you look closely, the large embroidery on the back of the jacket and the spliced leather on the legs are extremely different.

Wei Zhenxue commented on the red-haired and blue-eyed girl through the window without hesitation: "When I was in the village, when I saw four colors at one time, I ran into a leopard. ”

"You grew up in the compound, when did you live in the village. Huang Mao knew Wei Zhen well, and he pierced him in one sentence.

Wei Zhenxue coughed and said, "My grandmother's family lives in the village. ”

"Your grandmother is from the Coal Authority. Huang Mao sighed, very worried about Wei Zhenxue's nonsense skills.

Wei Zhenxue coughed vigorously again and said, "What's wrong with the Coal Management Bureau, the Coal Management Bureau doesn't have a hometown." ”

"It's okay to have a hometown, but your hometown is Da*Tong, is there a leopard in Datong?"

Wei Zhenxue's coughing lungs were about to come out, and he said: "It's purely against me, right, why can't we have a leopard in our big ......* Tong?

Thinking about it, he felt that it didn't match his previous words, Wei Zhenxue coughed again, and continued: "The leopard from our big * same zoo ran out, and ran to our village for me to see, okay!"

"Lines are ......"

"What's the problem?"

"Just one. ”

"You say. Wei Zhenxue was furious.

Huang Mao took two steps back and said, "There are only three colors of leopards." ”

"What?"

"Yellow, black and white, haven't you been to the zoo to see it?" Huang Mao said with a smile.

Wei Zhenxue coughed vigorously, coughed vigorously: "I was in my grandmother's hometown, and I saw a leopard running out of the zoo, it was definitely four colors, maybe it was glued with soot, yes, it must be soot." ”

"The soot is black...... Li Wenqiang asked in a low voice.

Wei Zhenxue couldn't wait to cough his lungs out.

In the courtyard, Grace listened to the deafening coughing sound in the room and asked with some concern, "Does anyone of you have the flu?" or is it a very serious pneumonia. ”

"No, they're playing games. Duan Bo, who went out to do research work, lied with a clear conscience.

"Learn the sound of pneumonia?" Grace said imaginatively, "is it a new project in your lab?"

"Of course not, they're just playing. Let's go to the lab here......" Duan Bo was a little embarrassed and the two people led into the laboratory, and then introduced the recent work.

With her hands in her trouser pockets, Grace walked around the main laboratory in a handsome manner, and asked, "Who is Yang Rui? I heard that he is the main researcher of deferione, right?"

"Yes, Yang Rui's words, I haven't come today. Duan Bo looked at his watch and said, "He only came over at noon in the last few days, do you want to wait any longer?"

"Of course, I'm here to see him. Grace said and found a place to sit down, and said, "You go and get busy, I'll wait for Yang Rui to come and see him myself." By the way, what does he look like?"

"What does it look like...... Duan Bo recalled the description suitable for Yang Rui, and replied in written language: "It looks good, it is very dignified." ”

The translator twitched and gave Grace a good translation.

Grace didn't understand, "What's that?"

"I'll know when I see you. Duan Bo replied.

Two hours later, Yang Rui appeared, and Grace recognized it at a glance.

"I didn't expect that there are such men in China. Grace tilted her head and watched Yang Rui walk over step by step with appreciative eyes.

At this time, it was Huang Mao who was in charge of accompanying him, and he said with a strange expression: "There are all kinds of wonders in the world, hundreds of millions of people in China, and there are all kinds of men. ”

Grace shook her head and said, "Impossible. ”

Huang Mao was surprised: "Why?"

"I know all the scholars above the level of biology, and there is no such goods as Yang Rui. Grace used the adjective she had just been translated.

Duan Bo, who was introverted, was speechless for an instant.

Grace stared at Yang Rui for a while before asking, "It took you three weeks to make 19 derivatives of deferiprone deferrione?"

Yang Rui was also a little stunned by Grace's appearance, looked between her blue eyes and the high bridge of her nose, and said, "You are the expert that Van Lunding said?"

"Yes, this is Professor Grace Bryan from our Cambridge. Van Lunding suddenly sensed a deep sense of crisis, and he stood directly between Yang Rui and Grace, and said, "We can save a little time for greetings to learn about the work of Huarui Lab on ferriketone." ”

"I guess you mean my job. Yang Rui did not hesitate to take credit for himself, and he was telling the truth, in the process of developing deferiprone deferrione, except for the help of a few experimental dogs, all the work was done by him.

Van Lunding laughed twice: "Okay, your job ......"

"Can I see the log of your experiments, unless it's too confidential. ”

"It's really confidential, you can see what we've sifted out. Yang Rui knew that there would be people who wanted to know about his work, especially the observation of professionals, and his experimental records were complete and worthy of inspection, but as a drug that had not yet been interviewed, he had no reason to disclose all the information to the other party.

"The filtered part is fine. Grace got the bound document and flipped through it quickly.

Synthesizing a compound is extremely difficult, but the molecular formula and synthesis process are simple.

"I want to ask a question. Grace put the document aside and said, "Why did you choose to do ferriprone chelates?

"Maybe, but I think it's more realistic to go to ferrite. Yang Rui shrugged and replied.

Grace held her chin with her hand, posed, and thought for a moment: "If it were me, in order to make a product as soon as possible, I would choose LCL670, its two phenolic hydroxyl groups and the 4 N positions on the triazole ring constitute 3 chelation sites, in terms of the affinity of iron ions, it is about the same as deferiprone phase, but its lipophilicity is stronger, ensuring the ability to enter the cell after oral absorption, no matter how you think about it, it is more realistic than deferiprone . ”

Her string of words instantly made the research atmosphere in the laboratory thicken, and several people looked at Yang Rui, wanting to hear how he answered.

Yang Rui just stretched out his hands and said: "How the lipophilicity of LCL670 behaves in the human body, I'm afraid we will not know until clinical trials are done, and before that, LCL670 is more difficult to synthesize, isn't it?"

Grace smiled, looked at Yang Rui with a focused gaze, and said, "You can synthesize 19 ferriprone compounds in 3 weeks, isn't it easy to synthesize LCL670?"

Yang Rui was stunned, this sentence really hit his weakness.

Synthesize 19 kinds of deferiprone compounds in 3 weeks, even if others say that Yang Rui does it fast, Yang Rui doesn't care, anyway, I do it fast because I'm amazing, and you do it slowly because you're stupid, such a subtext doesn't need to be said at all.

But Grace's question is acute, since Yang Rui is so good at synthesis, why doesn't he synthesize compounds that are more difficult but seem to be more effective?

Moreover, Grace's vision is still very good, and LCL670 will also pass the review of the Food and Drug Administration in future generations and become a potent drug with the trade name deferasirox, which is stronger than deferiprone in terms of overall safety and efficacy.

In this regard, Yang Rui is difficult to explain, he can't say that he is very worried about the risk of kidney failure caused by deferasirox, which is a potential risk that was discovered two years after deferasirox was marketed, Yang Rui did not even synthesize this drug, how to make a judgment.

From the perspective of future generations, deferiprone and deferasirox are re-examined, the latter is still better than the former, but the risk of kidney failure is a very strong negative item, Novartis did clinical trials back then, or it was lucky to pass, or conspiracy theories were covered up, and these uncertainties were avoided by Yang Rui.

It took several years to finally fail in the third phase of clinical trials, which is the rhythm of the company's bankruptcy.

Not to mention Sinovel's current third-party revenue of 10 million US dollars a year, even medium-sized pharmaceutical companies with annual revenues of hundreds of millions of US dollars often cannot afford the failure of phase III clinical trials.

In the field of pharmaceuticals where investment is rising exponentially, most pharmaceutical companies will not even touch the second phase of clinical trials, they prefer to sell drugs that have passed the first phase of clinical trials at a good price, and then let the large companies take higher risks and make greater profits.

After thinking for a long time, Yang Rui replied: "The drug made of LCL670 is more complex and the cost will be higher, and I think that patients in China, and most of the Diping patients, need drugs with lower prices." ”

"But the drug made of LCL670 will be more effective. Grace looked directly into Yang Rui's eyes.

"If we could have gone through a lot of complicated procedures to make this expensive drug...... I would still choose to deferrione, you may not have met Diping patients in China, many of them are not using deferoxamine, even when they need to deferoxamine, the high price will stop them. Yang Rui paused for a moment and said, "In China, in the current China, price is more important than efficacy, and cheap drugs can prolong the life of patients longer than highly effective drugs." ”

Yang Rui read and learned enough information from the information collected by the hematologist Yong Xiaodong, and at the same time, he also knew the past and present lives of domestic diping patients, so his answers were true and real.

Grace fell silent for a long time.

The lab fell silent for a long time.

Suddenly, Grace stretched out her hand, hooked Yang Rui's neck, and kissed him heavily.

Flaming red lips, intense and long.

"You are a true scholar, a fighter, and a benevolent heart. After Grace broke away from Yang Rui, she said softly.

But there was still silence around them, silence to the point of silence.

Eighty-four years of youth, youth, middle-aged and old people have never seen this.

Even Comrade Van Lunding, an Englishman, also had straight eyes, like a locust tree that had been struck by lightning.

……