"The price of sildenafil in North America is 7 US dollars, excluding the cost, we can get about five gross profits per pill, this is mainly because of the green stone horn to bear a lot of costs in the early stage, they want to take sildenafil global sales agent, they are willing to bear a little more......" Yang Rui held the report in his hand, did not open it, but repeated it to Director Hu.

Director Hu is the director of the Chemical Medicine Revitalization Office, which is a competent unit of Sinovel .

Of course, Yang Rui can also report to the Food and Drug Administration of the Ministry of Health and other departments, but that is unnecessary, and people are embarrassed to listen.

Director Hu listened very carefully.

What is going on with the new drug, before Yang Rui, there was really no experience in China.

Don't look at the number of drugs approved by the state every year, but, except for generic drugs, the rest are Chinese patent medicines. Chinese patent medicine can only rely on domestic money to make money, and it is the most boring money to earn.

In the sixties and seventies, the country still exported Chinese patent medicines to Southeast Asia, Hong Kong and Macao, but after the eighties, there were very few. The main reason can be said to be the influence of many cultural factors, among which the influence of the FDA is inevitable.

Before the FDA, the quality of drugs in Europe and the United States was not very good, eating the dead and eating the disabled was not common, and there were not many diseases that could be treated, and many common diseases were powerless, especially terminal diseases such as cancer.

However, after the 80s, the level of Western medicine in common diseases has obviously risen to a higher level. From the perspective of scientific research, it is the generation of scholars who grew up after World War II, especially those who grew up in the era of genetics, that the biological techniques studied have finally begun to be applied to the field of people's livelihood. For example, although the cancer treatment plan carried out by Dalbeko in the 70s failed, 1 billion US dollars was not a pure waste, and the research results produced by these funds were finally released one after another in the 80s and 90s.

With such a scientific research foundation, there is room for the West's strong politics to play out.

Around 90 years, Southeast Asian countries have established corresponding drug review mechanisms, and the previous play of traditional Chinese medicine is not easy to achieve.

For a leader like Hu Chi, he hates and fears words such as FDA and Western medicine.

This feeling is a bit like Chinese football facing the five major leagues and the World Cup, on the one hand, he is desperate to enter the game, on the other hand, it is not himself who decides to enter the game. In addition to desperately understanding the situation and issuing some useless orders, the rest can only be to publicize that football comes from Keju......

Sildenafil has passed the FDA review, which is equivalent to a player entering the Premier League giants, and if it sells well, it is equivalent to becoming famous, and Hu Chi naturally wants to know the details.

He wanted to know, so Yang Rui introduced.

He first talked about the review process of the third and fourth phases of the clinical trial, then talked about the post-negotiation with Pfizer, then talked about the contract and sales policy of Greenstone Horn, and then the performance of sildenafil in the market, as well as several modes of recovering funds.

Hu Chi listened ignorantly.

The Chinese in 90 years know too little about foreign countries, even pseudo-high-level officials like Hu Chi, and he does not understand the professional situation in the field of medicine.

After listening to it for a while, Hu Chi finally gave up, decided to start with the part he knew, and said with a smile: "In this way, you still earned it, hahahaha......"

"Earning is earning, and speaking of which, I want to talk about where the money goes. Yang Rui also said the goal of his trip.

Hu Chi nodded again and again: "The funds have to be spent to be valuable, you say." ”

"The Ion Channel Laboratory of Peking University is ready to participate in the genome project, and the instruments, equipment, personnel and training have been completed. "The Human Genome Project is an international cooperation, that is, a project between countries, so it needs to be discussed on a national basis. Of course, Yang Rui has already finished the preliminary communication, and there is not much left of the professional part, and the rest is some political and diplomatic work.

However, politics and diplomacy are also the most complicated part. In the context of international cooperation and confrontation, no one knows whether they will become bargaining chips in exchange.

The international situation in the 90 years was very unfriendly to China, and it was very different from the mid-80s.

When Yang Rui won the Nobel Prize, he was praised by the media everywhere he went, and there was even a voice within the Nobel Prize committee, hoping to give China a Nobel Prize and promote the development of China's democratic cause from the side......

But after 90 years, the voice of the media has completely changed, and everything in China is going to be wrong.

Yang Rui's cloning of sheep is almost always regarded as a threat......

This is the political correctness of the Western world, and it is what the various committees care about the most.

If it weren't for the fact that the pharmaceutical companies are really strong, the pharmaceutical system is really rich, the lobby groups are really powerful, and the mouth cannons really need to use it, the passage of sildenafil will be subject to various restrictions.

Therefore, Yang Rui is not very relaxed and casual about joining the Human Genome Project.

Hu Chi also knew the difficulty of this matter, and said in a deep voice: "You also know the current diplomatic situation, I can only say that I did my best." ”

"En......" Yang Rui rubbed his chin and said, "If necessary, we at Peking University can provide some help, such as funds and personnel." ”

With his current influence, it is okay to represent Peking University.

As long as a project like the Human Genome Project is won, the influence of Peking University will be greatly enhanced, which is a great thing that both sides are looking forward to.

Hu Chi didn't expect Yang Rui to say this, and couldn't help laughing: "As far as Xidi is concerned, they should also help." ”

"It's better to give some. Yang Rui generously gave money. Greenstone Corner has been lobbying in the United States, spending tens of millions of dollars, tens of thousands, or even hundreds of thousands of dollars on drinking parties, and holding seven or eight of them, which is enough to hold 800 flowing water banquets in China, and it has been three and a half years since he returned to his hometown.

A unit like the Ministry of Foreign Affairs is very happy for its subordinate staff, even if it doesn't want any gray income, saves a little travel expenses, and buys a little foreign specialties can make a lot of money, but for the unit itself, the cost of every business trip has to use foreign exchange, and it is really hard to say that it is rich.

Similarly, there are units such as the criminal police team of the police station, where employees are nourishing on weekdays, but when it comes to handling cases, they often drive thousands of miles to collect evidence, and the cost of food and accommodation for long-term squatting is not a small amount.

Yang Rui knows this, so he often donates to the police department in the jurisdiction. In the same way, it doesn't matter if you donate to the foreign affairs department.

If you don't count the plug-ins, if you analyze the difference between him and the scholars of the same era, except for Yan Gao, the main thing is that he is rich.

If you have to analyze it carefully, it is rich and generous.

Other domestic scholars, even if they get a large amount of money, because of their past experience, most of them will use the deduction and the noose, which is an era when everyone still regards thrift as a virtue.

Yang Rui doesn't have this habit anymore, and his scientific research has reached the peak, which is actually krypton.

If you want to improve any advanced skill, you have to spend several, tens, or even hundreds of times the money of the previous level.

In 1990, China was still accustomed to doing follow-up research, to put it simply, it was used to following the big guys, and there was no consciousness of breaking into the world by itself, so it naturally liked to consider cost performance when spending money.

However, being server first has never been cost-effective.

Although Hu Chi was not used to such a straightforward operation, seeing Yang Rui's insistence, he agreed to it, and turned his head and said: "In this way, you have to consider the issue of domestic competition." ”

This is his intention to mention Yang Rui.

Yang Rui is not the first brother of the year, and asked with a smile: "Have you received any news?"

"You know where I am, and there's always someone who will come and test it. Hu Chi first explained, and then said: "People who pick peaches are always indispensable." ”

"Do you think they can pick it up?" Yang Rui asked slightly seriously.

Looking at China, Yang Rui is not the only one calling for the Human Genome Project.

Don't look at Yang Rui's shouting about the Human Genome Project from time to time, and even shouting at the Nobel Prize site, but when the national team decides the order, it is never judged by the volume and number of voices.

It is reasonable for people to bring up the scholar who was the first to call for the Human Genome Project, or to mention the oldest qualified, or to bring a member of the faculty to take the lead.

The Nobel Prize is only an award, not a qualification, and the members of the Faculty are.

Moreover, such as Professor Cai, Wu Hongbo, and Academician Zhu, although their international reputation cannot be compared with Yang Rui, their domestic reputation is not weak at all.

When the time comes, the Human Genome Project will be established, and it will not be impossible to give Yang Rui a deputy team leader, and then hang the team leader high.

Of course, Hu Chi supported Yang Rui, so he specially reminded him, and said: "If you pay attention, there should be no problem, but you can't help but take it to heart." ”

Speaking of this, Hu Chi said: "You have participated in more meetings recently, to remind everyone, in addition, you can also mention the human genome project again, get a preparatory group or something." ”

Yang Rui said a little annoyed: "How can I have time to do so many useless ......"

The preparatory group or something is to line up to eat fruits, and to settle everyone else, everyone is happy, but they won't all come to grab it.

It is equivalent to making a promise to everyone, and then keeping a high position of one's own.

But Yang Rui was reluctant to do so.

The ranking of seats is not as easy as imagined, and it is not his specialty, the most important thing is that the Human Genome Project is to really do things, and when the time comes, a group of old men in their seventies and eighties, who will do the work?

Hu Chi asked, "What do you have to do lately?"

Yang Rui snapped his fingers and said: "I'm going to take a class, Sinovel also has to consider developing new drugs, the ion channel laboratory and Sinovel laboratory also have routine research doing, in addition, I also plan to make a medicine valley." ”

"Medicine Valley?"

"Concentrate some drug-related enterprises, just like a development zone, but by Sinovel privately, do not pursue short-term benefits, and there is no trouble for the development zone to take care of this and that, it is simply to concentrate on the industry, concentrate some enterprises, in addition, we give enterprises supporting housing, only rent but not sell, to reduce their worries. Yang Rui paused for a moment and said, "The loan amount given by the Bank of China is almost 10 billion, and it has to be used." ”

"Is it large?"

"Now it occupies a large area of Pudong, and Shenzhen@Zhen has also given a large piece of land. It can accommodate about a few hundred companies, and there is still room for it. Yang Rui paused and said lightly: "The construction of the factory is undertaken by the enterprise itself, but in order to attract the pharmaceutical factory to come, we have to undertake a large number of residential construction, and it is currently estimated that at least 500,000 workers must be able to accommodate it, plus the follow-up, that is, 1 million suites, the amount given by the Bank of China is just right." ”

Hu Chi's eyelids jumped: "Isn't the loan to be repaid?"

"There are still follow-up profits, and besides, isn't there a rent? If the units pay it, it will also save a lot of trouble. ”

"But...... 1,000,000 sets?"

"Build it slowly, don't be in a hurry. The loan given by the Bank of China is not unconditional, and they are willing to invest in infrastructure. If all of them are used to make new drugs and buy machinery and equipment, they will not be at ease. ”

"That's the same, but you've got a big plan. ”

Yang Rui laughed twice and said: "I originally put forward an idea, but the governments of the two places were too active, and they sold land cheaply and subsidized by policies, so there was no way to make trouble, and it got bigger and bigger." ”

"Then you have to be careful, don't miss the gap when the time comes. ”

"The Bank of China's loans are issued on a pro-rata basis in our dollars, and the risk is not very large. Yang Ruihan laughed twice, somewhat weak-hearted.

How much will the 1 million suites in Shang@hai and Shenzhen@Zhen be worth in 20 or even 30 years? Yang Rui himself is a little afraid to calculate, he can only say that if Huarui wants to develop new drugs or something in the future, the rent is enough.

There are quite a few state-owned enterprises that survive on rent, but they are not inferior to a private enterprise.

For Yang Rui, Medicine Valley is really to solve the current problem.

Bank of China's loans are to be spent, and not spent in too risky places, otherwise, people will also have to interfere, in this case, infrastructure investment is the best choice. On the other hand, Sinovel does need to have a centralized industrial base in big cities, with the hot sale of sildenafil, Sinovel has greatly strengthened its sales network across the country, and the brand has gradually become louder.

With China's industrial scale and consumer market, once involved in the production of various generic drugs, the industrial park of hundreds of thousands of workers really cannot be ahead of its time.

As for the 1 million residences, in this context, it is more to increase Yang Rui's personal satisfaction - they all know that the house is going to fly, so there is no reason to buy two more.

To this end, Yang Rui also asked to build the house as large as possible on the grounds of providing high-standard housing.

Hu Chi could guess Yang Rui's thoughts, and as soon as his mind changed, he returned to the previous topic, and said: "Since you want to make a medicine valley, it is better to do this, in the name of the Chemical Medicine Revitalization Office, I will promulgate the GMP standards you made before in advance." ”

"Enacted now?"

"The policies and regulations are ready, and if they are implemented on January 1 next year, the review can begin this year. This matter has always been promoted by you, and it just so happens that you also have to take the time to understand the situation of each pharmaceutical company, so it is up to you to arrest it. How about splitting up another committee from the existing GMP committee?" Hu Chi said as a matter of course, and expressed full respect for Yang Rui.

Yang Rui was surprised, but also saw the rolling murderous aura.

The GMP standard mentioned by Hu Chi is a hard standard for pharmaceutical companies, and if it cannot be passed, the result will be to shut down and transfer.

Historically, more than 4,000 domestic pharmaceutical companies were left in the end, including the newly built ones, which are equivalent to half of the pharmaceutical companies, facing the crisis of being swallowed up or going out of business.

The committee responsible for the standard review and its person in charge are equivalent to holding the power of life and death of all pharmaceutical companies in the country.

In this kind of full-range audit, even a prestigious company may be eliminated because of a certain shortcoming-Yang Rui looked at Hu Chi and didn't speak for a while, such a major decision must not be a pat on the head and suddenly thought of it.

Hu Chi deliberately pretended to be stupid and laughed twice, and said: "You are in charge of the GMP audit committee, and you immediately have a lot of power, and it is convenient to do any medicine valley, and no one dares to pick your peaches, right?"

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