"We already know that the structure of G protein-coupled receptors is a transmembrane structure composed of 7 A helixes, and not only that, but some of its receptors also contain extracellular N-terminal or intracellular C-terminal structures. Pen @ fun @ pavilion wWw. ｂｉｑUｇE。 infoThis makes the structure of G protein-coupled receptors extremely complex. ”

Yang Rui held the microphone and spoke slowly about his views.

At the bottom of the podium, nearly 300 scholars were seated, as well as corresponding academic media.

This was originally just a project application meeting for the 863 Project, but somehow, the scale increased from 9 judges to nearly 300 people.

In fact, Yang Rui knows what is going on, this is a project application for G protein-coupled receptors, if scholars in related fields are not curious, then China's academic community will collapse.

If you want to give a metaphor that conforms to public habits, in China in 86, making a project application for "G protein-coupled receptor" is like a project review meeting held by the space agency, and the project reviewed is "Sirius's landing and colonization plan".

Of course, everyone knows that Sirius landing and colonization cannot be achieved overnight, or even at all, but since the applicant is the famous "Yang Rui", even if it is to know what the future looks like in 300 years, everyone is still willing to listen to it.

In fact, it is really difficult to say who is difficult and who is easy to thoroughly study what is going on with G protein-coupled receptors.

Even if Yang Rui only takes a small step, it is enough for everyone to listen.

However, Yang Rui didn't just want to take a small step.

He held the microphone and looked at the crowd below, who may represent the highest level in China's protein field, and said in a clear voice: "Some structural biology studies have obtained low-resolution structures, allowing us to see the general trend of G protein-coupled receptors, but these structures are too rough and there are too many questions to explain." ”

"I want to explain some of the issues. Yang Rui was not arrogant, nor did he have the slightest sense of humility, and said: "The questions I want to explain are as follows: first, why are hundreds of different molecules in the same seven-stage transmembrane structure, the G protein-coupled receptor family, specifically identify substrate molecules as small as photons and as large as proteins, and these substrate molecules, whether in shape, property or volume, are very different. ”

"Second, I want to know, the problem of signaling at the receptors. ”

If Yang Rui said the first point, the scholars present could still laugh and watch him perform, but when they heard the second point, everyone was already talking about it.

Because Yang Rui fundamentally raised two different questions and different directions.

Studying the structure or studying the signal are two links, and they are also two levels of difficulty.

Those who do the structure will not run to do the signal, and the one who does the signal will not run to do the structure, although they are both content in the protein field, but they basically belong to two branches, and it is difficult to compare these two with each other, why do they do it at the same time?

Including the 9 high-level scholars who were judges, they were all frowning at Yang Rui now.

Yang Rui was gone.

Of course, he knew that the two problems of structure and signaling were very difficult.

In fact, as long as you make any of them, you have the potential to win the Nobel Prize.

The combination of the two is a complete Nobel Prize - according to the Statutes of the Nobel Foundation, the Nobel Prize can be awarded to three people at the same time, and in Section 4 of the Statutes, it is stated that "the prize may be awarded to two pieces of work, each of which must be worthy of the award, and if two or three persons have jointly completed a work worthy of the award, the prize shall be awarded to them at the same time." However, in any case, no award can be given to more than three people at the same time. ”

Before the 80s, or earlier, before the 60s, the Nobel Prize was often awarded to one or two people, but with the development of science and technology, and with the increasing importance of the Nobel Prize, it has become the norm for three people to be awarded.

For example, Yang Rui is now working on the structure and signal of G protein-coupled receptors, which should have been shared by American scientists Lefkowitz and Kebilka.

But that was in 2012.

Since Yang Rui has chosen the mode of research in advance, he naturally doesn't want to play any more sharing mode.

In addition, the structure and signal are made together to give a general understanding of G protein-coupled receptors, which are indispensable.

If Yang Rui only does one of them, he still doesn't know when he will win the Nobel Prize.

G protein-coupled receptors are different from other fields because they are so difficult, so accumulation is needed, but sometimes it depends on luck and inspiration.

Therefore, the Nobel Prize in 12 years, the Nobel Prize in 02, and even the Nobel Prize in 92 years are not too far away, at least for Yang Rui, it is not an insurmountable distance.

Of course, the odds of winning a prize are also huge.

The Nobel Prize in the normal point is normal to wait for ten years, eight years, or twenty years to win the award, and the unlucky one waits until the lights go out and does not wait for the award, and the faster one is like PCR, which usually has a chance after a few years.

However, the G protein-coupled receptor is amazing, and in the case of the 12-year version, the results will be obtained in 11 years, and the award will be given in 12 years.

No way, this thing is too royal.

Of course, this does not mean that making G protein-coupled receptors will definitely win the award the next year, it can only be said that it adds another weight.

Brushing the Nobel Prize is the same as playing a god costume.

You know that the boss will come out of the god costume, the ultimate boss is a high probability, the big boss is a small probability, and the small boss has a chance, so the correct way to brush an ultimate boss and then look at the face, but to pile up the boss and pile up the corpse mountain, and the god costume will fall into your hands after all.

Yang Rui is not very confident in his luck, but he is still quite confident in his ability to brush the boss.

After speaking a few more points, Yang Rui returned the microphone to today's host, who is also the recommender of the project, Academician Zhu.

"Thank you, Comrade Yang Rui, next, if you have questions, please ask questions. Academician Zhu's voice was lazy, and his eyes were curious on the faces of a group of people.

He wondered how many people really understood.

The judges sat up straight in unison, and several people also made noises at about the same time.

"You go first. ”

"You ask first. ”

"You please. ”

Several people gave in again and again.

After that, Professor Qian, who was sitting in the middle of the judges, said, "Yang Rui, your plan looks good, is it a little too grandiose?"

"It's a big project, but I'm confident that we can complete it through the Peking University Ion Channel Laboratory and prove that the Ion Channel Laboratory is a world-class laboratory. ”

Wow.

The scholars in the stands began to talk again.

Yang Rui just nodded slightly, looked at Academician Zhu, turned around again, and said: "The Ion Channel Laboratory of Peking University has raised 6 million US dollars, as well as 2 million yuan of funding, and this time, the total funding of 3 million yuan applied for the 863 plan is also to enhance our strength......"

Yang Rui was sharp, and he didn't want to be modest.

Stand on the royal road and rush forward, everyone will see you, no matter how cowering you hide, you can't hide.

And the edge of the angle of attack with $6 million is really something that many people can't resist.

Professor Qian couldn't help but sit down quietly.

If he asks questions now, he will only bring shame upon himself.

"Next, is there any other question?" Academician Zhu asked softly.

The nine judges shook their heads in unison.

"Then let's vote now, and those who agree to approve the project and the amount requested, please raise your hand.

The nine paws were raised in unison.

"Okay, I announce that the first project of the National High-tech Research and Development Program, the structure and signal of G protein-coupled receptors, has been officially approved, and the person in charge is Yang Rui of Peking University......" Academician Zhu did not finish speaking, and the applause rang softly.

The louder it is, the louder it gets, the louder it gets.