The number of candidate compounds is decreasing day by day. Pen & Fun & Pavilion www.biquge.info

From the initial 30 species, to more than 20 species, to more than a dozen, until there were 13 compounds left, the reduction rate was reduced.

The compounds that were eliminated in the early stage were mainly serious reactions in animal experiments. In fact, the new drug application rules of various countries are similar, but if there is a serious reaction in animal experiments, it is not allowed to enter clinical trials, which is equivalent to a compound being eliminated.

It's a veto, but from the point of view of the pharmaceutical companies, it's the easy part.

Because compounds that have already been rejected will not incur additional costs.

On the contrary, the remaining 13 compounds will continue to incur costs in the process of further animal experiments.

It is fitting to describe this process as spending money like water.

Batches of mice, rats and pigeons were orally dyed with iron, each of which was given a candidate compound and subjected to a variety of tests.

The cost of various chemicals and instruments alone is more than 10,000 yuan per day.

Huang Mao and others did not personally participate in the research of the drug group, but they were also frightened when they watched from the side.

Seeing that it took them a week to reduce the number of candidate compounds from 13 to 12, Huang Mao couldn't help but ask: "With this kind of progress, wouldn't animal experiments take a year?"

Because Grace was there, Huang Mao was in English, and the former immediately replied: "It's normal to do animal experiments for a year. ”

Huang Mao calculated that the average research cost of more than 10,000 yuan per day is more than 4 million yuan, and the cost of animal experiments for a year is definitely more than 4 million yuan!

Although I have long known that the development of new drugs costs money, the feeling that the money is flowing in front of my eyes is even stronger.

Huang Mao couldn't help but say: "Our Huarui experiments have always exceeded the average speed, and you can't really do it for a year." ”

Grace tilted her head and thought for a while, straightened up and stretched her waist by the way, and after revealing her beautiful figure, she said: "Internationally, there are an average of ten medicinal chemists and two or three biologists involved in the laboratory that develops new drugs...... We have now, I'll do the math, I'm a medicinal chemist, Yang Rui and Wang Xiaoyun, two biologists, so, you're right, we can't really do it for a year, it's more likely to be five years. ”

Huang Mao's mood of wanting to complain can almost fill the entire laboratory: "Aren't you in a hurry?"

After a long time, Huang Mao held back such a sentence.

"The lab can't afford a medicinal chemist, what does it have to do with me. ”

"Wait five years, don't you waste five years too? Huang Mao didn't understand it even more.

"No, five years from now, there will not necessarily be other pharmaceutical companies that will do deferiprone, and since we have started animal experiments, we must complete it, otherwise, it will be irresponsible to other pharmaceutical companies and thalassemia patients. "Grace's thought circuit is peculiar.

Huang Mao didn't react for a long time, and asked, "Why?"

"Are you asking......"

"The irresponsible part. ”

What Grace means is that if we stop halfway through animal testing, other pharmaceutical companies may think that our animal testing is going so bad that they abandon the deferiprone project altogether. Yang Rui listened to their conversation, interjected, and said: "We are in a good state at the moment, and no pharmaceutical company will abandon the project at this stage, so unless we encounter other force majeure, animal experiments will definitely be completed, and if it is not completed, other companies and even the FDA will consider this situation, and in case of litigation, the lawyers will definitely find out the root cause." ”

Huang Mao understood, changed to Chinese this time, and asked, "Is it good to finish?"

"The project that passed the animal experiment can already be sold at a good price. ”

"How do you sell it?"

"There is a dedicated market. "Yang Rui actually doesn't know very well, where did he have the opportunity to play this kind of game like mergers and acquisitions before.

Huang Mao's eyes widened and asked, "Is it expensive?"

"It's not going to be too cheap, just for this expense. Yang Rui pouted.

Huang Mao also reacted instantly, as far as the experiments conducted by Sinovel Labs in a relatively cheap way are concerned, it will cost 20 million yuan in five years, and if a foreign company hires 10 medicinal chemists and two or three biologists, the annual salary will have to be millions of dollars, not to mention other costs.

"It's just too long. "If it is to earn back tens of millions of yuan in five years, Huang Mao does not think that there is much income, there are too many factories with annual profits of one million or tens of millions in China, and Sinovel Laboratories now spends more than one million dollars a year, especially in the ongoing PCR lawsuits, American lawyers are charging fees, and 20 million yuan is simply not enough to fill the hole.

Thinking about it this way, when it was time to eat at noon, Huang Mao deliberately sat beside Yang Rui, smiled at Grace at the same table, and said in Chinese: "Yang Rui, otherwise, you don't spend all your time on ferrite kene." ”

"Why?" asked Yang Rui strangely.

"Five years!" Huang Mao sighed and said, "Yang Rui, don't blame me for what I said, don't look at your current efficiency and good grades, you think you will be like this in the future." No way, you're 20 years old, that's the age to get results. Why does our country want to set up juvenile classes? It is to make the scientific research life of scientific research personnel a little longer, and to start conducting research at the age of 20, like you, the high-yield period can last until the age of 30, 35, and even more powerful, it can last until the age of 40, and these 20 years are twice as long as that of ordinary scientific researchers. ”

After a pause, Huang Mao said again: "Think about it, you'd better do 20 years of scientific research, do you want to spend five years doing ferrenone? I'm not saying that ferrenone is not important, but as far as the current animal experiments, I can do it, Lao Tu can do it, Wang Xiaoyun can do it, why do you waste your golden time on this, how much can you do in five years?"

Yang Rui was stunned by Huang Mao.

In his drug group, there are only Wang Xiaoyun, Wei Zhenxue and the self-volunteering Grace, in fact, because the animal experiment is relatively simple, he is not willing to waste the time of the calves that he has brought in with great difficulty.

People such as Huang Mao, Li Wenqiang and others are all people who have the ability to publish cell-level articles in the future, so why use them for simple manual work.

Yang Rui forgot how much time he had to spend on this.

Careful calculations show that the entire animal experiment has only been carried out for two weeks, but for a researcher, two weeks is a lot.

"Just take a vacation, change your mind. Yang Rui smiled and explained to himself and Huang Mao at the same time.

Huang Mao was dumbfounded.

Wei Zhenxue, who was sitting not far from this table, was originally eavesdropping with his ears pricked up - and only he could do such a thing - coughed at this time and said: "People are different, some people take vacations to play outside, some people take vacations to go home to sleep, and some people take vacations to pull the spine of a guinea pig......"

"I didn't even move a guinea pig. Yang Rui explained again.

"I'm wrong, it's someone who likes to watch people pull the spine of a guinea pig on vacation. Wei Zhenxue laughed, consciously saying perfectly.

Yang Rui was speechless, and suddenly felt that he had a perverted tendency. After thinking about it, Yang Rui thought again, if you don't change your state and don't live there, it's actually not a big deal.

"I'll take another week off, and if that doesn't work, I'll think about change. Yang Rui stood up as he spoke, gently patted Wei Zhenxue's neck twice, and then put it still.

Wei Zhenxue only felt goosebumps all over his body, and the warm people on the back of his neck were cold.

Yang Rui's thumb pointed at Wei Zhenxue's neck bone, thinking about how to speed up the progress of animal experiments.

As a simple permutation and combination of elimination experiments, the progress of animal experiments can only be changed according to the amount of resources in many cases, and the space for technology to play is very small, because no matter how good the technology is, you can't see the changes of a compound in the human body or animals.

If you don't try it, who knows how well the compound works, whether it will be metabolized or enriched, whether the metabolic pathways will be as expected, and whether the metabolites will be beyond imagination......

Yang Rui knows.

……