The popularity of the Nobel Prize is still very high, especially after the publicity in recent years, it has become even more imposing. Pen × fun × Pavilion www. ｂｉｑｕｇｅ。 ｉｎｆｏ

Matsushima Heng specially paid attention to the expressions of the Chinese around him, and replied cautiously: "Mr. Yang Rui, as far as I know, the initial funds of the ion channel laboratory have been almost spent. In my opinion, only with our investment can your lab complete the conformation experiment of G protein-coupled receptors, and if you aim for a complete conformation, not to mention $6 million, even $20 million may not be able to do it, so your hypothesis is based on results that you can't get yourself. ”

"Our upfront $6 million is really costing about the same. Yang Rui paused and said, "You just said that you will invest another $6 million to work with us to achieve 50% rough conformation?"

Matsushima Tsuneshi immediately confirmed: "That's right, that's what I expected. ”

In terms of rough conformation, this thing really isn't rough.

Most laboratories or scholars can't do the phased results in one go before they are published, and those who dare to do so are the top labs, and they have to fight for luck.

Therefore, most researchers publish as much as they can do.

Doing conformation is like drawing a ruler, you have to know the most basic constraints to make a conformation, and the constraints are made by a lot of experiments.

The so-called rough conformation is to get incomplete constraints, such as 30%, 50%, 60%, 90%, and so on. However, the so-called 50% restriction of Matsushima Heng is not to make 50% from scratch, but to make 50% on the basis of the existing one, which is indeed very difficult from his point of view.

However, in the ion channel laboratory, which has invested a lot of money and time, especially in the ion channel laboratory shrouded in Yang Rui's golden finger aura, it is not the same thing.

Before Gu Qiang's invention of the "cauldron stew", 50% rough conformation was still difficult, and after that, it was meaningless for the ion channel laboratory.

With a visual explanation, if the conformation of G protein-coupled receptors is a puzzle, each puzzle is equivalent to eating a little raccoon instant noodle set card, eating a pack of instant noodles, you can get a card, the card may be repeated, maybe it is different, collect half of the cards, it is called 50% rough conformation, and all the collection is equivalent to the completion of the conformation.

At the beginning of the ion channel laboratory, like other laboratories, they bought three packs of instant noodles every day, hoping to get the card they wanted by luck, but it turned out that it was not possible, so each laboratory began to show their magic powers, and created many theories, such as instant noodles with the last letter of 5 are easy to produce good cards, pinching instant noodles that are easy to break are easy to produce good cards, and the instant noodles of Lao Wang's next door are easy to produce good cards, and so on.

Among the various theories, the ion channel laboratory has chosen the most correct theory - buying 30 packs of instant noodles a day is easy to get a good card.

In fact, there are still many laboratories that choose this doctrine, but most of the laboratories that are qualified to choose this doctrine are composed of super foodies, and you have to eat 30 packs a day.

In the era when 20% of the rough conformation is not completed, most of the laboratories are in a period of recuperation, some can insist on 30 packs a day for convenience, some can't, buy 20 packs a day and cooperate with some other theories, there are also some.

Yang Rui saw this loophole, and before others reacted, he started with 30 packs, and quickly transitioned to 40 packs, 50 packs, and 100 packs...... It's not that the food power of the ion channel laboratory is higher than that of other top labs, but because Yang Rui has invented a new method: just take the card and lose the noodles.

This practice, when it was rapidly increasing to 200 packs, encountered a bottleneck - there is only so much instant noodles that the store buys every day.

Later, Gu Qiang's invention of a pot of stew, which is equivalent to the wholesale tactics of instant noodles, is a very simple and crude method, throwing away the middleman of the commissary, directly connecting with the wholesaler, and increasing the purchase of instant noodles in the ion channel laboratory to 1,000 packs per day......

And so, it took months for the Ion Channel Lab to collect all the cards.

Matsushima Tsune's 50% rough conformation is still based on buying 30 packs of instant noodles a day, and assuming a 50% rough conformation is naturally a big goal.

For the ordinary students in the class, it is also very cool to be able to collect half of the cards.

Matsushima is even more willing to pay more for this goal, and he is very open: "If you are not satisfied with this amount of funds, we can also talk about it." ”

Yang Rui smiled and said, "If you calculate it this way, to achieve 50% of the rough conformation, your expected cost is 12 million?"

Matsushima Heng thought that Yang Rui suspected that the expenses he reported were too big, and said with a smile: "50% rough conformation, 12 million US dollars should be good." It depends on the progress of what you are doing now, however, I estimate that 12 million is about the same, depending on the state of your laboratory, all kinds of instruments are also available, and the reserves of our Matsushima laboratory are not weak, and the next thing is the problem of expanding the scale of the experiment, no matter how bad luck is, within 15 million US dollars, it should be able to be made, that is, it will increase by another 9 million US dollars......"

"50% rough conformation, worth $15 million?"

"When we work together, when we calculate cost and value, of course, we can't just count the cost. "We expect to invest two associate professors, 10 to 15 assistants, and the full support of the University of Tokyo, so I think it's appropriate to double the value at $30 million." ”

"50% rough conformation, worth $30 million?"

"That's right. ”

"What about the rough conformation to 90%?" Yang Rui was like a diligent hunter, silently digging a pit.

Matsushima Heng was not well informed, so how could he guess what the current state of Yang Rui and the ion channel laboratory was, but he laughed: "Although I said that 6 million US dollars can complete 50% of the rough conformation, but 20 million US dollars, it is difficult to make 90% of the rough conformation, Mr. Yang Rui, our goal should be realistic, right? Make 50% rough conformation first, and then talk about the rest?"

Matsushima still has a certain degree of trust in Yang Rui and the ability of the ion channel laboratory, otherwise he would not have rushed to China, but his goal is not necessarily 100% clear conformation, 90% is very good, and 50% is not bad. Not to mention, now that he is still in a state of conversation, his tendencies are even stronger.

Yang Rui smiled and said, "Isn't this still a discussion?"

Matsushima Heng didn't believe Yang Rui's words, and even guessed that he wanted to tell the leaders himself.

However, Matsushima Heng did not mind letting the leaders present understand the value of this plan, anyway, the Chinese side could not afford to spend a large amount of foreign exchange for G protein-coupled receptors, and he preferred to exaggerate the difficulty.

Matsushima Heng thought for a moment and said, "If Mr. Yang Rui's goal is 90% rough conformation, we can invest up to 20 million US dollars, and Matsudo Lab will also increase investment, but to be honest, I'm not sure that this is enough." 90% of the rough conformation will take more effort and time, and at this point, it may be necessary to bring in more investors, and I hope that the Chinese side will also have a certain amount of additional investment, not necessarily foreign exchange, but also the renminbi. ”

He said half a sentence, the translator followed half a sentence loudly, and the leaders listened and nodded again and again.

China in the 80s was indeed short of money, but the central government was not short of RMB, no matter which unit it was, the RMB could be used.

If there is really 20 million US dollars invested, it will definitely not be allowed to be swallowed by Peking University, everyone wants to invest, if you can invest in RMB and then divide foreign exchange, it will be better

Yang Rui just smiled and continued to ask: "In this case, the investment will exceed 26 million US dollars, and the value will also be doubled to 52 million US dollars?"

"You're talking about the value of 90 percent rough conformation? That's not all. Matsushima Heng laughed, looked at the leaders around him, and explained: "90% of the conformation consumes time, and the risk is very large, if any laboratory can make it first, the value of 60 million is too little, 70 million is not an exaggeration." ”

"What about the value of 100% clear conformation?" Yang Rui asked, "This is a Nobel Prize-level achievement, how much is it worth, is it worth 100 million US dollars?"

Matsushima Heng frowned imperceptibly, and said: "If you make a 100% clear conformation, you will naturally be eligible to win the Nobel Prize, but the probability is not very large, Yang Rui, we are now cooperating with China and Japan, and it is enough to temporarily set the goal at 50% of the rough conformation." ”

Liang Rui always paid attention to Matsushima Heng's expression, for fear that such a large amount of foreign exchange investment and cooperation would run away, and hurriedly said: "Yang Rui, don't think too much, even if you make any results, people will give millions or even tens of millions of dollars, and cooperation should be done." Don't look too far now, take it one step at a time. ”

"There's no way to do it step by step. Yang Rui spread his hands.

Liang Rui frowned: "What do you mean? Are you trying to reach the sky in one step? Professor Cai, your Peking University laboratory is too ambitious. ”

Yang Rui's secondary temperament today is too strong, so much so that Liang Rui also asked Professor Cai to suppress it, so as not to be pulled up and entangled.

Yang Rui didn't give him a chance to jump out of the trap, raised his voice, and said: "It's not that we want to ascend to the sky in one step, it's that we don't need their money now." ”

Without waiting for others to wake up, Yang Rui continued: "Don't say 50% rough conformation, or 90% rough conformation, we have already made 100% clear conformation, as long as they pay 6 million US dollars, they want to take away 100 million US dollars worth of projects, and hang their own names, this business is too cheap." Director of the book, is it appropriate for you to judge the judges?"

……

On the fifteenth anniversary of Dianniang, I did a fan title collection activity, which felt very good. However, it was very difficult to think about the name of the Bird Dolphin fan group, and after thinking about it again, I decided to expand it, solicit it from readers, and give small gifts to some of the participating students, the name that was finally chosen, and a mysterious gift. In order to facilitate statistics, students who participate in the event are requested to leave a message on the official account of Bird Dolphin (znc100), and the specific participation method will also be explained in detail here.

……