"Show me your lab logs. Pen "Fun" Pavilion www.biquge.info"

"How are you doing so far?"

When Yang Rui came to the laboratory, he asked all the way. He rarely does this, in fact, very few heads of large laboratories do, on the one hand, because of the lack of time, and on the other hand, the lack of capacity.

There is no time, the head of any large laboratory is a busy guy, they either spend their time in the laboratory, or spend their time fundraising, and if anyone wants a senior laboratory leader to revolve around him all day, then he had better be the Flash or something.

Lack of ability is another helplessness, the work of the laboratory is no longer a known job, no matter how easy the work of the scientific research dogs is, it is also spinning on the edge of the unknown world, if the person in charge of the laboratory can explain all the problems, he does not need the scientific research dogs to do experiments desperately, so the unknown problems encountered by the scientific research dogs are also unknown problems for the laboratory leader, maybe the latter is more experienced to solve these problems, but it also takes a lot of energy and time.

Therefore, the more high-end the laboratory, the less the laboratory leader will give hands-on guidance.

Give systematic training, point out the direction of development, provide cutting-edge information, and have high-level senior brothers, who are basically the heads of high-end laboratories, can provide the most valuable things. Of course, if you consider the worldliness a little more, the experimental resources and social resources of high-end laboratories are more abundant, which is also a good thing.

However, Yang Rui is not your average lab leader.

In the face of the unknown scientific world, the heads of other laboratories may be like scientific research dogs, waiting for the results of exploration with black eyes, and at best, they are just holding candles and looking for them.

But for Yang Rui, the world of science in the 80s was brighter and clearer than the playground under the noon sun.

Therefore, he is indeed capable of doing hands-on guidance.

However, in the past, Yang Rui would not do this, mainly because he was not confident enough, and in addition, he did not know enough about details, especially details. It was only after several years of high-intensity laboratory life that Yang Rui had a high level of detailed domain control.

The most important point is that there was no need to teach scientific dogs by hand.

Just like the enemy's tanks have only 40 mm of armor for defense, and our side already has anti-tank weapons with 60 mm penetration, it is obviously not a top priority to produce anti-tank weapons with 100 mm penetrating power.

Until now......

If the scientific defense system encountered in the study of PCR is 40 mm armor, the defense system of G protein-coupled receptors is about 400 mm of armor.

The defense level of PCR is the defense level of Japanese small tanks, and the defense level of G protein-coupled receptors is a proper sea battleship.

And the three-dimensional structure that Yang Rui is trying to do is almost equivalent to the core part of the battleship of G protein-coupled receptors, and you can't buy 400 mm of reinforced armor, and you can't buy it......

In the face of such a strong enemy, it is not possible not to upgrade the scientific research dogs.

Especially when encountering a scientific research dog like Wu Qi, since he wanted to develop talents and resources, Yang Rui decided to start with the most powerful.

Yang Rui is an experimental record, a book of experimental records looked over, pointed out the mistakes, and casually pointed out the direction.

"Control the temperature of your reaction. ”

"You have to think more about the use of solvents, why should the concentration be put at this value? Do you have to use these types? What is the basis for the selection?"

"Big mistake, start over!"

Yang Rui spent a morning killing the laboratory.

The students in the laboratory were just that, and several professors who had joined the laboratory not long ago were shocked by Yang Rui.

Since His Excellency Liebig, the teaching mode of high-end laboratories has not changed much in the past 100 years, and the Giessen laboratory has always compressed theoretical teaching to a minimum, instructing students to do hands-on experiments most of the time, and using a three-step approach to train them. The practice of handing over the teaching of beginners to skilled students is exactly the same as that of graduate education in later generations.

Now, Yang Rui is doing the opposite.

When he arrived at Wu Qi's side, Yang Rui stood still and didn't leave.

"There is no problem with the operation, what do you think of the results of this experiment. After watching Wu Qi finish a set of experiments, he asked.

Wu Qi just straightened his waist, breathed a sigh of relief, and felt overwhelmed, so he quickly turned his brain and said, "If you analyze it from this substrate experiment......

"Don't analyze from an experiment, you have been doing experiments for so many days, what do you think?" Yang Rui instantly interrupted Wu Qi's words.

Wu Qi was stunned for a moment, and couldn't help but hesitate, needless to say, the difficulty of analyzing an experiment and analyzing a bunch of experiments was needless to say, and he was not prepared to let him say it all at once.

Yang Rui waited quietly for a few minutes, he had higher expectations for Wu Qi, so he also made super high requirements.

However, Wu Qi didn't seem to have entered the state yet, and his head was lowered as if he were a statue.

Yang Rui didn't feel disappointed, but he felt a little surprised.

"...... like this"

"I think ......"

At the same time as Yang Rui spoke, Wu Qi just raised his head to speak.

"Let's talk about it first. ”

"Let's talk about it first. ”

The two of them spoke in unison.

Yang Rui couldn't help but smile, shook his head, raised his chin, and gestured, "Did you come up with the result?"

"A little bit of a ...... idea," Wu Qi didn't dare to say too much.

"You say. ”

"Yes. Wu Qi thought for a moment before saying, "I have been doing experiments recently, and I am more concerned about hydrogen bonding. ”

Hydrogen bonding is a common intermolecular force, and in junior high school, the value is basically equal to a "-", but in advanced research, hydrogen bonding is very varied.

Yang Rui didn't expect Wu Qi to say "oh" from this point of view, and said, "Tell me about it." ”

"Yes. Wu Qi paused again and said: "I have read some literature and believe that the directionality and saturation of hydrogen bonds are the driving force that causes the association of acceptors and substrates, and then the formation of complexes, as well as an important reason for molecular recognition. ”

Yang Rui nodded slowly: "The G protein-coupled receptor we are doing now focuses on molecular recognition. ”

"Yes. So I've been focusing on hydrogen bonding lately, and I think that if you take into account the hydrogen bonding factor in the classification of substrates, you should be able to screen out some substrates. These substrates should have a higher chance of being used in conformational analysis. Wu Qi said very slowly, just a paragraph, which was also broken up into several sentences by him.

However, what Wu Qi said is really worth thinking about, including Yang Rui, and he also listened very seriously.

In the case of restricting funds, resources, and scientific foundations, the probability of the former appearing is greater than that of the latter, but after the various restrictions are lifted, the possibility of the latter appearing increases.

Scholars need to make the conformation of G protein-coupled receptors, and they have chosen some methods, which do not include hydrogen bonding paths, and later, the conformation of G protein-coupled receptors is completed, and whether there are other methods or ways to reach the goal of conformation, it will lose practical significance.

As for now, Yang Rui feels that he can take a walk.

Anyway, he has so many scientific dogs under his hands, and it would be nice to send a more astute one to explore the way.

Thinking of this, Yang Rui nodded slowly and said, "You write a report to me, explain your thoughts, will you write this kind of report?"

"I will. Wu Qi nodded excitedly, and directly submitting a report to the director of the laboratory is a step to the sky for a scientific research dog.

Yang Rui nodded and said, "I'll give you a separate fund, 10,000 yuan, after the report is written and passed, you will try the hydrogen bonding method alone, if you can do it, you will be allowed to sign the paper separately." Of course, if that doesn't work, then go back to the usual route. ”

"I'll do it. Wu Qi pressed his mood, full of the heroism of a confidant.

……