Yang Rui quickly set up a drug research group in the Huarui laboratory, and selected Wei Zhenxue to cooperate, plus two scientific research Wangs, even if he set up a grass platform team to remove ferrite. Pen | fun | pavilion www. ｂｉｑｕｇｅ。 ｉｎｆｏ

Including within Sinovel Labs, everyone is not optimistic about Yang Rui.

If it weren't for the great prestige he had accumulated over the past year, his colleagues in Sinovel Labs would have opposed Yang Rui's decision like Xu Zhengping.

During this time period, opposition is the normal response.

Pharmaceutical research itself is a very professional field, and in the original drug company, those researchers who spend half their lives on a drug are basically god-like beings in the subdivision and specialization field. After Reagan's bill, universities and research institutions at all levels, some of which have jumped from academia to industry, have greatly enriched this field and raised the threshold for pharmaceutical research infinitely.

Not to mention the grass platform team, even if it costs millions of dollars to form a team, it does not dare to be called a dream team in the field of drug research.

Scholars in the academic world naturally look down on researchers in the industrial world, but if you really want to talk about it, the Nobel Prize winners in the industrial world are not necessarily much less than the academic community, especially between the 80s and the 90s, it is popular for award-winning scholars to change jobs, because the big pharmaceutical companies are too ruthless in opening salaries, often millions of dollars in offers, and the tenured professors with an annual salary of 70,000 US dollars are difficult to sustain。

However, super pharmaceutical companies such as JieliZeneca have never been afraid of the challenge of small pharmaceutical companies, and their biggest magic weapon is to acquire, and use 350 million or even 100 million US dollars to pocket all promising small pharmaceutical companies - even if they can't do it, they will buy out the products of small pharmaceutical companies directly.

For example, the PCR technology of Stem Company, if Yang Rui did not intervene, would have been resold at a price of 300 million US dollars, and several Nobel Prize winners in Stem Company also used this money to improve their lives and work in other companies......

All in all, modern pharmaceutical companies are the enterprises with the highest technical requirements, and they are also the enterprises that need technology the most, in contrast, the industry outside the pharmaceutical companies has been basically separated from the academic world, such as the experts in the academic research machinery, who are basically stuck in the physical world and cannot extricate themselves, those who do metallurgy are doing materials, those who do materials are tossing microscopic crystals all day long, and those who are doing wafers are checking hygiene, and computer professors have long been unaware of what they should do......

Only the R&D of pharmaceutical companies can be used by Nobel Prize-level scholars throughout the whole process from theory to production, in other words, the world's top technology can be directly used in end products.

This process is naturally extremely complicated, and sometimes even depends on luck, for example, deferiprone is an iron chelator, but no pharmaceutical company's research team will think about saying "I'm going to find an iron chelator", or "invent an iron chelator", he can only obediently wait for an iron chelator to be discovered, and then think about how to make it into a drug.

The drug of ferriprone can only be used after the discovery of ferridone.

This is also the first step in the pharmaceutical process, the selection of drug targets.

After the target, there is more troublesome research on drug synthesis and pharmacokinetics.

In order to pass the examination and approval of the drug regulatory bureaus of various countries, all the steps must be carried out step by step and strictly recorded, and if you go beyond the thunder pool, you will face the situation that clinical trials will not be approved - unless the researcher uses himself to do the experiment, otherwise, the development of a new drug is considered to be over.

Yang Rui actually didn't know the specific process, but he was not in a hurry.

He is not a person with a professional background in medicinal chemistry or drug synthesis, and he doesn't understand the process, so what does it matter if he doesn't understand the process, his current focus is to synthesize deferiprone first, and then see the effect if, if the effect is good, it will be too late to find someone.

Of course, with Yang Rui's self-confidence, he asked Li Zhangzhen to find someone at the same time.

Others don't understand Yang Rui's self-confidence, but Wei Zhenxue doesn't care at all, he just needs to have an experiment to do, the more lofty the experiment, the more Comrade Wei Zhenxue likes it.

The two of them seem to have returned to the time when they were in Seaburg Middle School, no matter what others say or do, they just stuff their heads and do their own experiments.

"The fourth experiment of deferiprone was ...... with the direct reaction of 3-carboxy-2methyl-4 pyranone and methylamine" Yang Rui made a record of the experiment and immediately started the experiment.

Wei Zhenxue helped beside him, and said: "You can't do it like this, if you react directly, you can do it, people haven't already synthesized iron ketone." ”

"It's because people haven't tried too much before. When Hider first discovered ferriprone, he only did research on iron chelation, but did not carefully study the synthesis of deferiprone Yang Rui shrugged his shoulders and said, "Hider uses the methods of predecessors, and the yield is too low. ”

"It's too low, I don't think he knows how to synthesize compounds. Wei Zhenxue laughed and said: "The yield rate is less than 1%, it is not pure enough, and I don't know how many people will be poisoned when it is made into medicine." Poison Hider, what's the name?"

Yang Rui didn't say anything, still looking at the test bench.

Wei Zhenxue boasted to himself: "It's not that I said, I myself am a chemistry major, I was a person who has published many papers in coal chemistry back then, I don't know how the level of hider is, as far as the method he uses, it really can't work." It's even worse for you to use this, it's better to listen to me, let's start with the protection of the carboxyl group, find a way to methylate, and then deprotect the protecting group, it is estimated that we can get the ...... of deferiprone

"It's also a way. Yang Rui was noncommittal.

"I'm more reliable this way. "Others won't talk to Yang Rui like this now, only Wei Zhenxue has not changed his original intention for many years.

Yang Rui smiled and said: "It's indeed more reliable, but it's also more troublesome, let's first consider whether the simple method can be made, and then consider the complex method." ”

"You said the opposite. ”

"I can't care so much, let's do this first. Yang Rui replied casually.

The method that Yang Rui is using now is the chemical synthesis method invented in 94 years, which is the most inexpensive synthesis method.

Needless to say, it was a substitute method in the 60s, and it basically could not be used in industrial production, as for the method proposed by Wei Zhenxue, if it was changed a few more, there would be a chance to synthesize iron ketone, but Yang Rui was not ready to use it.

Because he only needs one way to produce deferiprone on the line, as a researcher who is not very familiar with chemical synthesis, it is normal to get a simple and convenient chemical synthesis method by hitting the big luck, but it is impossible to get more than one if the big luck is hit.

Therefore, Yang Rui was in place at one time, and simply used methylamine to carry out a direct reaction.

However, according to normal chemical thinking, direct reactions such as one-time generation have never been easy, and in the words of scholars, they are unreliable.

Generally speaking, everyone is more inclined to find a simple way to produce first, and then gradually improve, just like coenzyme Q10, Yang Rui has transformed three stubbles, which has not yet been put in place, and Jielikang is also very satisfied.

Unfortunately, deferiprone is not as profitable as CoQ10, and Yang Rui prefers to build a pharmaceutical company through this work, so he considers the focus of his work on clinical trials and the application process rather than the pharmaceutical process.

Therefore, after doing a few wrong experiments, Yang Rui couldn't help it, and he was even more lazy to upgrade step by step, so he took out the technology that a certain scholar only came up with 10 years later, and let those gaseous liquids go around above his experimental table.

Wei Zhenxue shook his head again and again, and said, "Yang Rui, it's not me who said, you are indeed a genius biologist, the strongest I have ever seen, and Peking University probably can't find anyone better than you." But biology and chemistry are not the same, you are a biologist, and then you are a biological genius, and you are also good at biology, but I am a chemist, and synthetic chemistry should listen to me, right?"

"Do it first and see ......," Yang Rui perfunctorily Wei Zhenxue.

"If you don't listen to me, why are you looking for me? Wei Zhenxue said angrily: "If you don't listen to me, I'll go back." ”

With that, Wei Zhenxue was about to leave.

Yang Rui was stunned and said, "I asked you to be an assistant, and I didn't ask you to be an uncle." ”

"Is that so?" Wei Zhenxue's steps as he left paused.

"Of course. ”

"You don't want me to help you make the synthesis of deferiprone for you?"

"You're helping as an assistant. ”

"That's right...... I thought you asked me to do the work. Wei Zhenxue turned his neck around, returned to the test bench, and said, "Then I'll be an assistant." ”

"It was. Yang Rui couldn't cry or laugh, he hadn't experienced Wei Zhenxue's second for a while, and he was still a little uncomfortable when he first met.

Wei Zhenxue has never changed, he re-read Yang Rui's experimental records, and the more he looked at it, the more he shook his head, and said: "Even if you don't let me preside over the work, when I am an assistant, I have to say that you can't do this!"

"We'll see. "Yang Rui knew that he couldn't do it a few times before, but he also practiced his hands, and was familiar with the instruments and equipment and test methods in this area.

Wei Zhenxue was also overwhelmed by the rolling self-confidence, and swore and said: "I'll wait and see, if you can directly synthesize ferrite with methylamine, I will screw my head off and kick it for you." ”

Yang Rui couldn't help laughing.

Huang Mao, Tu Xian, Li Wenqiang and others in the laboratory also passed by curiously when they heard the bet.

Wei Zhenxue inexplicably felt a chill in the back of his neck.

……