Anyone who came over to lobby Yang Rui, Yang Rui was ready to go back head-on.

If it doesn't work, you can also turn on the mode of "I don't listen, I don't listen, I just don't listen".

However, Yang Rui couldn't even listen to Professor Cai's words.

Cao Baoming and Wang Guohua, who followed him, stayed behind, and the two of them walked around the laboratory, and Yang Rui invited Professor Cai into the office.

Professor Cai did not hide his purpose, sat down, first mentioned the Jingxi Pharmaceutical General Factory, and then talked about the investment of the Jingxi Pharmaceutical General Factory in biological experiments over the years, and then, the conversation changed, that is, he said: "The Jingxi Pharmaceutical General Factory will not be able to survive, they used to produce tablets and powders, and now the factories in the south are opening one after another, and the price is lower than their cost, and their old customers have been robbed." Qin Hanchi's agent Miki's medicine is the last fight to break the cauldron. If it fails, the thousands of workers at the Jingxi Pharmaceutical General Factory, as well as the raw material factory that supplies them, will be in trouble. ”

"Do you know Qin Hanchi?" asked Yang Rui.

"Yes, but this time it was the old Zhangtuo who came to me. Professor Cai then explained: "Lao Zhang is from the GMP Preparatory Committee, and he also supported the by-election before, and several old friends from the Ministry of Health also called. ”

When Yang Rui followed Professor Cai to run projects and achievement appraisals, he had seen Professor Cai's broad network, but on the other hand, a broad network also means that he has to bear the cost of making friends.

Yang Rui nodded silently and continued to listen.

Seeing this, Professor Cai said: "If you have any ideas, just tell me, if you can tell them, I will tell them, and if you can't tell you, let's discuss it together." ”

Then, Professor Cai smiled and said, "Although I am here to help Qin Hanchi speak, I can also help you speak." ”

Yang Rui smiled bitterly: "Why does everyone think I have ulterior motives." ”

"Huh?"

"It's because I don't trust the drug that I asked them to supplement the safety test. Yang Rui said helplessly: "The research report of the legal and public table is very insufficient, and it is very risky to rashly produce and promote it in China. ”

"More risky than proprietary Chinese medicine?"

Yang Rui was speechless. In this discussion, he and Professor Cai are not of the same order of magnitude.

After thinking for a moment, Yang Rui said: "The scale of use of Lybodine is larger than that of Chinese patent medicine, and in addition, Lybodine is designed to be used for long-term use, so if there is a safety problem, its risk will continue to accumulate, I think, a little more rigorous, is not a wrong thing." ”

Professor Cai looked at Yang Rui fixedly for a while, and suddenly said, "This is not like your style." ”

"What's my style?" Yang Rui was dumbfounded.

"Unstoppable. Professor Cai gave his own answer.

Yang Rui recalled that when he was doing potassium ion channels, he did it relatively simply, but the follow-up lawsuit was millions, and he didn't want to settle at all, and he fought hard with indomitable progress, and the subtext of "indomitable" is a huge risk.

Yang Rui was quite embarrassed, thinking about it like this, he did have some problems of "this time and that time".

"When everyone talks about me now, isn't my reputation not very good?" Yang Rui brushed his face a lot, and he could guess how the market viewed him.

When "this time and that time" is linked to power, there is never anything good to say.

Professor Cai said: "The scale of Jingxi Pharmaceutical General Factory is also in the forefront of the country. Qin Hanchi has been a factory director for nearly ten years, and he is not a bad person. ”

Yang Rui sighed and said, "I don't want to be a bad guy either." ”

"Then let the Jingxi Pharmaceutical General Factory pass the customs. ”

"There's a problem with Lybord. Yang Rui stopped talking around and around, and answered directly.

Professor Cai naturally asked a question that Yang Rui didn't want to answer further: "What question?"

Yang Rui couldn't answer.

As an anti-cardiac drug, the foundation of its academic research is actually very solid. Identifying premature beats as a disease, then associating them with more serious heart disease, and then determining that suppressing premature heart beats is beneficial in reducing the risk of heart disease - this whole academic chain, not in a day or two, not in one person or two people. This is an academic research that has been established more than 10 years ago with the participation of hundreds of scholars, and LyBoding is just one of the star products.

Anti-heart rhythm drugs are not even the only drug of Libodine, and in the 8o years, almost all large pharmaceutical companies were involved in it.

And in the past ten years, in the process of developing multiple drugs, has no one questioned the entire academic chain?

Of course.

However, academic discussion is only academic discussion after all, and the most important problem is that there is no fundamental flaw in anti-heart rhythm theory.

Even Yang Rui can't categorically say that the anti-heart rhythm theory is wrong.

The anti-heart theory may not be wrong, with the simplest thinking, the heart does not beat early, it is better than the heart beats early. After all, premature cardiac beats are always an abnormal physiological phenomenon, and it seems like a good thing if it can be treated or suppressed at no cost.

So, the crux of the matter comes back to the safety of the drug itself, or the drug itself.

So, how do you prove the safety of Lybordin?

Yang Rui knows that the problem with anti-cardiac drugs like Libodine lies in their impact on electrical impulses.

But there is no basis for the words, but the Miki company has made a file cabinet to prove its safety and efficacy tests.

For Yang Rui, the best way to prove it is clinical trials, because the side effects of Libodine are hidden, and it takes a long time for them to appear, so the ordinary clinical trials that are not large in scale and for a long time are not enough, and it is necessary to find hundreds or even thousands of patients with arrhythmia to do double-blind tests, half of them take Libodine, and half of them use placebo, which is equivalent to a large-scale clinical phase I.

As far as Yang Rui's experience in doing deferiprone is concerned, to get a more definite answer, it will cost about 4ooo US dollars, and it will take more than half a year, which is about the same - of course, the number of patients with possible heart damage must be some, and there will be a few more deaths.

Can Yang Rui get 4ooo dollars? Of course he can't get it, he hasn't seen much of the milestone payment for ferrite, and besides, he can't do this, he has 4ooo dollars, and he can research a new drug.

And if you don't do clinical trials, you will engage in academic debates, and Yang Rui's current status will not be able to fight others.

There are also big bulls in the research group that do Lu Boding, people have been engaged in this drug for nearly ten years, and they have memorized more information than Yang Rui has seen, even if Yang Rui can talk eloquently, he can't add that others have the strength to pass the FDA.

To be reasonable, the FDA has always been criticized for being too inefficient and too demanding, but there are very few cases where the audit is not rigorous.

There may be some incompleteness in the review of Lybodin, but in terms of the insidious and slow side effects, the FDA has actually done a good enough job.

The FDA may have asked all the questions that Yang Rui could ask verbally.

"The key now is not that I have to prove that there is a problem with Lybordin, but that Jingxi Pharmaceutical General Factory wants to prove to me that Lyboding is fine. Yang Rui's eyebrows drooped for a moment, then quickly raised, and said, "Professor Cai, I'm sorry, I have to save your face, and I have to be responsible for my signature." ”

"Even if Jingxi Pharmaceutical Factory finds more people to put pressure on you, you won't let it go, will you?" asked Professor Cai calmly.

Yang Rui nodded slightly.

"You must know that Qin Hanchi has not only found me, in order to pass the law and Boding, the whole factory of Jingxi Pharmaceutical General Factory is trying to find a way. And ......," Professor Cai lowered his voice and said, "They have a lot of reasons. ”

"I know. ”

"You're not afraid?"

"I'm afraid, I'm scared to death. Yang Rui smiled bitterly, if he wasn't afraid, why would he call Wang Guohua and Cao Baoming over.

Even if he doesn't use violent means, Yang Rui is actually not sure how long he can carry it. As the saying goes, when you arrive in the capital of North A, you will know that the official is small, and the taxi driver in Beijing in North A, who is around and around, can know a department-level cadre, Qin Hanchi himself is a department-level cadre, and what level of cadre can he contact?

The official university crushed people to death, and Yang Rui did not live in a vacuum.

However, Yang Rui asked himself, he may not be able to completely stop Lu Boding, but it would be good if he could delay it for one more day. When he entered China one day later, the number of Chinese people affected by it may be tens of thousands, and perhaps some people will survive because of this, and there will certainly be many people who will be exempted from the risk of heart damage, so that they may live for several more years, or more than ten years.

In addition, the delay in the production of the Jingxi Pharmaceutical General Factory may also reduce the supply of Liboding in the global market, and the supply of pharmaceutical factories will be reduced, and the medical representatives will not work so hard to promote, and the number of patients taking Liboding may also be reduced, and there will be fewer deaths.

Professor Cai looked at Yang Rui's expression, but he inexplicably realized Yang Rui's state of mind, just like the Yang Rui he saw in the Tang Concentration Laboratory back then.

"It's still your style. Professor Cai exhaled.

Yang Rui looked at him.

"Your style. Professor Cai pointed his finger at him and said, "Go forward." ”

……