When everyone finally returned to school, it was already 9:01 a.m. Pen % fun % Pavilion www.biquge.info

"There's no business more lucrative than pharmaceuticals!"

Ashley jumped at the front of the foursome, because she couldn't calm down because of what she encountered today: "Think about the income of the profession, surgeon, dentist, they are all firmly in the top two of the American professional rankings!" ”

"But this industry is not so easy to set foot in, Ashley, you must be calm."

Although she was persuading, Alice was still satisfied to see that the three friends were all happy. Good friends should share happiness with each other, and Alice's industry is also quite a lot, and they basically give them some shares. In other words, if she really sets foot in the pharmaceutical industry and really makes a lot of money, Ashley and others will also be direct beneficiaries.

Therefore, they naturally have a lot of suggestions, as Maiya then said: "It's not easy, in the world, the pharmaceutical industry is a traditional industry." So Alice, how much do you know about the industry? Have you done your research? ”

Alice immediately replied in the affirmative: "Don't worry, I checked it as early as when I asked Delov to start researching the I virus......"

Sissi muttered, "i, virus, what a stupid name." ”

“…… Ahem, but before that, let me give you a brief description of the market in the pharmaceutical industry around the world. ”

This is very important information, and for a while, Sissi stopped complaining, and everyone stared at Alice.

"Five of the world's top 10 pharmaceutical companies are in the United States. At the top of the list is Pfizer, a multinational pharmaceutical company based on research and development with a history of more than 120 years. Headquartered in New York, it has three main business segments: Healthcare, Animal Health, and Consumer Health. When it comes to the most famous products...... Ashley, do you feel familiar? ”

"Viagra! Viagra! Phew~Ha! Alice, why don't we just buy this company! ”

", that's for men, what do you mean?"

"Oh~Sissi~ Even if it's you a man~"

"Don't come here! Don't make that weird noise! Feed!? What are you doing!? Alice, stop her~! ”

Even with her eyes closed, she can conceive a picture in her brain, not to mention that Alice is still watching their farce with her own eyes, laughing and hugging Sissi's shoulders, she flicked her hooves and easily forced back Ashley's aggression with her teeth and claws: "Hehehehe~ I said Wumi, don't you stop it?" ”

Now that she had been named, Maiya stepped forward with ease, grabbed Ashley by the collar with one hand, and dragged her aside like a chicken.

"You bastards are pretty good at interrupting me."

Looking at the sky and holding her forehead for a moment, Alice shook her head: "Continuing with the previous topic, Johnson & Johnson, the second largest company in the world, has a history of exactly 100 years since its establishment, and it is also a comprehensive super enterprise. Of course, the gap between these faucets is always changing, although it has been ranked second in the past two years, but it is okay to rush to the first place after a few years, it is not a fixed thing. ”

"The Franco-German joint venture Sanofi-Aventis Group is the world's third-largest pharmaceutical company and the number one pharmaceutical company in Europe, and it is a leader in seven therapeutic areas: cardiovascular disease, thrombosis, oncology, diabetes, central nervous system, internal medicine and vaccines. At present, its business has expanded to nearly 100 countries, and of course, it is also related to its geographical location."

Furthermore, Geigy in Switzerland is also large and has a very long history. As early as 1758, Mr. Geigy was involved in chemicals, dyes and pharmaceuticals in Basel, Switzerland, and the family business grew to become the world's leading pharmaceutical behemoth in Switzerland. ”

"Hmm...... There is also one in the UK, called GlaxoSmithKline. It represents the highest level in the world today in the four major medical fields of anti-infection, central nervous system, respiratory and gastrointestinal metabolism, and also ranks first in the industry in the field of vaccines. In addition, the company is a leader in the world consumer healthcare market, with products including over-the-counter drugs, oral care products and nutraceuticals. ”

"If there is one more company in the United States that catches my attention the most, it is Wyeth. It is one of the world's largest, research-based pharmaceutical and healthcare products companies, headquartered in New Jersey, USA. It plays a pivotal role in the research, development, manufacturing and operation of prescription and over-the-counter drugs, as well as vaccines, bioengineering, agricultural products and animal health products. ”

After a long speech, seeing that the three friends were already a little stunned, Alice shrugged and said, "So you see, all of them are century-level, global-scale supergiants. If I rashly take the finished drug of the I virus, and casually open a pharmaceutical factory to prepare for sale, every second is the rhythm of being acquired. ”

"Then, we need to take one step at a time."

While walking slowly, Maiya intimately analyzed Alice: "Alice, do you understand the procedures and preparations required to open a pharmaceutical factory?" ”

"The problems of company registration and location selection are the same for all enterprises, and the medical industry needs to pay attention to the FDA."

Very organized, Alice said to her partners: "As the so-called, the U.S. Food and Drug Administration, whether we plan to sell medical devices or drugs we take directly, we have to go through their supervision and management. At this time, if the entrepreneur can get to know the government officials of the relevant departments, they will often save a lot of time and energy. Obviously, our dear Vice President Bush, this is where I can do some help, if I invest a few million in his son's oil company...... Ahem, you get the idea. ”

"The FDA has a complete certification process for pharmaceutical products to ensure that new drugs are safe and effective. The general sequence is that a pharmaceutical company submits an investigational new drug application to the FDA, and then the FDA sends someone to test the new drug. At this time, the human trial of the new drug has not yet begun - unless you have already done secret and illegal experiments - the FDA mainly reviews the in vitro safety data and animal experiment data to determine whether the drug is safe enough to enter the human trial stage. ”

"Human experiments are divided into four stages, the first phase mainly tests the safety, main side effects and metabolic mechanism of the drug, and the number of experimental samples is generally less than 200. The second phase mainly tests the effectiveness of the drug to determine whether the drug can effectively act on the human body; At the same time, the safety and toxicity and side effects of drugs are also closely observed; At this stage, the number of experimental samples is generally less than 300 and more than 200. ”

"If the phase 2 trial is encouraging, a larger sample will be ready for testing, i.e. the experiment will move into phase 3. Phase III will include different age groups, different populations, and different dosages to comprehensively study the safety and efficacy of the drug. The number of samples in the third phase of the experiment ranged from a few hundred to a few thousand. ”

"The last four phases, mainly after the approval of new drugs, mainly test information such as the long-term safety of the drugs. When a pharmaceutical company completes human trials to verify the safety and efficacy of a new drug, it will formally submit the NDA, or new drug application, to the FDA. ”

"At this time, the FDA will review all the animal and human experiment data, as well as the drug substitution mechanism data and GMP data of the production, and if the data is incomplete or unreasonable, it will review it, and under normal circumstances, the whole process will last about ten months, and give an agreement or rejection."

"So ......"

When Alice finished her tirade again and took a sip of the mineral water in her purse, Sissi had a tangled and painful expression on her face, and said in a long voice: "Just from the beginning of the review of the new investigational drug, the whole process will at least ...... For how long? Two years? Or three years? How long is it going!? ”

"It's a medical industry, and it's impossible to be too cautious."

Maiya said smoothly: "So that's why only large companies with abundant funds can set foot in this industry, and the current pharmaceutical factories are all super giants with operations all over the world." Although the FDA was a system that only appeared in the thirties of this century, and these pharmaceutical companies often have a history of hundreds of years, after so many years, you will not believe it if you say that it has not taken deep roots in the political circles, right? ”

"It's complicated, it's complicated, it's complicated!"

Ashley also had a big expression on her face, shouting at the top of her voice, and even made a passing boy who was also returning to bed late at night look sideways, but no one noticed whether he had hit a telephone pole.

"Alice, hurry up and work hard to save money! Anyway, in the short term, Professor Delov will not achieve anything, you hurry up and make more money with Japanese investment. Since it takes several years for the approval of new drugs to be completed, if we can't produce it on a large scale as soon as it comes up, won't it be a loss!? ”

"The order seems a bit problematic, but the basic idea is fine......"

Alice giggled and stood still. At this point, everyone is almost at the door of the dormitory, but the topic of conversation is not something that can be talked about in the dormitory. At this time, standing in the middle school dormitory area in the night, Alice also suppressed her voice.

"My investment in Japan will be hundreds of millions of dollars in cash as soon as I get it, but it will take at least a year or two to bring a return. Professor Delov's research also takes time, and we only have a hint of a new drug or something. So in this blank period......"

She touched her chin, looked at the girls' apartment building in front of her, and said thoughtfully: "Well, none of our classmates have fuel-efficient lamps, people are floating in the rivers and lakes, how can they not have some connections?" (To be continued.) )