Layout: 1 Finding your own breakthrough point is to determine your advantage. No one surpasses it. 2. Effective planning, aiming at a certain field of deep cultivation. 3. Broad knowledge background and certain areas of specialization. 4. Beyond the vision of the times and lofty ideals. 5. High-dimensional thinking, not limiting immediate gains and losses, focusing on the bigger picture. For example, the specific changes of mice can be linked to knowledge in different fields to construct equivalent logic, such as calcium ion channels and so on at the molecular level.6 Down-to-earth learning methods and efforts should break through the barriers to learning. 7. Allocate resources reasonably, such as time, energy, etc., and value yourself. 8. Funds first.

Technology: 1 Cyclic systems need multi-level coupling to form a stable network structure, and the important thing is to have a competitive environment in order to form the structure with the greatest adaptability to the environment. 2. Sufficient resolution is the basis of network research, just as the pathological slides created by the microscope are the non-moving expression of macroscopic diseases. This is the triumph of the instrument, the emphasis on measurement, the basis of quantitative analysis. For example, spectrophotometry is a macroscopic grasp of the properties of matter. 3. Sequence decomposition of complex structures, decomposing the relationship of objects into a certain sequence combination, and selecting a certain meaningful pattern. i.e. multi-parameter, proportional determination.

Thoughts: The 1-fractal structure can construct a larger low-dimensional structure in a limited space, such as the greater the measurement accuracy of the coastline, the longer the path, and the area does not change much. 2 The power of the central law is more evident at the microbial level, and this is a feature that we can exploit. The hierarchical similarity of the 3-fractal structure suggests that the relationship between proteins can also form certain pathways, such as the dependence of enzymes and coenzymes. 4 The determination of the meaning of natural language is the process of the collapse of the wave function, the semantics are constantly shrinking, and the inference of information is the Bayesian method. Cognitive boundaries.

Impressions: 1. Keep up with the trend of development and take the initiative to dig out problems. Strive to try to transform scientific research results. 2. Understand the proximity problem in many ways, which is the multi-level differentiation of the network. 3 The idea of economics is the practice of rational people, to be grasped, which is the basis for understanding the complex world. 4. Have the courage to be a trendsetter and break through the existing model. 5. Pay attention to marginal benefits, and stop loss in time when it drops to a certain extent. 6. Conciseness is not simple, but a clear understanding of the immovable point of the network. 7. The first step in doing research is to conduct literature research and stand on the shoulders of giants. Then a certain combination and screening will be carried out. Finally, a meaningful pattern is formed. 8. Grasp the irreplaceable key points and become the core of multi-level dependence.

Layout: 1 The courage to learn from the experience of our predecessors, this is the basis of our development, and we need to know the existing road to find a new way. 2. The importance of learning English. 3Literature research can narrow the scope of research and help to concentrate resources, so as to find the best model in large-scale screening. 4. Good foundation and a clear sense of direction.

Technique: 1. Using the underlying universality of the central law, which is the basis of genetic engineering, specific properties can be transferred to different species such as microorganisms for production, so as to construct the equivalent path of animal and plant microorganisms. 2. The strict R&D chain is a high-dimensional structure, which establishes a series of key technologies around the core technology, and then uses a series of technologies to surround a series of key technologies. 3 complete experimental records and standardized treatment 4 molecular mechanism research, the macroscopic relationship decomposition, such as sodium and potassium ion channel blockers have a certain effect on arrhythmia, hypertension and other diseases, you can study the role of various ion channel proteins (fixed point) and their synthesis, because we need to concentrate on a limited range but at the same time can not ignore other interactions, so take the method of partial derivation, the probability is equal to the derivative. 4. A stable role requires a certain coupling pair, such as the competitive game of agonists and antagonists. 5 Cloning is a fundamental motivator that allows specificity to emerge, just like PCR and natural selection. 6. Accurate classification can reduce the number of objects for sequential operations, so that the results obtained are more relevant. 6. By comparing the mutation and normal sequences at various levels, the role of low-level variation can be derived. 7. The construction of basic technology, the amplification of specific properties through the limitation of conditions, this is the movement of equilibrium.

Thoughts: 1 The dominant recessive nature of genes and the selective expression of traits are similar to those of Markov sequences. Hybridization is an experimental method that reveals various relationships and thus constructs pathways. 2 The central law provides a theoretical basis for the construction of the equivalence relationship between proteins and genes, and we can partially understand the properties of proteins by studying gene sequences. 3. The premise that the direction is more important than effort is that the direction is known to be the realization of the future, otherwise the probability can only be stacked by the Bayesian formula. 4. For accurate measurements, the single-molecule level and other low-dimensional levels can be traversed to form high-dimensional structures. The interaction of the five levels makes the network only at the module level in a macroscopic mechanical analogy, in fact, the modules of the network have a certain compensatory nature, so we can only observe various effects at the statistical level. 6 Inducing effects due to sequence coupling, like promoters and primers. 7. The ratio of the formation of positive feedback to other feedback mechanisms is the macrostructure of distribution. The sequence representation of the 8-fractal structure and the network is a process of continuous refinement, like reductionism, and then it needs to be traversed by game theory to form the overall structure. That is, we consider the interaction at different levels, the gene level is partial expression regulation, and the protein level is partial interaction.

Reflections: 1. The logic embodied in experiments and experiments is hard currency. 2. The research direction is the direction of progress, the basis of task decomposition, and the specific path is found in the formation of A_B relationships. 3 Modular, complex technology finally becomes a basic step, and this is progress.

Layout: 1. Adequate preparation in the early stage 2. Take care of the interests of all parties. 3. Bundle interested parties.

Technical Chapter: 1. Comparison of the effects of control experiments on sequences. 2. The relationship of multi-level coupling is reflected in the antagonistic synergy at different levels, such as the antagonism of α1 antitrypsin to proteolytic enzymes, and the antagonism of proteolytic enzymes to general proteins, which are sequences of mutual coupling, and finally can form a certain fractal structure. It is possible to project changes to higher dimensions, only in a different scale. 3. Observation requires differences in objects, and if there is no difference, differences are created, such as staining of pathological sections. 4. Differentiation is a certain equilibrium formed by multi-level competitive games, which is dynamically changing, which is the reason for our individual specificity. There are many contradictions to consider, but resources are limited, and a large part of the body is in a state of waste, but it is better for the overall benefit as a reserve, and it can be selectively expressed at any time to the state of the best adaptability to the environment, which is the principle of natural selection. Of course, we can grasp the high-dimensional structure, that is, the similarity of the levels, and then calculate on this basis. That's the immobility point. For example, pulmonary hypertension is the key to cor pulmonale, i.e., the immobility point. It is also the root of the body's health and disease state. 5. Combination of pattern recognition, to construct a database under normal conditions, considering many factors such as cell type, morphological changes, number ratio, permutations and combinations, etc., the human brain at the subconscious level of operation, and then extract a higher dimensional relationship, such as pathological diagnosis. This is a large-scale computation modeled after a neural network. 6 The infinitesimal quantity of calculus, the sum of which is a fractal structure. A collection of cellular levels exerts forces, such as the heart muscle. 7. Pseudolobular formation and our desire to form a certain capsule at the border of malignant tumors may have certain guiding significance, and the transplantation of specific gene expression patterns is helpful for the benign malignant tumors. 8. Preparation of active substances can be used as a kind of immobility.

Thoughts: 1 The underlying operation of the sequence matches the fractal structure of the central law. Various complex activities, such as replication, etc., establish a certain mapping relationship with the function. 2. The primer initiation mechanism, which is like the energy of the destruction of the original closed-loop coupling structure. 3. Starting from the foundation, the local optimal accumulation is close to the overall optimum. 4. Large-scale trial and error can find a specific path of action, just like the path collapse after traversal. Then there is the optimization of algorithms, such as linear independent quantities for orthogonal experiments, empirical Bayesian formulas, dynamic programming for local optimum, and so on. 5 Specificity can be the key to the formation of specific pathways, just as bridges connect different relationships to form high-dimensional structures. The specific sequence of the primer is the basis for amplification. 6. The analogy of the structure of catalyst and enzyme can be understood as the matching operation of sequence, which is a kind of fixed point and is the selective expression of the comprehensive environment. 7. The emergence of automation and detectors is linked. Light as a tool enables maximum large-scale inspection.

Layout: 1. Drug research and development is the touchstone of mechanism research, whether it can affect specific targets with a certain combination of structures. 2. Irreplaceability is the pursuit of the individual, and for the healthy group, it is the hope of the individual replaceability, and the equilibrium reached by this contradiction is the macro structure of different societies. 3 upgrades, a higher-dimensional perspective, from competition to creation, branching out. The formation of positive feedback contributes to its continuous improvement.

Technique: 1 Screening, the collapse of the path, like natural selection. Large-scale trial and error can refer to certain experience to reduce the probability of failure. 2 The influence of the sequence is the controlling factor. Results of selective expression of pharmacokinetic and pharmacodynamic theories based on human networks. We need to decompose the sequence into different modules, such as simple suppression or activation, but need to build multi-level relationships.

Thoughts: 1. The similarity between industrial catalysts and proteases inspires us to think about drugs. 2. Do the right thing at the right time, because the window for multi-level coupling is very short, that is, the time we can exert influence is very short, and we need to grasp it well. The idea of the 3 sequence lies in the consideration of multiple variables, and different metric criteria can be selected to form different paths. The self-coupling of this sequence can give rise to different properties. 4. The macroscopic structure of diseases and other diseases can also be decomposed into certain sequences according to the assumptions of fractal geometry, and the only effect on the sequence is to substitute new sequences. As for the drugs, they are fixed-point sequences. The holism of 5 omics is the discovery of the system and the development direction of the network.

Reflections: 1 Try to try, this is the search for relationships, and it is the basis for the emergence of patterns. 2. The use of reverse thinking. The closed known can be equated to the open-loop unknown, which is an application of the reflexive law of the network, based on operations on high-dimensional structures, such as the coupling of sequences into loops and then cleavage.